Results 81 to 90 of about 395,501 (352)

A nonstructural polypeptide encoded by immediate-early transcription unit 1 of murine cytomegalovirus is recognized by cytolytic T lymphocytes [PDF]

, 1987
We have constructed target cells by cotransfection of the MHC gene Ld and fragments of murine cytomegalovirus (MCMV) DNA coding for nonstructural immediate-early (IE) proteins.
Keil, Günther M., Koszinowski, Ulrich H., Reddehase, Matthias J., Schickedanz, Jörg, Schwarz, Heinz   +4 more
core   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii [PDF]

, 2016
We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice.
Alexander, Jeff, Bi, Stephanie, Broderick, Kate E., Cardona, Nestor, Chentoufi, Aziz A., Dubey, Jitenter P., El Bissati, Kamal, Fox, Chris, Frazeck, Laura, Guderian, Jeffrey A., Krishack, Paulette A., Lykins, Joseph, McLeod, Rima, Mui, Ernest, Reardon, Catherine A., Reed, Steven, Roberts, Craig W., Sa, Qila, Sette, Alessandro, Sidney, John, Suzuki, Yasuhiro, Vang, Lo, Vedvick, Tom, Verma, Shiv K., Woods, Stuart, Zhou, Ying   +25 more
core   +1 more source

Lack of leu‐3a epitope on t‐helper (cd4) lymphocytes

Journal of Clinical Laboratory Analysis, 1990
AbstractHuman T‐helper cells express membrane‐bound CD4 antigen whose many epitopes are recognized by different monoclonal antibodies. The epitope recognized by Leu‐3a and similar clones has been shown to be the location for human immunodeficiency virus (HIV) receptor.
openaire   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Computational multi-epitope based design of a multivalent subunit vaccine against co-infecting African swine fever virus and porcine circovirus type 2

Veterinary Integrative Sciences
African swine fever virus (ASFV) and porcine circovirus type 2 (PCV2) are two prevalent and economically significant viruses causing high rates of pig mortality and large-scale losses to global pork production.
Lauren Emily Fajardo, Edward C. Banico, Ella Mae Joy S. Sira, Nyzar Mabeth O. Odchimar, Fredmoore L. Orosco   +4 more
doaj   +1 more source

Learning from HIV-1 to predict the immunogenicity of T cell epitopes in SARS-CoV-2

iScience, 2021
Summary: We describe a physics-based learning model for predicting the immunogenicity of cytotoxic T lymphocyte (CTL) epitopes derived from diverse pathogens including SARS-CoV-2. The model was trained and optimized on the relative immunodominance of CTL
Ang Gao, Zhilin Chen, Assaf Amitai, Julia Doelger, Vamsee Mallajosyula, Emily Sundquist, Florencia Pereyra Segal, Mary Carrington, Mark M. Davis, Hendrik Streeck, Arup K. Chakraborty, Boris Julg   +11 more
doaj  

Prediction and identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from endocan

Journal of Inflammation, 2020
Background Prediction and identification of cytotoxic T lymphocyte (CTL) epitopes from tumor associated antigens is a crucial step for the development of tumor immunotherapy strategy. Endocan has been identified as antigen overexpressed in various tumors.
Gaohai Shao, Qingjun Liu, Ling Yang, Guibo Feng, Wang Zhao, Zhongyan Huang, Zhao Yang   +6 more
doaj   +1 more source

Epitope identification and designing a potent multi-epitope vaccine construct against SARS-CoV-2 including the emerging variants

Journal of Global Infectious Diseases, 2022
Introduction: The emergence of a novel coronavirus in China has turned into a SARS-CoV-2 pandemic with high fatality. As vaccines are developed through various strategies, their immunogenic potential may drastically vary and thus pose several challenges ...
Sivasubramanian Srinivasan, Gracy Fathima Selvaraj, Vidya Gopalan, Padmapriya Padmanabhan, Kiruba Ramesh, Karthikeyan Govindan, Aswathi Chandran, Prabu Dhandapani, Kaveri Krishnasamy, Satish Srinivas Kitambi   +9 more
doaj   +1 more source

Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]

, 1992
The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Flieger, Dimitri, Kaluzab, Brigitte, Lenz, Helmut, Reiter, Christian, Rieber, Ernst Peter, Riethmüller, Gert, Scheuer, Werner, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +10 more
core   +1 more source