Results 21 to 30 of about 6,873 (191)

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial ...
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Gavin Y. Oudit, John M. Seubert, John M. Seubert, John M. Seubert   +15 more
doaj   +1 more source

Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity

Data in Brief, 2016
The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira, Patricia Pereira Adriani, Flavia Garcia Borges, Adriana Rios Lopes, Patricia T. Campana, Felipe S. Chambergo   +5 more
doaj   +1 more source

The role of soluble epoxide hydrolase and its inhibitors in depression

Brain, Behavior, & Immunity - Health, 2021
Evidence suggests that around 30 ​% of patients with depression do not respond to antidepressant treatment, with most of them having sub-chronic levels of inflammation.
Alessandra Borsini
doaj   +1 more source

Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's Disease and Other Neurological Disorders: A Comprehensive Review. [PDF]

Biomedicines
Abdalla M, Ibrahim M, Alkorbi N, Alkuwari S, Pedersen S, Rathore HA.   +5 more
europepmc   +3 more sources

Detoxication Strategy of Epoxide Hydrolase—The Basis for a Novel Threshold for Definable Genotoxic Carcinogens

Dose-Response, 2004
From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed.
Franz Oesch, Jan Georg Hengstler, Michael Arand   +2 more
doaj   +1 more source

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source

Is Promiscuous CALB a Good Scaffold for Designing New Epoxidases?

Molecules, 2015
Candida Antarctica lipase B (CALB) is a well-known enzyme, especially because of its promiscuous activity. Due to its properties, CALB was widely used as a benchmark for designing new catalysts for important organic reactions.
Isabel Bordes, José Recatalá, Katarzyna Świderek, Vicent Moliner   +3 more
doaj   +1 more source

Microsomal epoxide hydrolase polymorphisms

Molecular Medicine Reports, 2010
Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change tyrosine residue 113 to histidine (Tyr113His) and histidine 139 to arginine (His139Arg), respectively.
Pinarbasi, Hatice, Silig, Yavuz, Pinarbasi, Ergun   +2 more
openaire   +5 more sources

A Genomic and Transcriptomic Study on the DDT-Resistant Trichoderma hamatum FBL 587: First Genetic Data into Mycoremediation Strategies for DDT-Polluted Sites

Microorganisms, 2021
Trichoderma hamatum FBL 587 isolated from DDT-contaminated agricultural soils stands out as a remarkable strain with DDT-resistance and the ability to enhance DDT degradation process in soil.
Domenico Davolos, Fabiana Russo, Loredana Canfora, Eligio Malusà, Małgorzata Tartanus, Ewa Maria Furmanczyk, Andrea Ceci, Oriana Maggi, Anna Maria Persiani   +8 more
doaj   +1 more source

Anti-tubercular activity of a natural stilbene and its synthetic derivatives

GMS Infectious Diseases, 2018
Objectives: Tuberculosis (TB) and multidrug- and extensively drug-resistant TB in particular are remaining a major global health challenge and efficient new drugs against TB are needed.
Reinheimer, Claudia, Büttner, Dominik, Proschak, Eugen, Bode, Helge B., Kempf, Volkhard A. J., Wichelhaus, Thomas A.   +5 more
doaj   +1 more source