Inhibition of STING-mediated antiviral innate immunity activation by CD97 via modulation of ER-phagy [PDF]
Communications BiologyEndoplasmic reticulum (ER) autophagy (ER-phagy) is a vital homeostatic process triggered by multiple signals and plays a crucial role in regulating innate immunity and viral replication.
Huasong Chang +8 more
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ER stress and/or ER-phagy in drug resistance? Three coincidences are proof [PDF]
Cell Communication and SignalingCancer is influenced by the tumor microenvironment (TME), which includes factors such as pH, hypoxia, immune cells, and blood vessels. These factors affect cancer cell growth and behavior.
Sameer Kumar Panda +7 more
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DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis [PDF]
Cell Death and DiseaseAcute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated morbidity and mortality rates, emerging as a significant public health issue.
Haijiao Jin +15 more
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ER-Phagy and ER Stress Response (ERSR) in Plants [PDF]
Frontiers in Plant Science, 2019 The endoplasmic reticulum (ER) is the starting point for protein secretion and lipid biosynthesis in eukaryotes. ER homeostasis is precisely regulated by the unfolded protein response (UPR) to alleviate stress, involving both transcriptional and ...
Yonglun Zeng +4 more
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Placental RTN3L‐dependent ER‐Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress [PDF]
Advanced SciencePrenatal environmental stress damages fetal testicular development, leading to male infertility. However, the precise mechanisms underlying the impact of gestational environmental stress on fetal testicular development require further investigation. This
Ye‐Xin Luo +17 more
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Reticulon Homology Domain-Containing Proteins and ER-Phagy [PDF]
Frontiers in Cell and Developmental Biology, 2020 The endoplasmic reticulum (ER) is a dynamic membrane system comprising different and interconnected subdomains. The ER structure changes in response to different stress conditions through the activation of a selective autophagic pathway called ER-phagy ...
Manuela D’Eletto +2 more
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ADP ribosylation factor-like GTPase 6-interacting protein 5 (ARL6IP5): a prenylated Rab acceptor protein 1 (PRA1) family protein that shapes the ER membrane and regulates ER-phagy [PDF]
Autophagy ReportsThe prenylated Rab acceptor protein 1 (PRA1) domain is a conserved domain encompassing four transmembrane domains (TMDs). ARL6IP5 (ADP ribosylation factor-like GTPase 6-interacting protein 5) is a member of the PRA1 family and interacts with the ...
Yasunori Yamamoto, Toshiaki Sakisaka
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Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy. [PDF]
Proc Natl Acad Sci U S AIntrinsically disordered regions (IDRs) play a pivotal role in organellar remodeling. They transduce signals across membranes, scaffold signaling complexes, and mediate vesicular traffic.
Poveda-Cuevas SA +5 more
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AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity [PDF]
Nature CommunicationsFlaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, the role of ER autophagy (ER-phagy) in viral replication process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection
Linliang Zhang +13 more
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Animal Cells and Systems, 2023 Autophagy plays a critical role in regulating the quality and quantity of cellular compartments; however, the mechanisms governing endoplasmic reticulum (ER) autophagy (ER-phagy) are still largely undefined.
Joon Bum Kim +9 more
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