Results 31 to 40 of about 6,873 (191)

Soluble Epoxide Hydrolase in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2010
Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim, Ulu, Arzu, Zhang, Le-Ning, Hammock, Bruce   +3 more
openaire   +4 more sources

Transcriptomic analyses reveal increased expression of dioxygenases, monooxygenases, and other metabolizing enzymes involved in anthracene degradation in the marine alga Ulva lactuca

Frontiers in Plant Science, 2022
To analyze the mechanisms involved in anthracene (ANT) degradation in the marine alga Ulva lactuca, total RNA was obtained from the alga cultivated without ANT and with 5 μM of ANT for 24 h, and transcriptomic analyses were performed.
Alberto González, Héctor Osorio, Stephanie Romero, Patricia Méndez, Muriel Sepúlveda, Daniel Laporte, Marlen Gutierrez-Cutiño, Rocío Santander, Eduardo Castro-Nallar, Eduardo Castro-Nallar, Alejandra Moenne   +10 more
doaj   +1 more source

Gut microbiome-derived hydrolases—an underrated target of natural product metabolism

Frontiers in Cellular and Infection Microbiology
In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases in relation to oral drug metabolism, particularly focusing on natural product drugs.
Jiaxin He, Xiaofeng Liu, Junming Zhang, Rong Wang, Xinyuan Cao, Xinyuan Cao, Ge Liu   +6 more
doaj   +1 more source

Human liver cytosolic epoxide hydrolases [PDF]

European Journal of Biochemistry, 1988
Human liver epoxide hydrolases were characterized by several criteria and a cytosolic cis‐stilbene oxide hydrolase (cEHcso) was purified to apparent homogeneity.Styrene oxide and five phenylmethyloxiranes were tested as substrates for human liver epoxide hydrolases.
L, Schladt, H, Thomas, R, Hartmann, F, Oesch   +3 more
openaire   +2 more sources

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Enantiomeric Tartaric Acid Production Using cis-Epoxysuccinate Hydrolase: History and Perspectives

Molecules, 2019
Tartaric acid is an important chiral chemical building block with broad industrial and scientific applications. The enantioselective synthesis of l(+)- and d(−)-tartaric acids has been successfully achieved using bacteria presenting cis ...
Jinsong Xuan, Yingang Feng
doaj   +1 more source

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
wiley   +1 more source

Exploring Solanum tuberosum Epoxide Hydrolase Internal Architecture by Water Molecules Tracking

Biomolecules, 2018
Several different approaches are used to describe the role of protein compartments and residues in catalysis and to identify key residues suitable for the modification of the activity or selectivity of the desired enzyme.
Karolina Mitusińska, Tomasz Magdziarz, Maria Bzówka, Agnieszka Stańczak, Artur Góra   +4 more
doaj   +1 more source

A first insight into Pycnoporus sanguineus BAFC 2126 transcriptome. [PDF]

PLoS ONE, 2013
Fungi of the genus Pycnoporus are white-rot basidiomycetes widely studied because of their ability to synthesize high added-value compounds and enzymes of industrial interest.
Cristian O Rohr, Laura N Levin, Alejandro N Mentaberry, Sonia A Wirth   +3 more
doaj   +1 more source