Results 91 to 100 of about 3,252 (178)

REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy

Advanced Science, Volume 13, Issue 2, 9 January 2026.
REEP1 contributes to endoplasmic reticulum (ER) shaping. Variants either cause cortical motoneuron degeneration and hereditary spastic paraplegia (HSP) or spinal motoneuron degeneration and distal hereditary motor neuropathy (dHMN). Knockout causes less complex ER structures and cortical motoneuron loss.
Andrea Bock, Mona Schurig, Miles Willoughby, Andrea Mirecki, Eric Seemann, Kateryna Lohachova, Istvan Katona, Sonnhild Mittag, Lutz Liebmann, Patricia Franzka, Mehdi Heidari Horestani, Mukhran Khundadze, Thorsten Mosler, Timothy Louie, Marianne de Visser, Marian A. J. Weterman, Michael Kiehntopf, Christian Beetz, Sandor Nietzsche, Otmar Huber, Joachim Weis, Michael M. Kessels, Ramachandra M. Bhaskara, Britta Qualmann, Ivan Đikić, Christian A. Hübner   +25 more
wiley   +1 more source

The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes

Nature Communications, 2023
Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms for ER proteins and aggregates, respectively; however, the crosstalk between these two pathways under physiological settings remains unexplored.
Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H. Hunter, Deyu Fang, Shengyi Sun, Magdalena I. Ivanova, Yi Lin, Ling Qi   +15 more
doaj   +1 more source

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]

, 2019
The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine, Bock-Bierbaum, Tobias, Danieli, Alberto, Daumke, Oliver, Shi, Xiaoshan [u.v.m.], Su, Ming-Yuan, Sztacho, Martin, Trapannone, Riccardo, Turco, Eleonora, Witt, Marie   +9 more
core   +1 more source

MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B [PDF]

, 2020
Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification ofER-phagy receptors has shed light on the molecular mechanisms underlining ...
Ballabio A, Bonn F, Cesana M, Cinque L, Conte I, De Cegli R, De Leonibus C, Di Malta C, Dikic I, Grumati P, Huebner AK, Hübner CA, Iavazzo M, Intartaglia D, Krahmer N, Lanzara C, Maddaluno M, Mann M, Polishchuk E, Sacco F, Salierno FG, Settembre C., Svelto M, Wanderlingh LG   +23 more
core   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
MAMs are involved in the occurrence and development of epilepsy through calcium ion homeostasis imbalance, mitochondrial dysfunction, endoplasmic reticulum stress and inflammation, abnormal lipid metabolism, as well as autophagy and mitochondrial autophagy. This picture was drawn using Figdraw.
Huaiyu Sun, Xuewei Li, Weixuan Zhao, Wuqiong Zhang, Hongmei Meng   +4 more
wiley   +1 more source

Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor

Scientific Reports, 2021
Selective autophagy requires the autophagy receptor specifically localizing to the target for degradation. In the budding yeast, Atg39 and Atg40 function as an autophagy receptor for the endoplasmic reticulum (ER)-selective autophagy, referred to as ER ...
Tomoaki Mizuno, Kenji Irie
doaj   +1 more source

O‐GlcNAc Transferase Promotes Metabolic Dysfunction‐Associated Steatotic Liver Disease‐Related Hepatocellular Carcinoma by Facilitating the Degradation of PTEN

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Lipid‐rich and hypoxia tumor microenvironment elevates O‐GlcNAc transferase (OGT) expression, catalyzing O‐GlcNAcylation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) which in turn negatively regulates PTEN to promotes the growth of hepatocellular carcinoma (HCC).
Haoran Liu, Suming Pu, Wenxin Zhu, Jing Huang, Jianming Li   +4 more
wiley   +1 more source

ER-Phagie und Neurodegeneration

BIOspektrum
Abstract Autophagy is a process to target substrates for lysosomal degradation, which starts with the enclosure of the substrate by the LC3-labelled isolation membrane and the subsequent fusion with lysosomes. Selectivity of this process can be achieved via autophagy receptors. In recent years, several receptors which target ER subdomains for
Christian A. Hübner, Ivan Ðikić
openaire   +1 more source

Endoplasmic Reticulum Area Expands Upon Onset of the Unfolded Protein Response [PDF]

, 2016
The endoplasmic reticulum (ER) is a dynamic organelle responsible for essential cell functions such as protein folding, calcium storage, and lipid synthesis. It also directly interacts with and regulates other organelles in the cell, such as endosomes or
Cook, Katelyn Camille
core   +2 more sources

Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: Catabolic adaptation, stress responses, and autophagic processes [PDF]

, 2012
Background: Pichia pastoris is an established eukaryotic host for the production of recombinant proteins. Most often, protein production is under the control of the strong methanol-inducible aox1 promoter.
Adnan, Ahmad, Gurramkonda, Chandrasekhar, Khanna, Navin, Lünsdorf, Heinrich, Nimtz, Manfred, Rinas, Ursula, Vanz, Ana Leticia   +6 more
core   +4 more sources