Results 11 to 20 of about 1,474,718 (406)
Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody
mAbs, 2022 Anti-drug antibodies (ADA) can limit the efficacy and safety of therapeutic antibodies. However, determining the exact nature of ADA interactions with the target drug via epitope mapping is challenging due to the polyclonal nature of the IgG response ...
Arthur J. Schick +5 more
doaj +2 more sources
Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. [PDF]
PLoS ONE, 2016 The interferon gamma, enzyme-linked immunospot (IFN-γ ELISpot) assay is widely used to identify viral antigen-specific T cells is frequently employed to quantify T cell responses in HIV vaccine studies.
Andrew Fiore-Gartland +10 more
doaj +2 more sources
Anti-Ro60 Seropositivity Determines Anti-Ro52 Epitope Mapping in Patients With Systemic Sclerosis
Frontiers in Immunology, 2018 Epitope mapping of anti-Ro52 antibodies (Abs) has been extensively studied in patients with Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE).
Athanasios Gkoutzourelas +10 more
doaj +2 more sources
MAbTope: A Method for Improved Epitope Mapping [PDF]
The Journal of Immunology, 2018 Abstract Abs are very efficient drugs, ∼70 of them are already approved for medical use, over 500 are in clinical development, and many more are in preclinical development. One important step in the characterization and protection of a therapeutic Ab is the determination of its cognate epitope.
Eric Reiter +15 more
openaire +7 more sources
Dengue virus antibody database: Systematically linking serotype-specificity with epitope mapping in dengue virus. [PDF]
PLoS Neglected Tropical Diseases, 2017 BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central ...
Sidhartha Chaudhury +5 more
doaj +2 more sources
Hydrogen deuterium exchange and other mass spectrometry- based approaches for epitope mapping
Frontiers in Analytical Science, 2023 Antigen-antibody interactions are a fundamental subset of protein-protein interactions responsible for the “survival of the fittest.” Determining the interacting interface of the antigen, called an epitope, and that on the antibody, called a paratope, is
Prashant N. Jethva, Michael L. Gross
semanticscholar +1 more source
Science immunology, 2021 CD8+ T cell recognition is detected throughout the SARS-CoV-2 genome and is associated with COVID-19 disease severity. T cells are important for effective viral clearance, elimination of virus-infected cells and long-term disease protection.
S. Saini +7 more
semanticscholar +1 more source
PLoS Computational Biology, 2022 Antibody epitope mapping of viral proteins plays a vital role in understanding immune system mechanisms of protection. In the case of class I viral fusion proteins, recent advances in cryo-electron microscopy and protein stabilization techniques have ...
Marion F S Fischer +2 more
doaj +1 more source
Communications Biology, 2021 As Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to spread, characterization of its antibody epitopes, emerging strains, related coronaviruses, and even the human proteome in naturally infected patients can guide the development ...
W. Haynes +85 more
semanticscholar +1 more source
PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides. [PDF]
PLoS ONE, 2012 Epitope mapping from affinity-selected peptides has become popular in epitope prediction, and correspondingly many Web-based tools have been developed in recent years. However, the performance of these tools varies in different circumstances.
Wenhan Chen +3 more
doaj +1 more source