Clinical‐Stage Nanatinostat Triggers Productive Epstein‐Barr Virus Lytic Replication
ABSTRACT A phase 1b/2 study of the all‐oral “kick‐and‐kill” combo nanatinostat + valganciclovir (nana‐val) showed a ~40% overall response rate in patients with relapsed/refractory Epstein‐Barr virus (EBV)‐associated lymphomas. Despite the promising results in these difficult‐to‐treat cancers, there is little known about the effects of nanatinostat on ...
Ibukun A. Akinyemi +6 more
wiley +1 more source
A Snapshot of the UK Blood Donor Plasma Virome: A Retrospective Cross‐Sectional Cohort Study
ABSTRACT Estimates of population prevalence and genetic diversity of bloodborne viruses in healthy humans are essential to support population‐scale monitoring for transfusion transmission risk. In the UK and globally, blood donations are routinely screened for a limited number of high‐consequence pathogens, but the full composition of the plasma virome
Kai Kean +12 more
wiley +1 more source
No substantial causal effect of genetic liability to viral infections on subacute thyroiditis: A large-scale Mendelian randomization analysis. [PDF]
Zeng S, Cheng W.
europepmc +1 more source
ABSTRACT Antibodies to Epstein‐Barr virus (EBV) proteins can predict nasopharyngeal carcinoma (NPC) risk. We previously defined a prototype EBNA1 protein panel and multiplex immunoblot assay that distinguishes NPC risk several years pre‐diagnosis.
Benjamin E. Warner +7 more
wiley +1 more source
Epstein-Barr Virus in Brain Cancer-Friend or Foe? [PDF]
Brzozowski M +3 more
europepmc +1 more source
ABSTRACT The infection theory of dementia states that viral infections and chronic inflammation play a role in its pathogenesis. We aimed to test whether testing positive for inherited chromosomally‐integrated human herpesvirus 6 (iciHHV‐6) is associated with an increased dementia incidence, inflammation, and other dementia risk factors. We included n =
Zhong Qiya +5 more
wiley +1 more source
Association Between Chikungunya Infection and Rheumatoid Arthritis in Taiwan—A Cross‐Sectional Study
ABSTRACT Objectives Chikungunya virus (CHIKV) infection might cause chronic chikungunya arthritis resembling rheumatoid arthritis (RA). The purpose of this study is to investigate the potential role of this virus in the pathogenesis of RA in Taiwan, a non‐endemic area. Methods This cross‐sectional study enrolled 98 RA patients and 200 healthy controls.
Chang‐Yi Yen +12 more
wiley +1 more source
A Post-Pandemic Surge: Sustained High Prevalence and Epidemiological Shift in Pediatric Epstein-Barr Virus Infection. [PDF]
Li H, Tao R, Li W, Shang S.
europepmc +1 more source
Infection control in the brain and the eye
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester +2 more
wiley +1 more source
Dizziness after mononucleosis: Recognizing rare neurologic complications of Epstein-Barr virus. [PDF]
Marinho B.
europepmc +1 more source

