Results 51 to 60 of about 18,955 (239)

Physiological and Metabolic Responses of Marine Mussels Exposed to Toxic Cyanobacteria Microcystis aeruginosa and Chrysosporum ovalisporum [PDF]

, 2020
Toxic cyanobacterial blooms are a major contaminant in inland aquatic ecosystems. Furthermore, toxic blooms are carried downstream by rivers and waterways to estuarine and coastal ecosystems. Concerning marine and estuarine animal species, very little is
Azevedo, Joana, Barreiro, Aldo, Cameán Fernández, Ana María, Campos, Alexandre, Díez-Quijada Jiménez, Leticia, Jos Gallego, Ángeles Mencía, Martins, José Carlos, Moraes, Joao-Paulo, Oliveira, Flavio, Turkina, Maria V., Vasconcelos, Vitor   +10 more
core   +1 more source

High-affinity binding of Clostridium perfringens epsilon-toxin to rat brain [PDF]

Infection and Immunity, 1992
125I-epsilon-toxin showed high affinity to rat brain homogenates and synaptosomal membrane fractions, having single binding phases with dissociation constants (Kds) of 2.5 and 3.3 nM, respectively. Treatment of synaptosomal membrane fractions with pronase and neuraminidase lowered the binding of the labeled toxin, whereas treatment with trypsin and ...
M, Nagahama, J, Sakurai
openaire   +2 more sources

Spatial Patterning of Modular Gelatin‐Peroxide Microspheres in Melt‐Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity

Advanced Healthcare Materials, EarlyView.
A bioassembly approach is described using photo‐crosslinked gelatin‐based microgels containing calcium peroxide (CaO2) to generate oxygen (O2) and enhance cell survival in hypoxic conditions (1% O2). Bioassembly enables spatial patterning of individual CaO2‐laden and mesenchymal stem cell (MSC)‐laden microgels and allows for decoupling and mitigating ...
Axel E. Norberg, F. Max Yavitt, Ezgi Bakirci, Khoon Lim, Tim B. F. Woodfield, Gabriella C. J. Lindberg   +5 more
wiley   +1 more source

Calcium enhances binding of Clostridium perfringens epsilon toxin to sulfatide

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2019
Epsilon toxin (Etx) from Clostridium perfringens is synthesized as a very low-active prototoxin form (proEtx) that becomes active upon proteolytic activation and has the capacity to cross the blood-brain barrier (BBB), thereby producing severe neurological effects.
C, Gil, J, Dorca-Arévalo, J, Blasi
openaire   +2 more sources

Effect of Clostridium perfringens Epsilon Toxin on Rat Isolated Aorta [PDF]

Microbiology and Immunology, 1993
AbstractThe effect of Clostridium perfringens epsilon toxin on rat isolated aorta was investigated. The toxin caused contraction of the isolated aorta in a dose‐dependent manner. The toxin induced no contraction of the isolated aorta in low‐Na medium and of the tissue stored at 4 C for 7 days.
M, Nagahama, H, Iida, J, Sakurai
openaire   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]

, 2014
Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core   +1 more source

Hybrid Nanofibers for Multimodal Accelerated Wound Healing

Advanced Healthcare Materials, EarlyView.
Fabrication of wound healing scaffolds based on biocompatible nanofibers. Nanofibers offering high surface area, flexibility, and biocompatibility significantly improved the healing outcome in vivo. Histological, immunological, and anti‐inflammatory markers are noticeably better in treated wounds.
Viraj P. Nirwan, Bence Bajusz, Norbert Fabók, Marina Rudan Dimlic, Jelena Budimir, Tshepang Mqatywa, Miklós Gyöngy, Márton Ferencz, Dorottya Kocsis, Olexandr Bondarenko, Mariia Rolduhina, Milena Lengyel, Istvan Antal, Rebecca Hengsbach, Franciska Erdő, Amir Fahmi   +15 more
wiley   +1 more source

A Personalized, 3D Printed Polymeric Device for the Prevention of Post‐Myocardial Infarction Cardiac Remodeling

Advanced Healthcare Materials, EarlyView.
Myocardial infarction often leads to pathological remodelling and ventricular dilatation, key features of HFrEF. This study introduces a personalized, 3D‐printed cardiac restraint device (CARD) printed using rationally designed inks displaying the requested printability and mechanical properties.
Nicola Mansour, Daniel Cohn, Ishita Sarkar, Raja Alamore, Kareem Abd Rbo, Offer Amir, Dean Nachman   +6 more
wiley   +1 more source

Biochemical and Pharmacological Studies of Clostridium perfringens .EPSILON.-Toxin.

Nippon Saikingaku Zasshi, 1996
D型ウエルシュ菌のe毒素は, 致死, 壊死作用を有するタンパク毒素で, 本菌によるヒツジの腸性中毒症の病原因子と考えられている。本研究では, e毒素の作用機構解明の手がかりを得るため, e毒素の in vivo と in vitro における作用, さらに構造と機能について検討した。まず, e毒素をラットに投与すると末梢血管の収縮による急激な血圧上昇が認められること, さらに本毒素は, in vitro で血管, 回腸などの摘出平滑筋組織を収縮させることを明らかにした。この作用は毒素が神経系にNa+の流入を促進し, その結果, 神経伝達物質が遊離, そしてCa2+チャンネルが活性化されて引き起こされることが判明した。一方, e毒素は脳組織において1種類のシアロ糖タンパク質に特異的に結合すること ...
openaire   +3 more sources