Results 91 to 100 of about 71,544 (304)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Equivalence and bifurcations of finite order stochastic processes [PDF]

, 2005
This article presents an equivalence notion of finite order stochastic processes. Local dependence measures are defined in terms of ratios of joint and marginal probability densities.
Wagener, Florian O. O., Diks, Cees, Wagener, Florian, Cees G. H. Diks, Florian O. O. Wagener   +4 more
core   +1 more source

The Effect of Changing Exhaust Nozzle Geometry on Temperature Distribution and Emissions of Methane Diffusion Flame Under Air/Fuel Swirl Flows

Energies
The performance of diffusion flame (DF) burners strongly depends on how effectively combustion gases mix and retain heat, yet the influence of exhaust nozzle geometry on these processes remains insufficiently characterized.
Salim Al Hamdani, Abdullah Al-Janabi, Sulaiman Al-Obidani, Ali Al-Hinaai, Ahmed Elwardany   +4 more
doaj   +1 more source

Effect of the Fuel Equivalence Ratio on the Mechanisms of Thiophene Oxidation in Water Vapor at Increased Density of the Reagents. [PDF]

ACS Omega, 2021
Fedyaeva ON, Shishkin AV, Vostrikov AA.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Detailed measurements of equivalence ratio modulations in premixed flames using laser Rayleigh scattering and absorption spectroscopy

, 2010
International audienceEquivalence ratio non-uniformities may give rise to some of the instabilities observed in modern lean premixed combustion systems.
Schwarz, Heiner, Laurent Zimmer, Daniel Durox, Candel, Sébastien, Heiner Schwarz, Zimmer, Laurent, Durox, Daniel, Sébastien Candel   +7 more
core   +1 more source

Effect of pointed and diffused air injection on premixed flame confined in a Rijke tube

Cogent Engineering, 2016
The coupling between pressure fluctuations and unsteady heat release in a combustion systems results in acoustic oscillations inside the combustion system.
Nilaj N. Deshmukh, S.D. Sharma
doaj   +1 more source

Structure and Laminar Flame Speed of an Ammonia/Methane/Air Premixed Flame under Varying Pressure and Equivalence Ratio. [PDF]

Energy Fuels, 2021
Rocha RC, Zhong S, Xu L, Bai XS, Costa M, Cai X, Kim H, Brackmann C, Li Z, Aldén M.   +9 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Analysis of turbulent flame propagation in equivalence ratio-stratified flow

, 2015
Effects of equivalence ratio stratification on turbulent combustion processes are investigated using Direct Numerical Simulation. The simulation results are analysed in terms of flame surface area and the burning intensity.
Richardson, E.S., Chen, J.H.
core