Results 91 to 100 of about 1,882,229 (349)

Primary Epstein-Barr virus infection in a 40-day-old infant [PDF]

, 2013
Most cases of primary Epstein-Barr virus (EBV) infection during infancy and early childhood are mild or subclinical; therefore, the diagnosis of an EBV infection is not performed easily in this age group.
Aminolsharieh Najafi, S., Hasheminejad, R., Tafreshi, M.   +2 more
core   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

The Diagnosis of Epstein-Barr Virus-Associated Polymorphic B Cell Lymphoma in Immunocompromised Patients: Review of Methods

Canadian Journal of Infectious Diseases, 1991
Polymorphic B cell lymphoma and diffuse B cell lymphoproliferation associated with Epstein-Barr virus infection is increasingly reported in immunodeficient patients.
Pierre Beauparlant, Caroline Alfieri, Jean-Harry Joncas   +2 more
doaj   +1 more source

Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: Transmission by donated organ and the effect of OKT3 antibodies [PDF]

, 1988
One hundred twenty-one adult liver transplant recipients were studied for the incidence, risk factors, and morbidity associated with herpesviruses infections after transplantation. The overall incidence of infection was 59% for cytomegalovirus (CMV), 35%
Armstrong, JA, Breinig, MK, Dummer, JS, Ho, M, Kusne, S, Makowka, L, Singh, N, Starzl, TE   +7 more
core   +1 more source

Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth

Science Translational Medicine, 2019
EBNA1 inhibitors developed by fragment-based drug design block EBNA1 DNA binding and EBV-dependent tumor cell growth in vivo. No holds Barr-ed for cancer treatment Persistent latent infection with Epstein-Barr virus contributes to tumorigenesis in a ...
T. Messick, Garry R. Smith, S. Soldan, M. McDonnell, J. Deakyne, K. Malecka, Lois E Tolvinski, A. Pieter J. van den Heuvel, Baiwei Gu, J. Cassel, Donna H Tran, Benjamin R. Wassermann, Yan Zhang, Venkata Velvadapu, E. Zartler, P. Busson, A. Reitz, P. Lieberman   +17 more
semanticscholar   +1 more source

DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR‐JAK2‐STAT3 Pathway

Advanced Science, EarlyView.
This study identifies a novel mechanism of nasopharyngeal carcinoma (NPC) cisplatin chemoresistance that DDAH1 expression is associated with cisplatin resistance in NPC cells primarily through the enhancement of the phosphoinositide Janus kinase 2 (JAK2)‐signal transducer and activator of transcription 3 (STAT3) pathway.
Jin‐Hao Yang, Li Yuan, Qiu‐Yan Chen, Kai‐Qi Lan, Liang‐Ji Li, Yu‐Chen Li, Xiao‐Yun Li, Xue‐Song Sun, Lin‐Quan Tang, Sai‐Lan Liu, Hai‐Qiang Mai   +10 more
wiley   +1 more source

Evaluation of reactive Epstein-Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)

Brazilian Journal of Infectious Diseases, 2013
OBJECTIVES: Epstein-Barr virus has been recently associated with the onset of multiple sclerosis, yet understanding how it elicits autoimmunity remains elusive.
Nourollah Ramroodi, Abbas Ali Niazi, Nima Sanadgol, Zohre Ganjali, Vida Sarabandi   +4 more
doaj   +2 more sources

Novel Therapeutics for Epstein–Barr Virus

Molecules, 2019
Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult population. Primary EBV infection usually occurs during childhood and is generally asymptomatic, though the virus can cause infectious mononucleosis in 35–50% of the ...
G. Andrei, E. Trompet, R. Snoeck
semanticscholar   +1 more source

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T‐Cell Lymphoma

American Journal of Hematology, EarlyView.
ABSTRACT Nodal follicular helper T‐cell (TFH) lymphoma of the angioimmunoblastic (AITL) subtype has a dismal prognosis. Using whole‐exome sequencing (n = 124), transcriptomic (n = 78), and methylation (n = 40) analysis, we identified recurrent mutations in known epigenetic drivers (TET2, DNMT3A, IDH2R172) and novel ones (TET3, KMT2D).
Alyssa Bouska, Weiwei Zhang, Sunandini Sharma, Harald Holte, Rauf A. Shah, Waseem G. Lone, Mahfuza Afroz Soma, Ruimeng Yang, Xuxiang Liu, Syed Mehmood, Ravneet Singh Chawla, Luca Vincenzo Cappelli, Danilo Fiore, Qiang Gong, Tayla B. Heavican‐Foral, Jeffrey J. Cannatella, Catalina Amador, Aiza Arif, Lynette M. Smith, Soon Thye Lim, Choon Kiat Ong, Andrew L. Feldman, Ming‐Qing Du, Anamarija M. Perry, Laurence de Leval, Timothy C. Greiner, Kai Fu, Gunhild Trøen, Daniel Vodák, Sigve Nakken, Jan Delabie, David Weinstock, Stefano Pileri, Antonella Laginestra, KyeongJin Kim, Utpal Pajvani, Julie M. Vose, Dennis D. Weisenburger, Steven M. Horwitz, Sandeep Dave, Joseph Khoury, Giorgio Inghirami, Wing C. Chan, Javeed Iqbal   +43 more
wiley   +1 more source