Results 111 to 120 of about 29,801 (212)

Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, EarlyView.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

Centering geospatial data uncertainty and the potential for injustice in pastoralist rangeland conservation prioritization

Conservation Biology, EarlyView.
Abstract Procedural, distributional, recognitional, and epistemic justice aspects of conservation interventions are well documented in contexts where pastoralism is a key livelihood and way of life. Geospatial analyses and representations of wildlife conservation and restoration that are increasingly applied in pastoralist rangeland socioecological ...
Ryan R. Unks
wiley   +1 more source

17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression

Journal of Experimental & Clinical Cancer Research, 2018
Background In non-small cell lung cancer (NSCLC), estrogen (E2) significantly promotes NSCLC cell growth via estrogen receptor beta (ERβ). Discovery and elucidation of the mechanism underlying estrogen-promoted NSCLC progression is critical for effective
Quanfu Huang, Zheng Zhang, Yongde Liao, Changyu Liu, Sheng Fan, Xiao Wei, Bo Ai, Jing Xiong   +7 more
doaj   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2001
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co-repressors,
Indarto, Dono, Izawa, Masao
core  

Descrição atualizada da paralisia cerebral

Developmental Medicine &Child Neurology, EarlyView.
Resumo A paralisia cerebral (PC) é um termo descritivo amplamente utilizado para um espectro de deficiências motoras causadas por lesão ou malformação cerebral não progressiva ocorrida durante as fases iniciais do desenvolvimento. Avanços recentes nas áreas da genética, de pesquisa em inflamação e em neurofisiologia têm refinado a compreensão ...
Bernard Dan, Peter Rosenbaum, Lucinda Carr, Martin Gough, John Coughlan, Nonyelum Nweke   +5 more
wiley   +1 more source

Proteomic Profiling of Plasma to Uncover Novel Intervention Targets and Prognostic Biomarkers for Chronic Liver Diseases

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li, Jing Sun, Jianhui Zhao, Fangyuan Jiang, Meng Zhang, Hao Wu, Shuai Yuan, Xue Li, Juan Lu, Christos S. Mantzoros   +9 more
wiley   +1 more source

Spanish stock returns, growth, and inflation, 1900–2020

The Economic History Review, EarlyView.
Abstract This paper studies equity returns in the Madrid Stock Exchange and their connections with the macroeconomy from the emergence of a stock market around 1900 to its ‘big bang’ at the turn of the twenty‐first century. Using high‐quality data from primary sources and the methodology of the modern IBEX35 (published since 1987), we constructed an ...
Stefano Battilossi, Stefan O. Houpt, Miguel Artola Blanco   +2 more
wiley   +1 more source

A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals

Heliyon
In this study we present an inducible biosensor model for the Estrogen Receptor Beta (ERβ), GFP-ERβ:PRL-HeLa, a single-cell-based high throughput (HT) in vitro assay that allows direct visualization and measurement of GFP-tagged ERβ binding to ER ...
Derek A. Abbott, Maureen G. Mancini, Michael J. Bolt, Adam T. Szafran, Kaley A. Neugebauer, Fabio Stossi, Daniel A. Gorelick, Michael A. Mancini   +7 more
doaj   +1 more source

Perinatal testosterone exposure potentiates vascular dysfunction by ERβ suppression in endothelial progenitor cells.

PLoS ONE, 2017
Recent clinical cohort study shows that testosterone therapy increases cardiovascular diseases in men with low testosterone levels, excessive circulating androgen levels may play a detrimental role in the vascular system, while the potential mechanism ...
Weiguo Xie, Mingming Ren, Ling Li, Yin Zhu, Zhigang Chu, Zhigang Zhu, Qiongfang Ruan, Wenting Lou, Haimou Zhang, Zhen Han, Xiaodong Huang, Wei Xiang, Tao Wang, Paul Yao   +13 more
doaj   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source