Results 101 to 110 of about 3,252 (178)

Autophagy in PE: Dispute, Role and Potential Target

Cell Proliferation, Volume 58, Issue 12, December 2025.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu, Qi Wang, Fang Wang, Li Kang, Huijing Ma, Mengnan Li, Zhuanghui Hao, Zhengrui Li, Ji'an Liu, Xufeng Huang, Hengrui Liu, Shouxin Wei, Hailan Yang   +12 more
wiley   +1 more source

The unfolded protein response in immunity and inflammation. [PDF]

, 2016
The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces.
a Bertolotti, A Dela Pena, A Kaser, A Kaser, A Khaminets, A Murthy, A Shkoda, A Tsuru, AA Gupte, AB Tam, AD Garg, AG Lerner, AH Lee, AH Lee, AL Shaffer, AM Reimold, AM Reimold, Arthur Kaser, AV Korennykh, AW Paton, B Kharabi Masouleh, B Song, BG Wouters, BK Jha, BM Gardner, BP Tu, C Hetz, C Hetz, C Nathan, C Zhao, CA Turner Jr, CC Hu, CE Richardson, CK Heazlewood, CM Oslowski, CS Sevier, CW Woo, CW Woo, D Kamimura, D Pincus, D Ron, D Scheuner, D Walsh, DH Suh, DJ Todd, DL Herber, DP Granados, DP McGovern, DT Rutkowski, DT Rutkowski, E Pikarsky, E Tashiro, E van Anken, EF van't Wout, F Chiti, F Martinon, F Osorio, F Urano, F Zhao, G Auf, G Kroemer, G Marino, G Wang, GP Meares, GT Furuta, H Kaneto, H Kono, H Malhi, H Pillich, H Saibil, H Yamazaki, H Yoshida, HC Clevers, HJ Clarke, HJ Kim, HP Harding, HP Harding, HP Harding, I Hassan, I Papandreou, J Celli, J Deng, J Hampe, J Han, J Hollien, J Van Limbergen, J Wang, J Wu, JC Barrett, JD Blais, JD Malhotra, JD Malhotra, JH Connor, JH Lin, JJ Deuring, Joep Grootjans, JP Upton, JR Cubillos-Ruiz, JR Hassler, K Brandl, K Hino, K Kiefer, K Zhang, K Zhang, K Zhang, KD Tardif, KG Lassen, KM Rouschop, KM Vattem, L Qin, L Senovilla, L Yang, L Zitvogel, LR Palam, LS Hart, M Koritzinsky, M Lu, M Maurel, M Mulvey, M Schroder, M Wang, M Wang, MF Moffatt, MH Smith, MM Ali, N Claudio, N Hosogai, N Mimura, NN Iwakoshi, NN Iwakoshi, NR Mahadevan, NR Mahadevan, NR Mahadevan, NS Chitnis, P Hu, P Hu, Q Qiu, R Asada, R Brunsing, R Eferl, R Ghosh, R Ravindran, R Sciammas, R Volmer, R Zhou, Randal J. Kaufman, RD Eri, RE Hammer, Richard S. Blumberg, RJ Jackson, S Benhamron, S Bernales, S Bhattacharyya, S Bogaert, S Fu, S Kim, S Li, S Milic, S Nakajima, S Oyadomari, S Tsunoda, SA Oakes, SB Qian, SC Eckard, SE Bettigole, SE Bettigole, SJ Marciniak, SS Cao, SS Cao, T Iwawaki, T Mujtaba, TE Adolph, U Ozcan, U Ozcan, V Kumar, VT Chu, W B'Chir, W Tirasophon, W Zheng, X Chen, XM Zhu, Y Iwasaki, Y Kouroku, Y Li, Y Luo, Y Qiu, Y Wang, Y Zheng, Z Talloczy, Z Wenfeng   +189 more
core   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

ER homeostasis and autophagy [PDF]

, 2017
The endoplasmic reticulum (ER) is a key site for lipid biosynthesis and folding of nascent transmembrane and secretory proteins. These processes are maintained by careful homeostatic control of the environment within the ER lumen.
Smith, Matthew, Wilkinson, Simon
core   +1 more source

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, Volume 292, Issue 22, Page 5899-5920, November 2025.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis [PDF]

, 2017
published_or_final_versio
Feng, Y, LI, S, Tan, HYH, Wang, N
core   +1 more source

New Mechanisms for Regulation of Intracellular Collagen Degradation in Fibrotic Lesions of Periodontal Tissues

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Drug‐induced gingival overgrowth involves dysregulation of intracellular collagen degradation. The mechanisms that are involved in the regulation of lysosomal collagenolytic activity are poorly understood. Here, we focus on how cathepsins, Rabs, and V‐ATPases regulate intracellular collagen degradation and, in particular, the vesicular trafficking and ...
Wing Hei Wong, Ralph A. Zirngibl, Morris F. Manolson, Christopher A. McCulloch   +3 more
wiley   +1 more source

Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.
ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv, Chen Ye, Zixi Li, Jiajia Ye, Huanhuan Cao, Chun Zhang, Huajun Jiang, Yumei Wang   +7 more
wiley   +1 more source

UFMylation System: Biological Functions, Molecular Mechanisms, Diseases, and Drug Discovery

MedComm, Volume 6, Issue 10, October 2025.
UFMylation, a novel ubiquitin‐like modification, plays an essential role in various cellular processes, such as the immune response, DNA damage repair, unfolded protein response (UPR), autophagy, endoplasmic reticulum (ER)‐phagy, stem cell self‐renewal, apoptosis, and metastasis.
Huiyan Li, Fei Meng, Junjie Liang, Yijie Wang, Changliang Shan, Yan Chen   +5 more
wiley   +1 more source

Mitochondria Autophagy in Yeast [PDF]

, 2011
The mitochondrion is an organelle that carries out a number of important metabolic processes such as fatty acid oxidation, the citric acid cycle, and oxidative phosphorylation.
Kanki, Tomotake, Klionsky, Daniel J., Okamoto, Koji   +2 more
core   +2 more sources