Results 131 to 140 of about 4,873 (155)

20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure

Current Opinion in Nephrology and Hypertension, 2001
The properties of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids, vasoactivity and modulation of ion transport and mediation/modulation of the effects of vasoactive hormones, such as angiotensin II and endothelin, underscore their importance to renal vascular mechanisms and electrolyte excretion.
J C, McGiff, J, Quilley
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Epoxyeicosatrienoic acids, cell signaling and angiogenesis

Prostaglandins & Other Lipid Mediators, 2007
Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases the expression of which is determined by hemodynamic and pharmacological stimuli as well as by hypoxia. The activation of CYP epoxygenases in endothelial cells is an important step in the vasodilatation that has been attributed to the endothelium ...
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Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy

Trends in Pharmacological Sciences, 2016
Cardiovascular disease remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising strategy involves epoxyeicosatrienoic acid (EET) and soluble epoxide hydroxylase (sEH) inhibition. sEH is the enzyme that converts EET to its less potent metabolite; therefore, EET is upregulated by its ...
Mikhail, Romashko, Joseph, Schragenheim, Nader G, Abraham, John A, McClung   +3 more
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Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

Progress in Lipid Research, 2004
Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in the cardiovascular system and kidney. They modulate ion transport and gene expression, producing vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.
Arthur A, Spector, Xiang, Fang, Gary D, Snyder, Neal L, Weintraub   +3 more
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Effects of epoxyeicosatrienoic acids on polymorphonuclear leukocyte function

Life Sciences, 2002
During periods of ischemia and vascular injury, factors are released which recruit monocytes and polymorphonuclear leukocytes (PMNs) to the site of injury by promoting adherence to the endothelium and transmigration across the endothelial cell (EC) layer.
Phillip F, Pratt, Mark, Rosolowsky, William B, Campbell   +2 more
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Epoxyeicosatrienoic Acid Pathway in Human Health and Diseases

Journal of Cardiovascular Pharmacology, 2013
In response to endothelial cell activation, arachidonic acid can be converted by cytochrome P450 (CYP) epoxygenases to epoxyeicosatrienoic acids (EETs), which have potent vasodilator and anti-inflammatory properties. EETs are rapidly degraded in vivo to the less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH).
Jeremy, Bellien, Robinson, Joannides
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Dual Regulation of the Cerebral Microvasculature by Epoxyeicosatrienoic Acids

Trends in Cardiovascular Medicine, 2001
Epoxyeicosatrienoic acids (EETs) are lipid metabolites that are synthesized in vascular endothelial cells. They are released by stimulation of their muscarinic receptors, and induce vaso-relaxation of cerebral blood vessels. In addition, cytochrome P450 epoxygenase enzymes, which catalyze the formation of epoxyeicosatrienoic acids, especially after ...
M, Medhora, J, Narayanan, D, Harder
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Potentiation of Endothelium-Dependent Relaxation by Epoxyeicosatrienoic Acids

Circulation Research, 1997
AbstractEpoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome P-450 metabolism of arachidonic acid. EETs and their diol products (DHETs) are also avidly taken up by endothelial cells and incorporated into phospholipids that participate in signal transduction.
N L, Weintraub, X, Fang, T L, Kaduce, M, VanRollins, P, Chatterjee, A A, Spector   +5 more
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Determination of 14,15-Epoxyeicosatrienoic Acid and 14,15-Dihydroxyeicosatrienoic Acid by Fluoroimmunoassay

Analytical Biochemistry, 1997
A fluoroimmunoassay (FIA) for 14,15-epoxyeicosatrienoic acid (14,15-EET) and 14,15-dihydroxyeicosatrienoic acid (14,15-DHET), cytochrome P450 epoxygenase products of arachidonic acid, was developed using fluorescence polarization. 14-15-EET was hydrolyzed and analyzed as 14,15-DHET. 14,15-DHET was conjugated to thyroglobulin and a specific antibody was
K, Nithipatikom, J R, Falck, R K, Bhatt, C J, Hanke, W B, Campbell   +4 more
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Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
Epoxyeicosatrienoic acids, metabolites of the cytochrome P-450-mediated epoxygenase reaction, were detected in human urine by gas chromatographic-mass spectroscopic techniques after conversion to their hydrogenated and non-hydrogenated methyl and pentafluorobenzyl esters.
R, Toto, A, Siddhanta, S, Manna, B, Pramanik, J R, Falck, J, Capdevila   +5 more
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