Results 101 to 110 of about 5,392 (239)

An HIV-1 Reference Epitranscriptome

bioRxiv
Post-transcriptional modifications to RNA, which comprise the epitranscriptome, play important roles in RNA metabolism, gene regulation, and human disease, including viral pathogenesis.
Michael S. Bosmeny, Adrian A. Pater, Li Zhang, Lydia Larkai, Beverly Sha, Zidi Lyu, M. Damha, João I. Mamede, Keith T. Gagnon   +8 more
semanticscholar   +1 more source

WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A‐Dependent Regulation of TP53BP1

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Periodontitis, a chronic inflammatory disease, represents the primary cause of tooth loss in Chinese adults. Wilms tumor 1‐associating protein (WTAP) is a key component of the N6‐methyladenosine (m6A) methyltransferase complex, and has an unclear role in periodontitis pathogenesis, particularly concerning its regulatory functions in
Menglin Xiong, Tingting Wang, Yuan Liu
wiley   +1 more source

The pseudorabies virus UL13 protein kinase triggers phosphorylation of the RNA demethylase FTO, which is associated with FTO-dependent suppression of interferon-stimulated gene expression

Journal of Virology
Alpha-ketoglutarate-dependent dioxygenase, also known as fat mass and obesity-associated protein (FTO), is an RNA demethylase that mediates the demethylation of N6,2-O-dimethyladenosine (m6Am) and N6-methyladenosine (m6A). Both m6Am and m6A are prevalent
Ruth Verhamme, Robert J. J. Jansens, Jianheng Liu, Fien Van Raemdonck, Cliff Van Waesberghe, Luke Nicholson, Samie R. Jaffrey, Herman W. Favoreel   +7 more
doaj   +1 more source

Loss of METTL3 m6A methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients

International Journal of Cancer, Volume 158, Issue 3, Page 763-774, 1 February 2026.
What's new? Bladder cancer exhibits a highly heterogeneous molecular landscape and treatment response. The dysregulation of RNA modifications such as m6A has been involved in cancer initiation and progression. This study comprehensively analyzed the expression of the main catalytic component of the m6A methylation machinery in bladder tumors across one
Katerina‐Marina Pilala, Stella Koroneou, Maria‐Alexandra Papadimitriou, Konstantina Panoutsopoulou, Konstantinos Soureas, Georgios‐Christos Giagkos, Panagiotis Levis, Dimitrios Linardoutsos, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas   +10 more
wiley   +1 more source

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]

, 2019
N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng, Huang, Mengjiang, Li, Dongxu, Lu, Jiuwei, Ren, Wendan, Song, Jikui, Wang, Gang Greg   +6 more
core  

Deciphering mRNA Translation During Sperm Capacitation: A New Frontier in Fertility Research

Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.
ABSTRACT Male infertility accounts for approximately 50% of infertility cases, with nearly 30% remaining unexplained after standard evaluations. This highlights the need for a better understanding of sperm function to advance diagnostic and therapeutic strategies. Sperm were long considered translationally quiescent; however, emerging evidence suggests
Saurabh Tiwari, Nehal Thakor, Jacob Thundathil   +2 more
wiley   +1 more source

Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data [PDF]

, 2013
A large number of computational methods have been developed for analyzing differential gene expression in RNA-seq data. We describe a comprehensive evaluation of common methods using the SEQC benchmark dataset and ENCODE data. We consider a number of key
Azra Krek, Christopher E Mason, Doron Betel, Franck Rapaport, Mono Pirun, Nicholas D Socci, Paul Zumbo, Raya Khanin, Yupu Liang   +8 more
core   +1 more source

Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies [PDF]

, 2020
Next-generation sequencing (NGS) technologies – Illumina RNA-seq, Pacific Biosciences isoform sequencing (PacBio Iso-seq), and Oxford Nanopore direct RNA sequencing (DRS) - have revealed the complexity of plant transcriptomes and their regulation at the ...
Ben-Hur, A., Ben-Hur, A., Dong, S., Dong, S., Gu, L., Gu, L., Huang, J., Huang, J., Reddy, A. S. N., Reddy, A. S. N., Syed, N., Syed, N.   +11 more
core   +1 more source

Getting the Entire Message: Progress in Isoform Sequencing

Frontiers in Genetics, 2019
The advent of second-generation sequencing and its application to RNA sequencing have revolutionized the field of genomics by allowing quantification of gene expression, as well as the definition of transcription start/end sites, exons, splice sites and ...
Simon A. Hardwick, Simon A. Hardwick, Anoushka Joglekar, Paul Flicek, Adam Frankish, Hagen U. Tilgner   +5 more
doaj   +1 more source

The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies

ChemMedChem, Volume 21, Issue 2, January 2026.
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm, Melissa Pieper, Helena Schepers, Andrea Rentmeister   +3 more
wiley   +1 more source