Soluble Epoxide Hydrolase and Diabetes Complications
International Journal of Molecular Sciences, 2022 Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke.
Natasha Z. Anita, Walter Swardfager
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Improvement of the Epoxide Hydrolase Properties for the Enantioselective Hydrolysis of Epoxides
Current Organic Chemistry, 2013 Peer ...
Solares, L. F., Mateo González, César
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Epoxide hydrolases: biochemistry and molecular biology [PDF]
Chemico-Biological Interactions, 2000 Epoxides are organic three-membered oxygen compounds that arise from oxidative metabolism of endogenous, as well as xenobiotic compounds via chemical and enzymatic oxidation processes, including the cytochrome P450 monooxygenase system. The resultant epoxides are typically unstable in aqueous environments and chemically reactive.
Curtis J. Omiecinski, Adrian J. Fretland
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Effect of Binding on Enantioselectivity of Epoxide Hydrolase [PDF]
Journal of Chemical Information and Modeling, 2018 Molecular dynamics simulations and free energy calculations have been used to investigate the effect of ligand binding on the enantioselectivity of an epoxide hydrolase (EH) from Aspergillus niger. Despite sharing a common mechanism, a wide range of alternative mechanisms have been proposed to explain the origin of enantiomeric selectivity in EHs.
Julian Zaugg +4 more
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Human liver cytosolic epoxide hydrolases [PDF]
European Journal of Biochemistry, 1988 Human liver epoxide hydrolases were characterized by several criteria and a cytosolic cis‐stilbene oxide hydrolase (cEHcso) was purified to apparent homogeneity.Styrene oxide and five phenylmethyloxiranes were tested as substrates for human liver epoxide hydrolases.
Ludwig Schladt +3 more
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Cloning and Characterization of Drosophila melanogaster Juvenile Hormone Epoxide Hydrolases (JHEH) and Their Promoters. [PDF]
Biomolecules, 2022 Borovsky D +6 more
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Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network. [PDF]
Comput Struct Biotechnol J, 2022 Mitusińska K +7 more
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Evolution of tunnels in α/β-hydrolase fold proteins-What can we learn from studying epoxide hydrolases? [PDF]
PLoS Comput Biol, 2022 Bzówka M +7 more
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Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases. [PDF]
Front Bioeng Biotechnol, 2022 Zhang D +5 more
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Corrigendum to "Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network" [Comput. Struct. Biotechnol. J. 20 (2022) 193-205]. [PDF]
Comput Struct Biotechnol J, 2022 Mitusińska K +7 more
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