Results 141 to 150 of about 101,558 (168)

Epoxide hydrolase and hepatocarcinogenesis

Trends in Pharmacological Sciences, 1981
is commonly understood as a nonsynergistic or non-potentiating combination, whereas 'overadditive' is taken as synergism, also expressed as potentiation. The dose-additive method·'·" Table a) by differentiation of additive from overadditive effects allows conclusions about the mechanism of action of A and B.
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Epoxide hydrolase activity of Streptomyces strains

Journal of Biotechnology, 2000
The discovery of epoxide hydrolases within a Streptomyces sp. strain collection is described. Screening was performed in 96 well microtiter plates using a modified 4-(p-nitrobenzyl)pyridine assay with styrene oxide, 1,2-epoxy-hexane or 3-phenyl ethylglycidate (3-PEG) as substrates. Out of 120 strains investigated, S. antibioticus Tü4, S.
Rolf D. Schmid, Uwe T. Bornscheuer, Bernhard Hauer, Markus Enzelberger, Wolfgang Wohlleben, Frank Zocher   +5 more
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Spectrophotometric Substrates for Cytosolic Epoxide Hydrolase

Analytical Biochemistry, 1994
In this study, we demonstrate the utility of a broad class of spectrophotometric substrates for the assay of cytosolic epoxide hydrolase purified from murine liver. These substrates, epoxy esters or carbonates, cyclize spontaneously upon or during hydrolysis of the epoxide functionality.
Bruce D. Hammock, Eiichi Kuwano, Eric C. Dietze   +2 more
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Epoxide Hydrolase in Human Fetal Liver

Pharmacology, 1983
Epoxide hydrolase activity towards styrene oxide was measured in the microsomal fraction of 20 human fetal livers. The enzymatic activity was 5.60 +/- 0.52 nmol/min/mg (mean +/- SE) which is about 40% of the previously reported value in human adult liver microsomes. No relation between enzymatic activity and fetal age was observed.
Anders Rane, Gian Maria Pacifici
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A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.

Journal of Medicinal Chemistry, 2017
Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by accumulation of fat in liver causing inflammation and fibrosis.
Jurema Schmidt, Marco J Rotter, T. Weiser, Sandra K. Wittmann, L. Weizel, A. Kaiser, J. Heering, T. Goebel, C. Angioni, M. Wurglics, A. Paulke, G. Geisslinger, A. Kahnt, D. Steinhilber, E. Proschak, D. Merk   +15 more
semanticscholar   +1 more source

Soluble epoxide hydrolase and ischemic cardiomyopathy

International Journal of Cardiology, 2012
The development of cardiovascular disease has been linked to lowered levels of epoxyeicosatrienoic acids (EETs) in the cardiovascular system. Ischemic cardiomyopathy is caused by atherosclerotic lesions in multi-coronary arteries especially diffusive lesions, which can lead to severe myocardial dysfunction, heart enlargement, heart failure, or ...
Shui-ping Zhao, Binaya Wasti, Li Shen, Jian-qing Du, Danyan Xu, Ting-ting Zhao   +5 more
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Metabolism of epoxidized phosphatidylcholine by phospholipase A₂ and epoxide hydrolase

Lipids, 1981
AbstractThe isolation and measurement of phospholipid epoxides as major peroxidation products in biomembrane preparations prompted an investigation of enzymatic mechanisms which may be responsible for their elimination. Analysis of microsomal epoxide hydrolase and phospholipase A2 activity against a phospholipid epoxide commonly encountered in tissues ...
Robert A. Stein, James F. Mead, Alex Sevanian   +2 more
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Epoxide hydrolase — polymorphism and role in toxicology

Toxicology Letters, 2000
Microsomal epoxide hydrolase is a critical biotransformation enzyme that catalyzes the conversion of a broad array of xenobiotic epoxide substrates to more polar diol metabolites. The gene has been shown previously to exhibit polymorphism, including variation in the coding region leading to amino acid substitutions at positions 113 (Y/H) and 139 (H/R).
Curtis J. Omiecinski, Christopher Hassett, Vinayak Hosagrahara   +2 more
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The role of soluble epoxide hydrolase in preeclampsia

Medical Hypotheses, 2017
Preeclampsia is a serious complication of pregnancy characterized by the development of vasospasm, hypertension and often associated with proteinuria after the 20th week of gestation. Because termination of pregnancy results in the most efficacious resolution of preeclampsia, it is a leading cause of premature delivery worldwide.
Julia M. Santos, Jung-A. Park, Aby Joiakim, David A. Putt, Robert N. Taylor, Hyesook Kim   +5 more
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ChemInform Abstract: Epoxide Hydrolases as Asymmetric Catalysts

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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