Results 71 to 80 of about 350,384 (304)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Numerical and Experimental Investigation of Equivalence Ratio (ER) and Feedstock Particle Size on Birchwood Gasification

Energies, 2017
This paper discusses the characteristics of Birchwood gasification using the simulated results of a Computational Fluid Dynamics (CFD) model. The CFD model is developed and validated with the experimental results obtained with the fixed bed downdraft ...
Rukshan Jayathilake, Souman Rudra
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Effect of primary-zone equivalence ratio on pollutant formation [PDF]

Test were conducted to determine the effect of primary-zone equivalence ratio on the formation of smoke and other gaseous pollutants in an experimental can combustor. Several fuel injection techniques were examined at primary-zone equivalence ratios from
Claus, R. W.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Nominal Theory of the Nominal Rate of Interest and the Price Level: Some Empirical Evidence [PDF]

This paper aims to investigate the impact of the bond/money ratio on the nominal interest rate. The econometric model chosen fits a dynamic panel data for Canada, Japan and US over the period 1980-2006.
Geraldo Silva Souza, Tito B.S. Moreira
core  

An Equivalence Test between Mantel-Haenszel Rate Ratio and Standardized Mortality Ratio

Journal of Epidemiology, 1994
In the analysis of stratified person-time follow-up data, the multiplicative incidence rate model requires the rate ratio homogeneity across strata. This homogeneity assumption is statistically convenient but biologically stringent. When we do not have any strong biological models on incidence rate ratio homogeneity, we cannot justify using the ...
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Flame structure simulation in a methane/air coflow partially premixed burner

Revista Facultad de Ingeniería Universidad de Antioquia, 2014
The effect of the equivalence ratio on the partially premixed methane / air laminar flame structure, in a coflow atmospheric burner was simulated. Three equivalence ratios were studied (Φ=1.6, Φ=2.0, Φ=3.5) keeping constant the released energy.
Julio Rendón, Francisco Cadavid, Andrés Amell   +2 more
doaj   +1 more source

Derivation of Feynman Rules for Higher Order Poles Using Cross-ratio Identities in CHY Construction

, 2017
In order to generalize the integration rules to general CHY integrands which include higher order poles, algorithms are proposed in two directions. One is to conjecture new rules, and the other is to use the cross-ratio identity method.
Feng, Bo, Rao, Junjie, Zhou, Kang
core   +1 more source