Results 11 to 20 of about 3,252 (178)

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway [PDF]

Advanced Science
Progressive cardiac fibrosis post myocardial infarction (MI) drives pathological remodeling and heart failure, yet the role of endoplasmic reticulum‐selective autophagy (ER‐phagy) in this process remains unclear. Autocrine Motility Factor Receptor (AMFR)
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
doaj   +3 more sources

Sestrin2 drives ER-phagy in response to protein misfolding. [PDF]

Dev Cell
Protein biogenesis within the endoplasmic reticulum (ER) is crucial for organismal function. Errors during protein folding necessitate the removal of faulty products.
De Leonibus C, Maddaluno M, Ferriero R, Besio R, Cinque L, Lim PJ, Palma A, De Cegli R, Gagliotta S, Montefusco S, Iavazzo M, Rohrbach M, Giunta C, Polishchuk E, Medina DL, Di Bernardo D, Forlino A, Piccolo P, Settembre C.   +18 more
europepmc   +10 more sources

ER remodeling via ER-phagy [PDF]

Molecular Cell, 2022
The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER membrane is highly dynamic, which affects many cellular processes that take place within the ER.
Dikic, I., Gubas, A.
core   +6 more sources

ER-Phagy and Microbial Infection [PDF]

Frontiers in Cell and Developmental Biology, 2021
The endoplasmic reticulum (ER) is an essential organelle in cells that synthesizes, folds and modifies membrane and secretory proteins. It has a crucial role in cell survival and growth, thus requiring strict control of its quality and homeostasis ...
Jiahui Li, Jiahui Li, Enfeng Gao, Enfeng Gao, Chenguang Xu, Chenguang Xu, Hongna Wang, Hongna Wang, Hongna Wang, Yongjie Wei, Yongjie Wei, Yongjie Wei   +11 more
doaj   +3 more sources

Advances in ER-Phagy and Its Diseases Relevance [PDF]

Cells, 2021
As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis.
Lingang He, Xuehong Qian, Yixian Cui
doaj   +3 more sources

ER-Phagy: A New Regulator of ER Homeostasis [PDF]

Frontiers in Cell and Developmental Biology, 2021
The endoplasmic reticulum (ER) is one of the most important cellular organelles and is essential for cell homeostasis. Upon external stimulation, ER stress induces the unfolded protein response (UPR) and ER-associated degradation (ERAD) to maintain ER ...
Ming Yang, Ming Yang, Shilu Luo, Shilu Luo, Xi Wang, Chenrui Li, Jinfei Yang, Xuejing Zhu, Li Xiao, Lin Sun, Lin Sun   +10 more
doaj   +3 more sources

ER-phagy in the Occurrence and Development of Cancer

Biomedicines, 2022
As an organelle, the endoplasmic reticulum (ER) is closely related to protein synthesis and modification. When physiological or pathological stimuli induce disorders of ER function, misfolded proteins trigger ER-phagy, which is beneficial for restoring ...
Huimin Zhou, Kexin Wang, Mengyan Wang, Wenxia Zhao, Conghui Zhang, Meilian Cai, Yuhan Qiu, Tianshu Zhang, Rongguang Shao, Wuli Zhao   +9 more
doaj   +3 more sources

Cytosolic FKBPL and ER-resident CKAP4 co-regulates ER-phagy and protein secretion [PDF]

Nature Communications
Endoplasmic reticulum quality control is crucial for maintaining cellular homeostasis and adapting to stress conditions. Although several ER-phagy receptors have been identified, the collaboration between cytosolic and ER-resident factors in ER ...
Cathena Meiling Li, Jaemin Kang, Jongyeon Baek, Youbin Kim, Heemin Park, Yong-Keun Jung   +5 more
doaj   +2 more sources

Characterization of constitutive ER-phagy of excess membrane proteins.

PLoS Genetics, 2020
Thirty percent of all cellular proteins are inserted into the endoplasmic reticulum (ER), which spans throughout the cytoplasm. Two well-established stress-induced pathways ensure quality control (QC) at the ER: ER-phagy and ER-associated degradation ...
Zhanna Lipatova, Valeriya Gyurkovska, Sarah F Zhao, Nava Segev   +3 more
doaj   +4 more sources

ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress [PDF]

Nature Communications, 2019
The ER increases in size upon stress in response to the UPR and is remodelled after the stressor is removed by a process called recov-ER-phagy. Here, the authors show remodelling to pre-stress ER size occurs by micro-ER-phagy requiring ESCRT-III ...
Marisa Loi, Andrea Raimondi, Diego Morone, Maurizio Molinari   +3 more
doaj   +2 more sources