Results 111 to 120 of about 50,861 (164)

Proteome-wide curation of experimentally validated HPV T-cell epitopes identifies key gaps in our understanding of cellular immunity to HPV and informs vaccine design. [PDF]

Front Immunol
Putra SP, Cankat S, Swadling L.
europepmc   +1 more source

CYTOTOXIC T-LYMPHOCYTE RECOGNITION OF HIV - EPITOPE SELECTION AND ESCAPE

, 2016
Mcmichael, A, Rowlandjones, S, Phillips, R   +2 more
openaire   +1 more source

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The specificity of recognition of a cytotoxic T lymphocyte epitope

European Journal of Immunology, 1992
AbstractAn Epstein‐Barr virus (EBV)‐specific CD8+ cytotoxic T lymphocyte (CTL) clone (LC13) was shown to recognize the minimal peptide determinant FLRGRAYGL from the EBNA 3 antigen of the BL74 strain of EBV. The equivalent epitope from the B95‐8 strain (FLRGRAYGI) is not recognized when endogenously presented and the peptide is 15‐fold less active than
S R, Burrows, S J, Rodda, A, Suhrbier, H M, Geysen, D J, Moss   +4 more
openaire   +2 more sources

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

Nature, 1988
Adjuvant arthritis (AA) is a chronic disease inducible in rats by immunization with an antigen of Mycobacterium tuberculosis. After the isolation of arthritogenic T-cell lines and clones, it became possible to demonstrate that the critical M. tuberculosis antigen contained an epitope cross-reactive with a self-antigen in joint cartilage.
W, van Eden, J E, Thole, R, van der Zee, A, Noordzij, J D, van Embden, E J, Hensen, I R, Cohen   +6 more
openaire   +4 more sources

T Lymphocyte Epitope Mapping of Porcine Circovirus Type 2

Viral Immunology, 2007
Immunoreactive T lymphocyte epitopes within the ORF1, ORF2, and ORF 3 products of porcine circovirus type 2 (PCV2) were mapped. For this, overlapping linear 20-mer peptides were synthesized and tested for their ability to induce T lymphocyte proliferation in porcine peripheral blood mononuclear cells (PBMCs) isolated from experimentally PCV2-infected ...
Stevenson, L.S., Gilpin, Deirdre, Douglas, A., Mcneilly, F., Mcnair, I., Adair, B.M., Allan, Gordon   +6 more
openaire   +3 more sources

Identification of Epitopes for CTCL-Specific Cytotoxic T Lymphocytes

1998
Cytotoxic T lymphocytes (CTL) are major effector cells in anti-tumour immunity. Consequently, a number of different strategies are being developed that attempt to utilize these cells in cancer immunotherapy. Among these approaches are vaccination strategies with tumour cells, genetically altered tumours cells, and synthetic peptide analogues of tumour ...
T, Linnemann, C, Brock, K, Sparbier, M, Muche, A, Mielke, A, Lukowsky, W, Sterry, K, Kaltoft, K H, Wiesmüller, P, Walden   +9 more
openaire   +2 more sources

Epitopes recognized by human t lymphocytes on malaria circumsporozoite protein

European Journal of Immunology, 1988
AbstractThe circumsporozoite protein of the malaria parasite Plasmodium falciparum contains regions of nonrepetitive sequences which are predicted to be T cell recognition sites. We synthesized peptides corresponding to three of these regions, and tested their ability to stimulate proliferation of peripheral blood lymphocytes from donors living in a ...
F, Sinigaglia, M, Guttinger, D, Gillessen, D M, Doran, B, Takacs, H, Matile, A, Trzeciak, J R, Pink   +7 more
openaire   +2 more sources

Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization

Vaccine, 1999
Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprotein (NP) of influenza virus.
A, Iwasaki, C S, Dela Cruz, A R, Young, B H, Barber   +3 more
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A specific cytotoxic T‐lymphocyte epitope presentation system for antitumor immunity

International Journal of Cancer, 2009
AbstractThe magnitude of CTL‐mediated immunity response is highly dependent on the density of antigenic peptide–MHC I complexes at the cell surface. In this study, we adopt a novel strategy to promote the surface level of specific peptide–MHC I complexes.
Ying, Wu, Changzhen, Liu, Meiyi, Sun, Hexiao, Shen, Deyin, Guo, Bin, Gao   +5 more
openaire   +2 more sources