Functional interplay within the epitranscriptome: Reality or fiction? [PDF]
, 2021 Lina Worpenberg +2 more
openalex +1 more source
PATTERNA: transcriptome-wide search for functional RNA elements via structural data signatures. [PDF]
, 2018 Establishing a link between RNA structure and function remains a great challenge in RNA biology. The emergence of high-throughput structure profiling experiments is revolutionizing our ability to decipher structure, yet principled approaches for ...
Aviran, Sharon, Ledda, Mirko
core
High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq [PDF]
, 2016 High-throughput sequencing has greatly facilitated the discovery of long and short non-coding RNAs (ncRNAs), which frequently guide ribonucleoprotein complexes to RNA targets, to modulate their metabolism and expression.
Gumienny, Rafal +6 more
core +1 more source
Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies [PDF]
, 2020 Next-generation sequencing (NGS) technologies – Illumina RNA-seq, Pacific Biosciences isoform sequencing (PacBio Iso-seq), and Oxford Nanopore direct RNA sequencing (DRS) - have revealed the complexity of plant transcriptomes and their regulation at the ...
Ben-Hur, A. +11 more
core +1 more source
Epitranscriptomic N4-Acetylcytidine Profiling in CD4+ T Cells of Systemic Lupus Erythematosus
Frontiers in Cell and Developmental Biology, 2020 The emerging epitranscriptome plays an essential role in autoimmune disease. As a novel mRNA modification, N4-acetylcytidine (ac4C) could promote mRNA stability and translational efficiency. However, whether epigenetic mechanisms of RNA ac4C modification
Gangqiang Guo +11 more
doaj +1 more source
The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond [PDF]
, 2015 The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation.
Delaney, James C. +4 more
core +1 more source
Modifying gene expression through passive forces
eLifeThe mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
Sarah Hallstein, Julian König
doaj +1 more source
Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]
, 2019 N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng +6 more
core
Epitranscriptomics in normal and malignant hematopoiesis [PDF]
, 2020 Epitranscriptomics analyze the biochemical modifications borne by RNA and their downstream influence. From this point of view, epitranscriptomics represent a new layer for the control of genetic information and can affect a variety of molecular processes
Albano F. +7 more
core +1 more source
Epitranscriptomic code and its alterations in human disease [PDF]
, 2018 Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modifications to date. These developments, together with the recent discovery of writers, readers, and erasers of modifications occurring across a wide range of ...
Janga, Sarath Chandra +1 more
core +1 more source