Results 131 to 140 of about 491,390 (408)

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

Antibody recognition of carbohydrate epitopes†.

Glycobiology, 2015
Carbohydrate antigens are valuable as components of vaccines for bacterial infectious agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics against cancer.
O. Haji-Ghassemi, R. Blackler, N. Martin Young, S. V. Evans   +3 more
semanticscholar   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Recent advances and challenges in antigen engineering & vaccine development [PDF]

, 2014
textVaccines play a vital role in public health by preventing infectious disease across the globe. Vaccine formulations represent a weakened form of a microbe or toxin that is injected into the human body to elicit an immune response, generating ...
Kornahrens, William Joseph
core  

Molecular characterization and prediction of B-cell epitopes for the development of SARS-CoV-2 vaccine through bioinformatics approach [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: The SARS-CoV-2 virus is the cause of the COVID-19 pandemic, which is a severe public health crisis worldwide.Aims: To analyze the SARS-CoV-2 isolates of Surabaya and predict ORF1ab polyprotein epitopes through the bioinformatics approach for ...
Aamir Shehzad, Martia Rani Tacharina, Suryo Kuncorojakti, Hafiz Ishfaq Ahmad, Rofiqul A’la, Andi Yasmin Wijaya, Wiwiek Tyasningsih, Fedik Abdul Rantam   +7 more
doaj  

Dissecting Antibodies with Regards to Linear and Conformational Epitopes

PLoS ONE, 2015
An important issue for the performance and specificity of an antibody is the nature of the binding to its protein target, including if the recognition involves linear or conformational epitopes.
Björn Forsström, Barbara Bisławska Axnäs, Johan Rockberg, H. Danielsson, A. Bohlin, M. Uhlén   +5 more
semanticscholar   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

Proceedings of the National Academy of Sciences of the United States of America, 1984
A procedure is described for rapid concurrent synthesis on solid supports of hundreds of peptides, of sufficient purity to react in an enzyme-linked immunosorbent assay.
H. Geysen, Rob H. MELOENt, Simon J. BARTELINGt   +2 more
semanticscholar   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source