Results 171 to 178 of about 3,252 (178)
Some of the next articles are maybe not open access.
Science, 2019
Cell Biology In eukaryotic cells, about one-third of all proteins are targeted to the endoplasmic reticulum (ER), which serves as a hub for secretory protein traffic and quality control. Cui et al. studied a protein known as Lst1 in yeast and SEC24C in mammalian cells that is involved in loading secretory cargo into vesicles that are delivered to the ...
openaire +1 more source
Cell Biology In eukaryotic cells, about one-third of all proteins are targeted to the endoplasmic reticulum (ER), which serves as a hub for secretory protein traffic and quality control. Cui et al. studied a protein known as Lst1 in yeast and SEC24C in mammalian cells that is involved in loading secretory cargo into vesicles that are delivered to the ...
openaire +1 more source
Methods for Monitoring ER-Phagy
The endoplasmic reticulum (ER) serves as a central hub for protein synthesis, folding, and lipid biosynthesis in eukaryotic cells. Maintaining ER homeostasis is essential for optimal cellular function, and one mechanism that has garnered attention is endoplasmic reticulum-specific autophagy, or ER-phagy.Di Monaco, Marisa +2 more
openaire +3 more sources
Science Signaling, 2018
Selective autophagy of the endoplasmic reticulum protects the secretory cells of the pancreas.
openaire +1 more source
Selective autophagy of the endoplasmic reticulum protects the secretory cells of the pancreas.
openaire +1 more source
Picky Eating at the ER-phagy Buffet
Trends in Biochemical Sciences, 2019The degradation of the endoplasmic reticulum (ER) by autophagy (ER-phagy) regulates proteostasis. Two studies (An et al., Mol. Cell, 2019; Chino et al., Mol. Cell, 2019) have uncovered a new ER-phagy molecule, TEX264, yielding insight into how ER is packaged for degradation, and have illuminated the extent of redundancy between different ER-phagy ...
openaire +2 more sources
ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum
Trends in Cell Biology, 2020The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and ion storage. To maintain its function, it is turned over constitutively, and even more actively under certain stress conditions.
Haruka Chino, Noboru Mizushima
openaire +2 more sources
ER-phagy in human atherosclerosis: an exploratory ultrastructural study
Ultrastructural Pathology, 2020Autophagy is a vacuolar self-digesting mechanism responsible for the removal of damaged organelles, indigestible aggregates, and nonfunctional long-lived proteins by lysosome. Autophagy is dynamically connected to the endoplasmic reticulum (ER) in several ways. It is capable to counteract the possible harmful effects linked to the impairment of protein
openaire +2 more sources
2020
Autophagy regulates the degradation of unnecessary or dysfunctional cellular components. This catabolic process requires the formation of a double-membrane vesicle, the autophagosome, that engulfs the cytosolic material and delivers it to the lysosome. Substrate specificity is achieved by autophagy receptors, which are characterized by the presence of ...
Hübner, C. +1 more
openaire +1 more source
Autophagy regulates the degradation of unnecessary or dysfunctional cellular components. This catabolic process requires the formation of a double-membrane vesicle, the autophagosome, that engulfs the cytosolic material and delivers it to the lysosome. Substrate specificity is achieved by autophagy receptors, which are characterized by the presence of ...
Hübner, C. +1 more
openaire +1 more source