Results 61 to 70 of about 14,919 (226)

GMPPB‐CDG Results in Lysosomal Dysfunction and Acid Alpha‐Glucosidase Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT GDP‐mannose pyrophosphorylase B (GMPPB) deficiency is a congenital disorder of glycosylation due to pathogenic variants of the GMPPB gene. GMPPB catalyzes GDP‐mannose synthesis, an early step in multiple glycosylation pathways, including N‐glycosylation, O‐mannosylation, C‐mannosylation, and glycosylphosphatidylinositol‐anchor formation.
Carla Damiano, Antonietta Tarallo, Vincenza Gragnaniello, Sandra Strollo, Simona Fecarotta, M. Rosaria Tuzzi, Elena Polishchuk, Sandro Montefusco, Anna Valanzano, Antonia Assunto, Nadia Minopoli, Roberto Della Casa, Roman Polishchuk, Stijn L. M. in 't Groen, Diego Luis Medina, Enrico Bertini, Rosalba Carrozzo, Julia Emmerich, Benedikt Schoser, W. W. M. Pim Pijnappel, Giancarlo Parenti   +20 more
wiley   +1 more source

Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage

New Phytologist, Volume 249, Issue 2, Page 892-916, January 2026.
Summary Plant lipid droplets (LDs) and their associated proteins have numerous subcellular and physiological functions. While considerable progress has been made for LDs in many tissues, the function and composition of LDs in roots remain largely unexplored.
Patricia Scholz, Janis Dabisch, Ana C. Vilchez, Alyssa C. Clews, Philipp W. Niemeyer, Magdiel S. S. Lim, Siqi Sun, Lea Hembach, Mayuko Naganawa, Fabienne Dreier, Katharina F. Blersch, Lea M. Preuß, Martin Bonin, Elena Lesch, Yuya Iwai, Takashi L. Shimada, Jürgen Eirich, Iris Finkemeier, Katharina Gutbrod, Peter Dörmann, You Wang, Robert T. Mullen, Till Ischebeck   +22 more
wiley   +1 more source

Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice [PDF]

, 2021
Yang Yang, Xinyun Xu, Haoying Wu, Jun Yang, Jiangang Chen, Christophe Morisseau, Bruce D. Hammock, Ahmed Bettaieb, Ling Zhao   +8 more
openalex   +1 more source

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, Volume 24, Issue 1, Page 99-130, January 2026.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Human genetics and real‐world patient data fuel target and drug discovery in Alzheimer's disease using Artificial Intelligence

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Although high‐throughput DNA/RNA sequencing technologies from the NIA‐funded Alzheimer's disease sequencing project (ADSP) have generated massive genetic and genomic data in human disease, translation of these findings into new patient treatment has not materialized by lack of effective approaches, such as Artificial Intelligence ...
Feixiong Cheng, Yuan Hou, Andrew A. Pieper, Jonathan L Haines, Jeffrey L. Cummings   +4 more
wiley   +1 more source

Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme

IUCrJ, 2018
The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenylpropane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product ...
Åsa Janfalk Carlsson, Paul Bauer, Doreen Dobritzsch, Shina C. L. Kamerlin, Mikael Widersten   +4 more
doaj   +1 more source

Lipoprotein‐Mediated Esterified Oxylipins Changed in Alzheimer's Disease

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Inflammation is crucial in Alzheimer's Disease (AD) pathology, with oxylipins – oxidized lipid derivatives of polyunsaturated fatty acids – serving as potent modulators. Particularly, dysregulation of soluble epoxide hydrolase (sEH), which converts pro‐resolving epoxides to pro‐inflammatory diols, has been observed in blood and ...
Sitong Zhou, Kamil Borkowski, Angela M. Zivkovic, Izumi Maezawa, John W. Newman, Lee‐Way Jin   +5 more
wiley   +1 more source

epoxide hydrolase

Citation: 'epoxide hydrolase' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10676 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids

Frontiers in Pharmacology
Arachidonic acid (AA) has three main metabolic pathways: the cycloxygenases (COXs) pathway, the lipoxygenases (LOXs) pathway, and the cytochrome P450s (CYPs) pathway. AA produces epoxyeicosatrienoic acids (EETs) through the CYPs pathway.
Shan Jiang, Shan Jiang, Siyi Han, Dao Wen Wang, Dao Wen Wang   +4 more
doaj   +1 more source