Results 261 to 270 of about 77,463 (281)

T Lymphocyte Epitope Mapping of Porcine Circovirus Type 2

Viral Immunology, 2007
Immunoreactive T lymphocyte epitopes within the ORF1, ORF2, and ORF 3 products of porcine circovirus type 2 (PCV2) were mapped. For this, overlapping linear 20-mer peptides were synthesized and tested for their ability to induce T lymphocyte proliferation in porcine peripheral blood mononuclear cells (PBMCs) isolated from experimentally PCV2-infected ...
Stevenson, L.S., Gilpin, Deirdre, Douglas, A., Mcneilly, F., Mcnair, I., Adair, B.M., Allan, Gordon   +6 more
openaire   +4 more sources

A specific cytotoxic T‐lymphocyte epitope presentation system for antitumor immunity [PDF]

International Journal of Cancer, 2009
AbstractThe magnitude of CTL‐mediated immunity response is highly dependent on the density of antigenic peptide–MHC I complexes at the cell surface. In this study, we adopt a novel strategy to promote the surface level of specific peptide–MHC I complexes.
Ying Wu, Ying Wu, Hexiao Shen, Deyin Guo, Bin Gao, Meiyi Sun, Changzhen Liu   +6 more
openaire   +2 more sources

Identification of Epitopes for CTCL-Specific Cytotoxic T Lymphocytes

1998
Cytotoxic T lymphocytes (CTL) are major effector cells in anti-tumour immunity. Consequently, a number of different strategies are being developed that attempt to utilize these cells in cancer immunotherapy. Among these approaches are vaccination strategies with tumour cells, genetically altered tumours cells, and synthetic peptide analogues of tumour ...
Karl-Heinz Wiesmüller, Arlett Mielke, Wolfram Sterry, Carsten Brock, Peter Walden, Thomas Linnemann, Ansgar Lukowsky, Kelt Kaltoft, Marcus Muche, Katrin Sparbier   +9 more
openaire   +3 more sources

Epitopes recognized by human t lymphocytes on malaria circumsporozoite protein

European Journal of Immunology, 1988
AbstractThe circumsporozoite protein of the malaria parasite Plasmodium falciparum contains regions of nonrepetitive sequences which are predicted to be T cell recognition sites. We synthesized peptides corresponding to three of these regions, and tested their ability to stimulate proliferation of peripheral blood lymphocytes from donors living in a ...
Bela Takacs, Daniel M. Doran, Dieter Gillessen, Hugues Matile, J. Richard L. Pink, Francesco Sinigaglia, Maria Guttinger, Arnold Trzeciak   +7 more
openaire   +3 more sources

T-lymphocyte epitope identification and their use in vaccine development for HIV-1

Frontiers in Bioscience, 2002
Cellular immune responses mediated by CD8+ cytotoxic T-lymphocytes (CTL) and CD4+ helper T-lymphocytes (HTL) are needed to effectively control and clear many viral pathogens, including HIV-1. Thus, vaccines for HIV-1 capable of inducing CTL and HTL responses are now the focus of multiple academic and industry-based research and development programs ...
Mark J, Newman, Brian, Livingston, Denise M, McKinney, Robert W, Chesnut, Alessandro, Sette   +4 more
openaire   +2 more sources

Identification of cytotoxic T lymphocyte epitopes in dengue virus serotype 1

Journal of Medical Virology, 2015
Dengue virus (DENV) has a serious and growing impact on global health and the exact role of DENV-specific CD8(+) T-cells in DENV infection is still uncertain. In the present study, SYFPEITHI algorithm was used to screen the amino acid sequence of Dengue virus serotype 1 (DENV-1) for potential epitopes, and seven putative HLA-A*1101-restricted and five ...
Xi Huang, Xi Huang, Huifang Liu, Zhiliang Duan, Xinyu Chen, Jinsheng Wen, Minghua Jiang, Jiang-Long Guo   +7 more
openaire   +3 more sources

Hereditary abnormalities of the OKT4 human lymphocyte epitope in two families

Journal of Clinical Immunology, 1984
The lymphocytes of two unrelated black individuals exhibited no immunofluorescent staining by a monoclonal antibody, OKT4, that reacts with T helper/inducer cells, but the lymphocytes reacted normally with four other monoclonal antibodies that identify T helper cells. Four first-degree relatives of these individuals were available for study. They had a
Donald M. Marcus, Robin A. Karol, David Dennison, Jerald Eng, Elizabeth Faris   +4 more
openaire   +3 more sources

Epitopes of the T19 lymphocyte surface antigen are extensively conserved in ruminants

Veterinary Immunology and Immunopathology, 1991
The reactivity of five monoclonal antibodies (mAbs SBU-T19, 197, IL-A29, CC-15 and CC-39) specific for the T19 molecule on sheep and cattle CD4-CD8- T cells was compared. MAbs SBU-T19 and 197 were shown to recognise separate epitopes on T19. All mAbs reacted with lymphocytes from several different ruminant species and the tissue distribution and ...
Marie Francoise Beya, Wayne R. Hein, Charles R. Mackay, Lisbeth Dudler   +3 more
openaire   +3 more sources

Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization

Vaccine, 1999
Plasmid DNA vaccines encoding full-length antigen often induce both potent antibody and cytotoxic T lymphocyte (CTL) responses. Here, we examine strategies to exclusively elicit epitope-specific CTL responses using DNA constructs expressing a minimal class I MHC-restricted epitope of the nucleoprotein (NP) of influenza virus.
Brian H. Barber, A. Iwasaki, A. R. Young, C. S. Dela Cruz   +3 more
openaire   +3 more sources

Identification of murine cytotoxic T-lymphocyte epitopes of bovine herpesvirus 1

Vaccine, 1999
Major histocompatibility complex (MHC) class I molecules present endogenously derived viral peptides to CD8+ cytotoxic T-lymphocytes (CTLs). The objective of this study was to identify the H-2Dd- and H-2Kd-restricted CTL epitopes of bovine herpesvirus 1 (BHV-1), based on the allele-specific peptide motifs (ASPMs) of the above class I molecules.
Douglas S. Zatechka, S. Srikumaran, Kandasamy Hariharan, Nagendra R. Hegde   +3 more
openaire   +3 more sources