High-Throughput B Cell Epitope Determination by Next-Generation Sequencing
Frontiers in Immunology, 2022 Development of novel technologies for the discovery of human monoclonal antibodies has proven invaluable in the fight against infectious diseases. Among the diverse antibody repertoires elicited by infection or vaccination, often only rare antibodies ...
Lauren M. Walker +27 more
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Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. [PDF]
PLoS ONE, 2016 The interferon gamma, enzyme-linked immunospot (IFN-γ ELISpot) assay is widely used to identify viral antigen-specific T cells is frequently employed to quantify T cell responses in HIV vaccine studies.
Andrew Fiore-Gartland +10 more
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Data on the epitope mapping of soybean A2 and A3 glycinin
Data in Brief, 2016 The data information provided in this article relate to our research article “Using patient serum to epitope map soybean glycinins reveals common epitopes shared with many legumes and tree nuts” (Saeed et al., 2016) [1].
Hanaa Saeed +3 more
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BioDrugs, 2007 Antibodies are an effective line of defense in preventing infectious diseases. Highly potent neutralizing antibodies can intercept a virus before it attaches to its target cell and, thus, inactivate it. This ability is based on the antibodies' specific recognition of epitopes, the sites of the antigen to which antibodies bind.
Gershoni, Jonathan M. +4 more
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Computational epitope map of SARS-CoV-2 spike protein.
PLoS Computational Biology, 2021 The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein. S is exposed on the viral surface and mediates viral entry into the host cell.
Mateusz Sikora +5 more
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Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM). [PDF]
PLoS ONE, 2014 The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has ...
Xiang Xu +13 more
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Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions
Microbiology Spectrum, 2023 The SARS-CoV-2 nucleocapsid (N) protein is highly immunogenic, and anti-N antibodies are commonly used as markers for prior infection. While several studies have examined or predicted the antigenic regions of N, these have lacked consensus and structural
Jacob P. Vandervaart +10 more
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Acta Chimica Slovenica, 2016 Detailed knowledge of antigenic determinants is crucial when characterizing therapeutic and diagnostic antibodies, assessing vaccine effectiveness and developing epitope-based vaccines. Most epitope mapping approaches are labor intensive and costly.
Tomaž Bratkovič, Peter Molek
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Anti-Ro60 Seropositivity Determines Anti-Ro52 Epitope Mapping in Patients With Systemic Sclerosis
Frontiers in Immunology, 2018 Epitope mapping of anti-Ro52 antibodies (Abs) has been extensively studied in patients with Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE).
Athanasios Gkoutzourelas +10 more
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Comparative characteristic of the methods of protein antigens epitope mapping [PDF]
The Ukrainian Biochemical Journal, 2014 Comparative analysis of experimental methods of epitope mapping of protein antigens has been carried out. The vast majority of known techniques are involved in immunochemical study of the interaction of protein molecules or peptides with antibodies of ...
O. Yu. Galkin
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