Results 51 to 60 of about 607,096 (382)
Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]
, 2008 The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Ahmed +62 more
core +1 more source
The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus
Vaccines, 2022 After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies ...
Jazmín García-Machorro +3 more
doaj +1 more source
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]
, 2006 PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E. +4 more
core +2 more sources
BioDrugs, 2007 Antibodies are an effective line of defense in preventing infectious diseases. Highly potent neutralizing antibodies can intercept a virus before it attaches to its target cell and, thus, inactivate it. This ability is based on the antibodies' specific recognition of epitopes, the sites of the antigen to which antibodies bind.
Gershoni, Jonathan M. +4 more
openaire +2 more sources
VirulenceOrf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA virus that causes significant economic losses in the livestock industry.
Feng Pang, Qinqin Long, Shaobo Liang
doaj +1 more source
CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor
Frontiers in Microbiology, 2016 Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins.
Stephanie eAscough +11 more
doaj +1 more source
Foods, 2022 Milk protein hydrolysates are common in infant formula, but some of them retain allergenicity due to incomplete hydrolysis of the epitopes for milk allergens.
Di Liu +3 more
doaj +1 more source
Neutralizing Antibody Response to Hepatitis C Virus
Viruses, 2011 A critical first step in a “rational vaccine design” approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection. Emerging evidence provides support for a protective role of virus neutralizing antibodies, and the
Zhen-Yong Keck +2 more
doaj +1 more source
Viruses, 2022 Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang +23 more
doaj +1 more source
The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
Frontiers in Immunology, 2017 The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens.
Ward Fleri +6 more
semanticscholar +1 more source