Intact Transition Epitope Mapping—Serological Inspection by Epitope EXtraction (ITEM—SIX) [PDF]
Molecules, 2023 Precision medicine requests accurate serological inspections to precisely stratify patients for targeted treatment. Intact transition epitope mapping analysis proved surrogate seroconversion of a model organism’s serum when spiked with a monoclonal ...
Agatino Zammataro +4 more
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State of the art in epitope mapping and opportunities in COVID-19 [PDF]
Future Science OA, 2023 The understanding of any disease calls for studying specific biological structures called epitopes. One important tool recently drawing attention and proving efficiency in both diagnosis and vaccine development is epitope mapping. Several techniques have
Samira M Hamed +4 more
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Massively-multiplexed epitope mapping techniques for viral antigen discovery [PDF]
Frontiers in Immunology, 2023 Following viral infection, viral antigens bind specifically to receptors on the surface of lymphocytes thereby activating adaptive immunity in the host.
Diya Hu +4 more
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Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM). [PDF]
PLoS ONE, 2014 The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has ...
Xiang Xu +13 more
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Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies [PDF]
mAbs, 2023 Monoclonal antibodies have become an important class of therapeutics in the last 30 years. Because the mechanism of action of therapeutic antibodies is intimately linked to their binding epitopes, identification of the epitope of an antibody to the ...
Xibei Dang +17 more
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Integrating machine learning to advance epitope mapping [PDF]
Frontiers in ImmunologyIdentifying epitopes, or the segments of a protein that bind to antibodies, is critical for the development of a variety of immunotherapeutics and diagnostics. In vaccine design, the intent is to identify the minimal epitope of an antigen that can elicit
Simranjit Grewal +3 more
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The mass spectrometric intact transition epitope mapping method supports protein engineering of foldon trimer variants. [PDF]
Sci RepKoy C +4 more
europepmc +3 more sources
PLoS Computational Biology, 2022 Antibody epitope mapping of viral proteins plays a vital role in understanding immune system mechanisms of protection. In the case of class I viral fusion proteins, recent advances in cryo-electron microscopy and protein stabilization techniques have ...
Marion F S Fischer +2 more
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Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody
mAbs, 2022 Anti-drug antibodies (ADA) can limit the efficacy and safety of therapeutic antibodies. However, determining the exact nature of ADA interactions with the target drug via epitope mapping is challenging due to the polyclonal nature of the IgG response ...
Arthur J. Schick +5 more
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PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides. [PDF]
PLoS ONE, 2012 Epitope mapping from affinity-selected peptides has become popular in epitope prediction, and correspondingly many Web-based tools have been developed in recent years. However, the performance of these tools varies in different circumstances.
Wenhan Chen +3 more
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