Results 161 to 170 of about 3,252 (178)

SGLT2 inhibitor promotes mitochondrial dysfunction and ER-phagy in colorectal cancer cells. [PDF]

Cell Mol Biol Lett
Anastasio C, Donisi I, Del Vecchio V, Colloca A, Mele L, Sardu C, Marfella R, Balestrieri ML, D'Onofrio N.   +8 more
europepmc   +1 more source

Qingre Huoxue decoction attenuates myocardial ischemia‒reperfusion injury by regulating the autophagy‒endoplasmic reticulum stress axis via FAM134B-mediated ER-phagy. [PDF]

Front Pharmacol
Li R, Zhang J, Ji S, Fang J, Ji X, Zeng Y, Liu N, Wu W, Liu S.   +8 more
europepmc   +1 more source

Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia. [PDF]

Cell Mol Life Sci
Wei XH, Liao LY, Yin YX, Xu Q, Xie SS, Liu M, Gao LB, Chen HQ, Zhou R.   +8 more
europepmc   +1 more source

PRRSV non-structural protein 5 inhibits antiviral innate immunity by degrading multiple proteins of RLR signaling pathway through FAM134B-mediated ER-phagy. [PDF]

J Virol
Wang J, Sun H, Li R, Xu S, Guo J, Xing G, Jia B, Qiao S, Chen X-x, Zhang G.   +9 more
europepmc   +1 more source

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Regulatory events controlling ER-phagy

Current Opinion in Cell Biology, 2022
Autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is responsible for the degradation of ER portions by lysosomes. ER-phagy is induced in both physiological and stress conditions to maintain ER homeostasis and protein quality control. ER-phagy receptors and their interactors are key regulators of this process.
Francescopaolo, Iavarone, Giorgia, Di Lorenzo, Carmine, Settembre   +2 more
openaire   +4 more sources

Endoplasmic Reticulum (ER) and ER-Phagy

2021
The endoplasmic reticulum (ER) is a biosynthetic organelle in eukaryotic cells. Its capacity to produce proteins, lipids and oligosaccharides responds to physiologic and pathologic demand. The transcriptional and translational unfolded protein response (UPR) programs increase ER size and activity.
Marisa, Loi, Alessandro, Marazza, Maurizio, Molinari   +2 more
openaire   +2 more sources

USP20 deubiquitinates and stabilizes the ER-phagy receptor FAM134B to drive ER-phagy

2023
AbstractThe endoplasmic reticulum (ER) serves as a hub for various essential cellular processes, and maintaining ER homeostasis is essential for cell function. ER-phagy is a selective process that removes impaired ER subdomains through autophagosomes and lysosomal degradation.
Zhang Man, Zhangshun Wang, Qing Zhao, Qian Yang, Cuiwei Yang, Yanfen Liu   +5 more
openaire   +1 more source

Analysis of ER-Phagy in Cancer Drug Resistance

2022
The ability of the cancer cells to survive hostile environment depends on their cellular stress response mechanisms. These mechanisms also help them to develop resistance to chemotherapies. Autophagy and more specifically organelle specific autophagy is one such adaptive mechanism that promotes drug resistance in cancer cells.
Sandhya, Chipurupalli, Vincenzo, Desiderio, Nirmal, Robinson   +2 more
openaire   +3 more sources

Excessive ER-phagy contributes to ochratoxin A-induced apoptosis

Food and Chemical Toxicology, 2023
The nephrotoxic secondary fungal metabolite ochratoxin A (OTA) is ubiquitously existed in foodstuffs and feeds. Although our earlier research provided preliminary evidence that endoplasmic reticulum (ER) was crucial in OTA-induced nephrotoxicity, more research is necessary to understand the fine-tune mechanisms involving ER stress (ERS), ER-phagy, and ...
Huiqiong Deng, Wenying Chen, Boyang Zhang, Yiwen Zhang, Lingyun Han, Qipeng Zhang, Song Yao, Hongwei Wang, Xiao Li Shen   +8 more
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Fine‐tuning ER‐phagy by post‐translational modifications

BioEssays, 2020
AbstractAutophagy functions in both selective and non‐selective ways to maintain cellular homeostasis. Endoplasmic reticulum autophagy (ER‐phagy) is a subclass of autophagy responsible for the degradation of the endoplasmic reticulum through selective encapsulation into autophagosomes. ER‐phagy occurs both under physiological conditions and in response
Mohamed A, Eldeeb, Cornelia E, Zorca, Mohamed A, Ragheb, Fatma B, Rashidi, Doaa S, Salah El-Din   +4 more
openaire   +2 more sources