Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]
, 2008 The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Ahmed +62 more
core +1 more source
High-resolution epitope mapping of anti-Hu and anti-Yo autoimmunity by programmable phage display
Brain Communications, 2020 Paraneoplastic neurological disorders are immune-mediated diseases understood to manifest as part of a misdirected anti-tumor immune response. Paraneoplastic neurological disorder-associated autoantibodies can assist with diagnosis and enhance our ...
B. O’Donovan +12 more
semanticscholar +1 more source
SARS-CoV-2 Epitope Mapping on Microarrays Highlights Strong Immune-Response to N Protein Region
bioRxiv, 2020 A workflow for SARS-CoV-2 epitope discovery on peptide microarrays is herein reported. The process started with a proteome-wide screening of immunoreactivity based on the use of a high-density microarray followed by a refinement and validation phase on a
Angelo Musicò +11 more
semanticscholar +1 more source
Computational epitope map of SARS-CoV-2 spike protein.
PLoS Computational Biology, 2021 The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein. S is exposed on the viral surface and mediates viral entry into the host cell.
Mateusz Sikora +5 more
doaj +1 more source
Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions
Microbiology Spectrum, 2023 The SARS-CoV-2 nucleocapsid (N) protein is highly immunogenic, and anti-N antibodies are commonly used as markers for prior infection. While several studies have examined or predicted the antigenic regions of N, these have lacked consensus and structural
Jacob P. Vandervaart +10 more
doaj +1 more source
Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data [PDF]
, 2018 Hepatitis C virus (HCV) is a global health issue. Although direct-acting antivirals are available to target HCV, there is currently no vaccine. The diversity of the virus is a major obstacle to HCV vaccine development. One approach toward a vaccine is to
Cowton, Vanessa M. +3 more
core +2 more sources
Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping
Journal of Immunological Research, 2020 This new decade has started with a global pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), precipitating a worldwide health crisis and economic downturn.
Yan Lu +11 more
semanticscholar +1 more source
Mapping Immunodominant Antibody Epitopes of Abrin [PDF]
Antibodies, 2020 Abrin, a toxin isolated from the seeds of Abrus precatorius (jequirity pea) is considered a biological threat agent by the Center for Disease Control and Prevention. To date, there is no effective postexposure treatment for abrin poisoning, and efforts are being made to develop an efficient vaccine and measures for postexposure therapy. Epitope mapping
Ron Alcalay +6 more
openaire +3 more sources
Antibody Binding Epitope Mapping (AbMap) of Hundred Antibodies in a Single Run
Molecular & Cellular Proteomics, 2020 Antibodies play essential roles in both diagnostics and therapeutics. Epitope mapping is essential to understand how an antibody works and to protect intellectual property.
H. Qi +15 more
semanticscholar +1 more source
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]
, 2013 The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I. +23 more
core +5 more sources