Results 121 to 130 of about 50,861 (164)

Identification of murine cytotoxic T-lymphocyte epitopes of bovine herpesvirus 1

Vaccine, 1999
Major histocompatibility complex (MHC) class I molecules present endogenously derived viral peptides to CD8+ cytotoxic T-lymphocytes (CTLs). The objective of this study was to identify the H-2Dd- and H-2Kd-restricted CTL epitopes of bovine herpesvirus 1 (BHV-1), based on the allele-specific peptide motifs (ASPMs) of the above class I molecules.
D S, Zatechka, N R, Hegde, K, Hariharan, S, Srikumaran   +3 more
openaire   +2 more sources

T-lymphocyte epitope identification and their use in vaccine development for HIV-1

Frontiers in Bioscience, 2002
Cellular immune responses mediated by CD8+ cytotoxic T-lymphocytes (CTL) and CD4+ helper T-lymphocytes (HTL) are needed to effectively control and clear many viral pathogens, including HIV-1. Thus, vaccines for HIV-1 capable of inducing CTL and HTL responses are now the focus of multiple academic and industry-based research and development programs ...
Mark J, Newman, Brian, Livingston, Denise M, McKinney, Robert W, Chesnut, Alessandro, Sette   +4 more
openaire   +2 more sources

A method for the rapid identification of T lymphocyte epitopes.

Peptide research, 1992
Mounting interest in host immunity and understanding the pathogenesis of disease has focused attention on the identification of T lymphocyte epitopes within various antigens. This effort has proven troublesome because of time and financial constraints.
T P, Leary, G A, Splitter
openaire   +1 more source

Expression of MHC class II epitopes on human T lymphocyte clones

Cellular Immunology, 1990
Twenty-four CD4+ alloreactive helper T cell clones and eight CD8+ cytotoxic T cell clones from five different donors, all of which were dependent on alloantigen and IL 2 for continued growth, were analyzed by FACS for cell surface expression of HLA-DR, -DQ, and -DP epitopes using monoclonal antibodies against monomorphic and polymorphic determinants ...
G, Pawelec, H J, Bühring
openaire   +2 more sources

Mapping the cytotoxic T-lymphocyte epitopes of Pichinde virus.

2009
One of the aims of this study was to determine whether the glycoproteins of Pichinde virus harbour any cytotoxic T-lymphocyte (CTL) epitopes on the murine haplotypes, H-2$\sp{\rm b}$ and H-2$\sp{\rm d}$ since, on neither of these MHC backgrounds are there any CTL epitopes on the nucleoprotein of this virus.
openaire   +2 more sources

Epitopes on HLA-DQw3 Molecules Recognized by T-Lymphocyte Clones

1989
The DQ region encodes HLA molecules where three different allo-specificities, DQw1, DQw2, and DQw3, may be recognized by antisera. The DQw3 antigen, found on DR4, −5, −7, −w8, and −w9 haplotypes, can be divided into DQw7 and DQw8 and w9 by restriction fragment length polymorphism (RFLP) analysis and certain monoclonal antibodies (MAb) (1).
Knut E. A. Lundin, Gustav Gaudernack, Gunnar Paulsen, Ludvig M. Sollid, Erik Thorsby   +4 more
openaire   +1 more source

Population coverage by HLA class-I restricted cytotoxic T-lymphocyte epitopes

Immunogenetics, 2001
Vaccination using cytotoxic T-lymphocyte (CTL) epitopes has become a widely used immunization strategy, especially because their structure makes them an attractive alternative to the delivery of whole proteins as immunogens. Nonetheless, their use is limited, in particular because of their specificity, being recognized only by cognate HLA alleles.
J, Longmate, J, York, C, La Rosa, R, Krishnan, M, Zhang, D, Senitzer, D J, Diamond   +6 more
openaire   +2 more sources

Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells.

Cancer research, 2002
Tumor cells undergoing programmed death are an attractive source of tumor-associated antigens, and evidences are available for their therapeutic efficacy in vivo when used either alone or in association with dendritic cells. However, little is known about the specificity of the immune response induced by such antigen formulation.
CASTIGLIONI P, MARTIN FONTHECA A, MILAN G, TOMAJER V, MAGNI F, MICHAELSSON J, RUGARLI C, ROSATO, ANTONIO, BELLONE M.   +8 more
openaire   +3 more sources

Epitope recognition of conserved HIV envelope sequences by human cytotoxic T lymphocytes

The Journal of Immunology, 1991
Abstract CTL constitute an essential part of the immune response against the HIV. CTL recognize peptides derived from viral proteins together with the MHC class I molecules on the surface of infected cells. The CTL response could be important in prevention or control of infection with HIV by destroying virus-producing cells.
G, Dadaglio, A, Leroux, P, Langlade-Demoyen, E M, Bahraoui, F, Traincard, R, Fisher, F, Plata   +6 more
openaire   +2 more sources

Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection

2017
Coccidioidomycosis is a potentially life-threatening mycosis endemic to the Southwestern USA and some arid regions of Central and South America. A vaccine against Coccidioides infection would benefit over 30-million people who reside in or visit the endemic regions. Vaccine candidates against systemic fungal infections come in many forms.
Brady J, Hurtgen, Chiung-Yu, Hung
openaire   +2 more sources