Results 11 to 20 of about 6,873 (191)

Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function [PDF]

Journal of Lipid Research, 2018
Lipoxygenase (LOX)-catalyzed oxidation of the essential fatty acid, linoleate, represents a vital step in construction of the mammalian epidermal permeability barrier.
Haruto Yamanashi, William E. Boeglin, Christophe Morisseau, Robert W. Davis, Gary A. Sulikowski, Bruce D. Hammock, Alan R. Brash   +6 more
doaj   +2 more sources

Improving Hydrolytic Activity and Enantioselectivity of Epoxide Hydrolase from Phanerochaete chrysosporium by Directed Evolution [PDF]

Molecules
Epoxide hydrolases (EHs) catalyze the conversion of epoxides into vicinal diols. The epoxide hydrolase gene from P. chrysosporium was previously cloned and subjected to site-directed mutation to study its enzyme activity, but the results were ...
Huanhuan Shao, Pan Xu, Xiang Tao, Xinyi He, Chunyan Pu, Shaorong Liang, Yingxin Shi, Xiaoyan Wang, Hong Feng, Bin Yong   +9 more
doaj   +2 more sources

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]

Physiological Reviews, 2012
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
John D. Imig
openaire   +4 more sources

Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases [PDF]

mBio, 2017
Michael Arand, Anne Marowsky
doaj   +2 more sources

Reply to “Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases” [PDF]

mBio, 2017
Daniel E. Goldberg, Natalie J. Spillman
doaj   +2 more sources

Corrigendum to “Structure–function relationship between soluble epoxide hydrolases structure and their tunnel network” [Comput. Struct. Biotechnol. J. 20 (2022) 193–205] [PDF]

Computational and Structural Biotechnology Journal, 2022
Karolina Mitusińska, Piotr Wojsa, Maria Bzówka, Agata Raczyńska, Weronika Bagrowska, Aleksandra Samol, Patryk Kapica, Artur Góra   +7 more
doaj   +2 more sources

P2-HNF4α alters linoleic acid metabolism and mitigates soybean oil-induced obesity: role for oxylipins [PDF]

Journal of Lipid Research
Oxylipins—oxidized metabolites of polyunsaturated fatty acids (PUFAs)—are associated with several pathological conditions. We previously showed that oxylipin metabolites of linoleic acid (LA) and alpha-linolenic acid positively correlate with obesity in ...
Poonamjot Deol, Johannes Fahrmann, Dmitry Grapov, Jun Yang, Jane R. Evans, Oliver Fiehn, Brett Phinney, Bruce D. Hammock, Frances M. Sladek   +8 more
doaj   +2 more sources

Transcriptomic profiling of Debaryomyces hansenii reveals detoxification and stress responses to benzo(a)pyrene exposure [PDF]

Applied and Environmental Microbiology
The environmental accumulation of polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), poses significant threats to ecosystems and public health due to their persistent nature, mutagenic potential, and well-documented carcinogenicity ...
Francisco Padilla-Garfias, Augusto César Poot-Hernández, Minerva Araiza-Villanueva, Martha Calahorra, Norma Silvia Sánchez, Antonio Peña   +5 more
doaj   +2 more sources

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

eLife, 2021
Epoxide hydrolases (EHs) regulate cellular homeostasis through hydrolysis of epoxides to less-reactive diols. The first discovered EH was EPHX1, also known as mEH.
Jeremie Gautheron, Christophe Morisseau, Wendy K Chung, Jamila Zammouri, Martine Auclair, Genevieve Baujat, Emilie Capel, Celia Moulin, Yuxin Wang, Jun Yang, Bruce D Hammock, Barbara Cerame, Franck Phan, Bruno Fève, Corinne Vigouroux, Fabrizio Andreelli, Isabelle Jeru   +16 more
doaj   +1 more source

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

Journal of Lipid Research, 2012
Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker, Magdalena Adamska, Annette Cronin, Francesca Di Giallonardo, Julia Burgener, Anne Marowsky, John R. Falck, Christophe Morisseau, Bruce D. Hammock, Artiom Gruzdev, Darryl C. Zeldin, Michael Arand   +11 more
doaj   +1 more source