Results 121 to 130 of about 4,873 (155)

Epoxyeicosatrienoic acids regulate macrophage polarization and prevent LPS-induced cardiac dysfunction. [PDF]

J Cell Physiol, 2015
Dai M, Wu L, He Z, Zhang S, Chen C, Xu X, Wang P, Gruzdev A, Zeldin DC, Wang DW.   +9 more
europepmc   +1 more source

Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia.

J Appl Physiol (1985), 2015
Liu X, Gebremedhin D, Harder DR, Koehler RC.   +3 more
europepmc   +1 more source

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Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites

Analytical Biochemistry, 2006
An HPLC method for the chiral analysis of the four regioisomeric epoxyeicosatrienoic acids (EETs) is described. The cytochrome P450 arachidonic acid epoxygenase metabolites are resolved, without the need for derivatization, by chiral-phase HPLC on a Chiralcel OJ column.
J R Falck, Jorge H Capdevila, Kasem Nithipatikom   +2 more
exaly   +3 more sources

Role of epoxyeicosatrienoic acids in the lung

Prostaglandins & Other Lipid Mediators, 2020
Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs). The effects of EETs on cardiovascular function, the nervous system, the kidney and metabolic disease have been reviewed. In the lungs, the presence of these CYPs and EETs has been documented.
Hugo F, Olivares-Rubio, J J, Espinosa-Aguirre   +1 more
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Neuroprotective effects of epoxyeicosatrienoic acids

Prostaglandins & Other Lipid Mediators, 2018
Eicosatrienoic acids (EETs) are a class of intermediates produced during arachidonic acid metabolism mediated by cytochrome P450 epoxygenases that exert multiple physiological effects on the nervous system. EETs promote three metabolic processes, including esterification, hydrolysis and degradation or extension.
Lai, Wang, Gan, Luo, Long-Fei, Zhang, Hui-Xia, Geng   +3 more
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Collisionally induced dissociation of epoxyeicosatrienoic acids and epoxyeicosatrienoic acid-phospholipid molecular species

Analytical Biochemistry, 1991
Four isomers of epoxyeicosatrienoic acid (EET) can be formed by cytochrome P-450 oxidation of arachidonic acid: 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid. The collision-induced dissociation of the [M-H]- anion at m/z 319 from each of these isomers, using negative-ion fast atom bombardment ionization and a triple quadrupole mass ...
K, Bernstrom, K, Kayganich, R C, Murphy
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Action of epoxyeicosatrienoic acids on cellular function

American Journal of Physiology-Cell Physiology, 2007
Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by cytochrome P-450 epoxygenases. They activate smooth muscle large-conductance Ca2+-activated K+ channels, producing hyperpolarization and vasorelaxation.
Arthur A, Spector, Andrew W, Norris
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Influence of epoxyeicosatrienoic acids on uterine function

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1997
In spite of the large quantities of epoxyeicosatrienoic acids (EEts) released by reproductive tissues, their function has not yet been determined. In order to analyze the influence of epoxygenase products on isolated uterine function, Clotrimazole, a cytochrome P450 inhibitor was used. The drug decreased isolated rat uterine isometric developed tension
E, Gonzalez, A, Jawerbaum, V, Novaro, M A, Gimeno   +3 more
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Erythrocyte-derived epoxyeicosatrienoic acids

Prostaglandins & Other Lipid Mediators, 2007
Red blood cells (RBCs) are reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs) that can be released. The sources of EET release from RBCs include direct synthesis from arachidonic acid, peroxidation of phospholipids and EETs esterified into cellular phospholipids. The release of EETs from RBCs can be through cytosolic phospholipase A2 (PLA2),
openaire   +2 more sources

Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension

Current Opinion in Nephrology and Hypertension, 2004
Cytochrome P-450 metabolites of arachidonic acid have been reported to play an important role in the control of renal function and vascular tone, and in the long-term control of arterial pressure. In this regard, 20-hydroxyeicosatetraenoic acid is a potent vasoconstrictor that inhibits sodium reabsorption in the kidney.
Albert, Sarkis, Bernardo, Lopez, Richard J, Roman   +2 more
openaire   +2 more sources