Results 1 to 10 of about 3,252 (178)

ER-phagy restrains inflammatory responses through its receptor UBAC2 [PDF]

The EMBO Journal
ER-phagy, a selective form of autophagic degradation of endoplasmic reticulum (ER) fragments, plays an essential role in governing ER homeostasis. Dysregulation of ER-phagy is associated with the unfolded protein response (UPR), which is a major clue for
Xing He, Haowei He, Zitong Hou, Zheyu Wang, Qinglin Shi, Tao Zhou, Yaoxing Wu, Yunfei Qin, Jun Wang, Zhe Cai, Jun Cui, Shouheng Jin   +11 more
doaj   +4 more sources

Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells [PDF]

Molecular Brain, 2021
Palmitate is a saturated fatty acid that is well known to induce endoplasmic reticulum (ER) stress and autophagy. A high-fat diet increases the palmitate level in the hypothalamus, the main region of the brain regulating energy metabolism. Interestingly,
Yun Lim, Seolsong Kim, Eun-Kyoung Kim
doaj   +2 more sources

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways [PDF]

Nature Communications, 2023
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes.
Rayene Berkane, Hung Ho-Xuan, Marius Glogger, Pablo Sanz-Martinez, Lorène Brunello, Tristan Glaesner, Santosh Kumar Kuncha, Katharina Holzhüter, Sara Cano-Franco, Viviana Buonomo, Paloma Cabrerizo-Poveda, Ashwin Balakrishnan, Georg Tascher, Koraljka Husnjak, Thomas Juretschke, Mohit Misra, Alexis González, Volker Dötsch, Paolo Grumati, Mike Heilemann, Alexandra Stolz   +20 more
doaj   +2 more sources

RETREG1/FAM134B-mediated micro-ER-phagy in the retrovirus–SERINC5 arms race [PDF]

Autophagy Reports
Reticulophagy regulator 1 (RETREG1)/Family with sequence similarity 134 member B (FAM134B) is a selective endoplasmic reticulum (ER)-phagy receptor that mediates starvation-induced macro-ER-phagy, but whether it participates in other pathways mediating ...
Jim Maurice Camilleri, Iqbal Ahmad, Jing Zhang, Sunan Li, Yong-Hui Zheng   +4 more
doaj   +2 more sources

Plant rhabdovirus glycoprotein activates unfolded protein response-mediated antiviral ER-phagy in insect vectors. [PDF]

PLoS Pathogens
Although viral infection-induced endoplasmic reticulum autophagy (ER-phagy) is well characterized in mammalian systems, the mechanisms underlying arbovirus-triggered ER-phagy in insect vectors remain poorly understood.
Siyu Chen, Yu Cheng, Yupeng Tang, Jian Zhang, You Li, Dongsheng Jia, Hongyan Chen, Taiyun Wei   +7 more
doaj   +2 more sources

Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum. [PDF]

Nature, 2023
The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy1. ER-phagy receptors have a central role in this process2, but the regulatory mechanism remains largely unknown.
González A, Covarrubias-Pinto A, Bhaskara RM, Glogger M, Kuncha SK, Xavier A, Seemann E, Misra M, Hoffmann ME, Bräuning B, Balakrishnan A, Qualmann B, Dötsch V, Schulman BA, Kessels MM, Hübner CA, Heilemann M, Hummer G, Dikić I.   +18 more
europepmc   +3 more sources

An Essential Role for Calnexin in ER-Phagy and the Unfolded Protein Response [PDF]

Cells
ER-phagy is a specialized form of autophagy, defined by the lysosomal degradation of ER subdomains. ER-phagy has been implicated in relieving the ER from misfolded proteins during ER stress upon activation of the unfolded protein response (UPR). Here, we
Daniel Wolf, Chiara Röder, Michael Sendtner, Patrick Lüningschrör   +3 more
doaj   +2 more sources

The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection [PDF]

Nature Communications
Macroautophagy/autophagy is a key catabolic-recycling pathway that can selectively target damaged organelles or invading pathogens for degradation. The selective autophagic degradation of the endoplasmic reticulum (hereafter referred to as ER-phagy) is a
Damián Gatica, Reham M. Alsaadi, Rayan El Hamra, Boran Li, Rudolf Mueller, Makoto Miyazaki, Qiming Sun, Subash Sad, Ryan C. Russell   +8 more
doaj   +2 more sources

Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress [PDF]

Cell Death and Disease, 2022
In the tumor microenvironment, cancer cells experience hypoxia resulting in the accumulation of misfolded/unfolded proteins largely in the endoplasmic reticulum (ER).
Sandhya Chipurupalli, Raja Ganesan, Giulia Martini, Luigi Mele, Alessio Reggio, Marianna Esposito, Elango Kannan, Vigneshwaran Namasivayam, Paolo Grumati, Vincenzo Desiderio, Nirmal Robinson   +10 more
doaj   +2 more sources

Generating ER-TRG and CA-ER-TRG Knock-in Mice and Quantitative in vivo Imaging of ER-phagy [PDF]

Bio-Protocol
ER-phagy, a selective autophagy process crucial for maintaining cellular homeostasis by targeting the endoplasmic reticulum (ER), has been challenging to study in vivo due to the lack of suitable spatiotemporal quantification tools. Existing methods like
Mengyuan Zhang, Yu Zhang, Yongjuan Sang, Qiming Sun   +3 more
doaj   +2 more sources