Intact Transition Epitope Mapping—Serological Inspection by Epitope EXtraction (ITEM—SIX) [PDF]
Molecules, 2023 Precision medicine requests accurate serological inspections to precisely stratify patients for targeted treatment. Intact transition epitope mapping analysis proved surrogate seroconversion of a model organism’s serum when spiked with a monoclonal ...
Agatino Zammataro +4 more
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Massively-multiplexed epitope mapping techniques for viral antigen discovery [PDF]
Frontiers in Immunology, 2023 Following viral infection, viral antigens bind specifically to receptors on the surface of lymphocytes thereby activating adaptive immunity in the host.
Diya Hu +4 more
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State of the art in epitope mapping and opportunities in COVID-19 [PDF]
Future Science OA, 2023 The understanding of any disease calls for studying specific biological structures called epitopes. One important tool recently drawing attention and proving efficiency in both diagnosis and vaccine development is epitope mapping. Several techniques have
Samira M Hamed +4 more
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Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM). [PDF]
PLoS ONE, 2014 The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has ...
Xiang Xu +13 more
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Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies [PDF]
mAbs, 2023 Monoclonal antibodies have become an important class of therapeutics in the last 30 years. Because the mechanism of action of therapeutic antibodies is intimately linked to their binding epitopes, identification of the epitope of an antibody to the ...
Xibei Dang +17 more
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Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]
, 1992 Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine +49 more
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An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction [PDF]
Journal of Immunology Research, 2016 Identification of B-cell epitopes is a fundamental step for development of epitope-based vaccines, therapeutic antibodies, and diagnostic tools. Epitope-based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in-
Lenka Potocnakova +2 more
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Integrating machine learning to advance epitope mapping [PDF]
Frontiers in ImmunologyIdentifying epitopes, or the segments of a protein that bind to antibodies, is critical for the development of a variety of immunotherapeutics and diagnostics. In vaccine design, the intent is to identify the minimal epitope of an antigen that can elicit
Simranjit Grewal +3 more
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Epitope Mapping and Tagging by Recombination PCR Mutagenesis
BioTechniques, 1997 We describe a rapid PCR method that directly inserts an epitope tag into an open reading frame (ORF) to facilitate protein detection. This project was performed within a varicella-zoster virus (VZV) system.
Christopher Hatfield +3 more
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, 1996 Overview: Choosing a Method for Epitope Mapping Glenn E. Morris Crystallographic Studies of Antigen-Antibody Interactions Frederick A. Saul and Pedro M. Alzari Epitope Mapping Antibody-Antigen Complexes by Nuclear Magnetic Resonance Spectroscopy Irina Kustanovich and Anat Zvi Mapping Epitopes on Antigens by Immunodiffusion in Gel Giuseppe A.
Glenn E. Morris
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