Results 71 to 80 of about 352,444 (305)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

NO formation/reduction mechanisms of ammonia/air premixed flames at various equivalence ratios and pressures

Mechanical Engineering Journal, 2015
Ammonia is a carbon-free fuel and its application to internal combustion engines is expected. However, few studies on ammonia flames, especially at high pressures, have been carried out because ammonia has not been considered to be a fuel owing to its ...
Akihiro HAYAKAWA, Takashi GOTO, Rentaro MIMOTO, Taku KUDO, Hideaki KOBAYASHI   +4 more
doaj   +1 more source

Derivation of Feynman Rules for Higher Order Poles Using Cross-ratio Identities in CHY Construction

, 2017
In order to generalize the integration rules to general CHY integrands which include higher order poles, algorithms are proposed in two directions. One is to conjecture new rules, and the other is to use the cross-ratio identity method.
Feng, Bo, Rao, Junjie, Zhou, Kang
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Study on Explosion Mechanism of Dimethyl Ether/H₂-Blended Gas Based on Chemical Kinetics Method

Fire
In order to reveal the deflagration mechanism of DME/H2-blended gasses, the micro-mechanism was studied based on the constructed UC San Diego 2016 pyrolysis oxidation mechanism model.
Yong Zhou, Yang Kong, Qi Zhang, Qi Huang, Zhikai Wei, Huaheng Lu   +5 more
doaj   +1 more source

A Nominal Theory of the Nominal Rate of Interest and the Price Level: Some Empirical Evidence [PDF]

This paper aims to investigate the impact of the bond/money ratio on the nominal interest rate. The econometric model chosen fits a dynamic panel data for Canada, Japan and US over the period 1980-2006.
Geraldo Silva Souza, Tito B.S. Moreira
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Numerical and Experimental Investigation of Equivalence Ratio (ER) and Feedstock Particle Size on Birchwood Gasification

Energies, 2017
This paper discusses the characteristics of Birchwood gasification using the simulated results of a Computational Fluid Dynamics (CFD) model. The CFD model is developed and validated with the experimental results obtained with the fixed bed downdraft ...
Rukshan Jayathilake, Souman Rudra
doaj   +1 more source

Effects of equivalence ratio and dwell time on exhaust emissions from an experimental premixing prevaporizing burner [PDF]

A flame-tube study was performed to determine the effects of equivalence ratio and residence time on exhaust emissions with premixed, prevaporized propane fuel.
Anderson, D.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source