Results 91 to 100 of about 352,444 (305)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Conserved scalar and progress variable for internal combustion engine simulation with chemical kinetics

open access: yesNihon Kikai Gakkai ronbunshu, 2018
The conserved scalar and progress variable have been modified and proposed for spray and engine combustion simulation with chemical kinetics. The global equivalence ratio (GER) and progress equivalence ratio (PER) were proposed as the conserved scalar ...
Tsukasa HORI
doaj   +1 more source

Distributional equivalence and subcompositional coherence in the analysis of contingency tables, ratio-scale measurements and compositional data [PDF]

open access: yes
We consider two fundamental properties in the analysis of two-way tables of positive data: the principle of distributional equivalence, one of the cornerstones of correspondence analysis of contingency tables, and the principle of subcompositional ...
Michael Greenacre, Paul Lewi
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Analysis of Equivalence Ratio in an Oxygen Acetylene Mixture

open access: yesINCAS Bulletin, 2019
The paper presents an exclusive approach to analyze the oxygen and acetylene mixture in a Pulse Detonation Engine setup at PEC. The experiment was carried out by varying the amount of mass flow of acetylene and oxygen into the tube at different pressures
SHIVAM   +4 more
doaj   +1 more source

A study of hydrogen diffusion flames using PDF turbulence model [PDF]

open access: yes
The application of probability density function (pdf) turbulence models is addressed. For the purpose of accurate prediction of turbulent combustion, an algorithm that combines a conventional computational fluid dynamic (CFD) flow solver with the Monte ...
Hsu, Andrew T.
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Effect of pointed and diffused air injection on premixed flame confined in a Rijke tube

open access: yesCogent Engineering, 2016
The coupling between pressure fluctuations and unsteady heat release in a combustion systems results in acoustic oscillations inside the combustion system.
Nilaj N. Deshmukh, S.D. Sharma
doaj   +1 more source

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