Results 111 to 120 of about 14,810 (242)

A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of aldosterone antagonists for postmyocardial infarction heart failure

Health Technology Assessment, 2010
Background: Two aldosterone inhibitors are currently licensed for heart failure (HF) in the UK: spironolactone and eplerenone. Recent clinical guidelines recommend eplerenone after an acute myocardial infarction (MI) for patients with symptoms and/or ...
C McKenna, J Burch, S Suekarran, S Walker, A Bakhai, K Witte, M Harden, K Wright, N Woolacott, P Lorgelly, L Fenwick, S Palmer   +11 more
doaj   +1 more source

Combination of ADAM17 knockdown with eplerenone is more effective than single therapy in ameliorating diabetic cardiomyopathy

Frontiers in Pharmacology
BackgroundThe renin-angiotensin-aldosterone system (RAAS) members, especially Ang II and aldosterone, play key roles in the pathogenesis of diabetic cardiomyopathy (DCM).
Lin Xie, Dejin Zang, Jianmin Yang, Fei Xue, Wenhai Sui, Yun Zhang, Yun Zhang   +6 more
doaj   +1 more source

56 The impact of statin therapy on the efficacy of eplerenone [PDF]

, 2005
Harvey D. White, John S. Banas, Dirk J. van Veldhuisen, Michael Aschermann, Andrew Koren, Robin Mukherjee, Bertram Pitt   +6 more
openalex   +1 more source

Eplerenone tetrahydrofuran solvate

Acta Crystallographica Section E Structure Reports Online, 2007
The eplerenone mol­ecule of the title compound, C24H30O6·C4H8O, contains three six-membered rings, two five-membered rings and one three-membered ring. In the crystal structure, the eplerenone mol­ecules are linked via C—H⋯O hydrogen bonds, forming a 303 A3 cavity, which is occupied by two disordered solvent THF mol­ecules.
Qian Yang, Wei-Dong Ye, Jian-Yong Yuan, Jing-Jing Nie   +3 more
openaire   +1 more source

Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial

, 2022
Michele Provenzano, María Jesús Puchades, Carlo Garofalo, Niels Jongs, Luis D’Marco, Michele Andreucci, Luca De Nicola, José Luis Górriz, Hiddo J.L. Heerspink   +8 more
openalex   +2 more sources

Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells [PDF]

, 2017
Vascular calcification resulting from hyperphosphatemia is a major determinant of mortality in chronic kidney disease (CKD). Vascular calcification is driven by aldosterone-sensitive osteogenic transformation of vascular smooth muscle cells (VSMCs).
Alesutan, Ioana, Castor, Tatsiana, Feger, Martina, Kratschmar, Denise V., Mia, Sobuj, Sacherer, Michael [u.a.], Voelkl, Jakob   +6 more
core   +1 more source

Eplerenone Inhibits ICAM-1 Production by Macrophages and Macrophage-to-Myofibroblast Transition in Rats with UUO-Induced Type 4 Cardiorenal Syndrome

, 2022
Yutong Han, Yunqian Xian, Panpan Qiang, Juan Hao, Xiaomeng Gao, Fan Yang, Tatsuo Shimosawa, Yi Chang, Qingyou Xu   +8 more
openalex   +1 more source

Remote results of using aldosterone antagonists in complex treatment of patients with myocardial infarction and heart failure [PDF]

, 2015
The work presents remote results of using aldosterone in complex treatment of patients with myocardial infarction combined with heart failure. It is shown that after using of eplerenone the authenticity of renewal functional indexes of myocardium becomes
Gulaga, O.I., Polianska, O.S., Popova, I.S., Tashchuk, V.K.   +3 more
core  

Eplerenone: A Selective Aldosterone Receptor Antagonist (SARA) [PDF]

, 2001
John A. Delyani, Ricardo Rocha, Chyung S. Cook, Dwain Tolbert, Stuart Levin, Barbara Roniker, Diane L. Workman, Yuen‐lung L. Sing, Brian Whelihan   +8 more
openalex   +1 more source

Which drugs should post-MI patients routinely receive? [PDF]

, 2010
patients should be placed on the following medications: antiplatelet agents (strength of recommendation [SOR]: A, meta-analysis for aspirin; A, multiple randomized controlled trials [RCTs] for aspirin plus clopidogrel) a statin; atorvastatin has the best
Holman, John R., Jamieson, Barbara, Lin, Victor   +2 more
core