Results 101 to 110 of about 384,025 (227)

Epitope-based therapeutic targets in HCV genotype 1 non-structural proteins: a novel strategy to combat emerging drug resistance

Frontiers in Cellular and Infection Microbiology
IntroductionThe hepatitis C virus (HCV) poses a major global health challenge, with its non-structural proteins being essential for viral replication and pathogenesis. Mutations in these proteins significantly contribute to drug resistance, necessitating
Mireayi Tudi, Adili Sawuti, Maimaitituerhong Abudurusuli, Chao Wu, Xiaoyu Chen, Gulimire Ailimu, Kuerbannisa Wulayin, Maimaitiaili Tuerxun   +7 more
doaj   +1 more source

Capturing virus evolution by proteomic bioinformatics: Hunting for characteristic mutations in the hepatitis E virus genome

Virulence, 2018
Dominik Harms, Bo Wang, C. Patrick Papp, C.-Thomas Bock   +3 more
doaj   +1 more source

A conserved motif in the immune-subdominant RAP-1 related antigen of Babesia bovis contains a B-cell epitope recognized by antibodies from protected cattle

Frontiers in Immunology
IntroductionBabesia bovis, a tick-borne apicomplexan parasite causing bovine babesiosis, remains a significant threat worldwide, and improved and practical vaccines are needed. Previous studies defined the members of the rhoptry associated protein-1 (RAP-
Manuel J. Rojas, Manuel J. Rojas, Reginaldo G. Bastos, Reginaldo G. Bastos, Jinna Navas, Jacob M. Laughery, Paul A. Lacy, Carlos E. Suarez, Carlos E. Suarez   +8 more
doaj   +1 more source

Identification and Validation of Th1-Selective Epitopes Derived from Proteins Overexpressed in Breast Cancer Stem Cells

Vaccines
Background: Breast cancer stem cells (CSCs), particularly those enriched in triple-negative breast cancer (TNBC), are key contributors to tumor recurrence, metastasis, and resistance to therapy. CSCs often undergo epithelial-to-mesenchymal transformation
Denise L. Cecil, Daniel Herendeen, Meredith Slota, Megan M. O’Meara, Yushe Dang, Lauren Corulli, Mary L. Disis   +6 more
doaj   +1 more source

High Affinity Recognition of a Selected Amino Acid Epitope within a Protein by Cucurbit[8]uril Complexation

, 2016
Silvia Sonzini, Alessio Marcozzi, Raphael J. Gübeli, Christopher F. van der Walle, Peter Ravn, Andreas Herrmann, Oren A. Scherman   +6 more
openalex   +2 more sources

Development of an epitope panel for consistent identification of antigen‐specific T‐cells in humans [PDF]

, 2017
Andreas Fløe, Caroline Løppke, Ole Hilberg, Christian Wejse, Liselotte Brix, Kivin Jacobsen   +5 more
openalex   +1 more source

Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection [PDF]

, 2021
Yang Liu, Dan San, Lei Yin
openalex   +1 more source

Editorial: Epitope Discovery and Synthetic Vaccine Design

Frontiers in Immunology, 2018
Clarisa Beatriz Palatnik-de-Sousa, Clarisa Beatriz Palatnik-de-Sousa, Irene da Silva Soares, Daniela Santoro Rosa, Daniela Santoro Rosa   +4 more
doaj   +1 more source

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

, 2017
Diogo M. Magnani, Cássia Gisele Terrassani Silveira, Brandon C. Rosen, Michael J. Ricciardi, Núria Pedreño-López, Martin J. Gutman, Varian K. Bailey, Helen S. Maxwell, Aline Domingues, Lucas Gonzalez-Nieto, Vivian Iida Avelino‐Silva, Mateus C. Trindade, Juliana Silva Nogueira, Consuelo Silva de Oliveira, Alvino Maestri, Alvina Clara Félix, José Eduardo Levi, Maurício Lacerda Nogueira, Maurício A. Martins, José M. Martinez-Navío, Sebastian Fuchs, Stephen S. Whitehead, Dennis R. Burton, Ronald C. Desrosiers, Esper G. Kallás, David I. Watkins   +25 more
openalex   +2 more sources

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science
Immunotherapy targeting tumor antigens and immune checkpoint inhibitors has garnered significant attention in cancer treatment. Synthetic gene circuits are developed, encoded in plasmids, which regulate the expression of tumor antigens shared with ...
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
doaj   +1 more source