Large-scale simultaneous measurement of epitopes and transcriptomes in single cells
Nature Methods, 2017 High-throughput single-cell RNA sequencing has transformed our understanding of complex cell populations, but it does not provide phenotypic information such as cell-surface protein levels.
Marlon Stoeckius +7 more
semanticscholar +1 more source
CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes [PDF]
, 2006 Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes,
Chan, A. T. C. +8 more
core +1 more source
Frontiers in Microbiology, 2020 In December 2019, the Chinese city of Wuhan was the center of origin of a pneumonia-like disease outbreak with an unknown causative pathogen. The CDC, China, managed to track the source of infection to a novel coronavirus (2019-nCoV; SARS-CoV-2) that ...
Amit Kumar Gupta +20 more
doaj +1 more source
BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes
Nucleic Acids Res., 2017 Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner.
M. C. Jespersen +3 more
semanticscholar +1 more source
Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2
Journal of Human Genetics, 2020 To control and prevent the current COVID-19 pandemic, the development of novel vaccines is an emergent issue. In addition, we need to develop tools that can measure/monitor T-cell and B-cell responses to know how our immune system is responding to this ...
K. Kiyotani +3 more
semanticscholar +1 more source
Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species [PDF]
, 2019 The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough and its contribution to the protein intake in the human diet.
Barro Losada, Francisco +8 more
core +1 more source
Cellular & Molecular Immunology, 2020 Recently, the World Health Organization (WHO) has declared the novel coronavirus (2019-nCoV) outbreak a Public Health Emergency of International Concern (PHEIC), which is now formally named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Ming Zheng, Lun Song
semanticscholar +1 more source
Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data [PDF]
, 2018 Hepatitis C virus (HCV) is a global health issue. Although direct-acting antivirals are available to target HCV, there is currently no vaccine. The diversity of the virus is a major obstacle to HCV vaccine development. One approach toward a vaccine is to
Cowton, Vanessa M. +3 more
core +2 more sources
Potential T-cell and B-cell Epitopes of 2019-nCoV
bioRxiv, 2020 As of early March, 2019-nCoV has infected more than one hundred thousand people and claimed thousands of lives. 2019-nCoV is a novel form of coronavirus that causes COVID-19 and has high similarity with SARS-CoV.
Ethan Fast, R. Altman, Binbin Chen
semanticscholar +1 more source
Antibodies to glycans dominate the host response to schistosome larvae and eggs: Is their role protective or subversive? [PDF]
, 2001 Multiple exposures of chimpanzees to the radiation-attenuated schistosome vaccine provoked a strong parasite-specific cellular and humoral immune response. Specific IgM and IgG were directed mainly against glycans on antigens released by cercariae; these
Coulson, P.S. +7 more
core +1 more source