Results 31 to 40 of about 3,252 (178)

ER-Phagy, ER Homeostasis, and ER Quality Control:Implications for Disease [PDF]

, 2021
The lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, called ER-phagy or reticulophagy, occurs under normal as well as stress conditions. The recent discovery of multiple ER-phagy receptors has stimulated studies on the roles of
Brodsky, Jeffrey L, Ferro-Novick, Susan, Reggiori, Fulvio   +2 more
core   +1 more source

Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy [PDF]

, 2023
Membrane-shaping proteins characterized by reticulon homology domains play an important part in the dynamic remodelling of the endoplasmic reticulum (ER). An example of such a protein is FAM134B, which can bind LC3 proteins and mediate the degradation of
Bhaskara, R. , Bock, A., Bocker, H., Covarrubias-Pinto, A., Dikić, I., Foronda, H., Franzka, P., Fu, Y., Gleeson, J., González, A., Hoffmann, M., Hummer, G. , Hübner, C., Katona, I., Kessels, M., Koch, N., Kurth, I., Liebmann, L., Mari, M., Qualmann, B., Reggiori, F., Seemann, E., Weis, J.   +22 more
core   +5 more sources

RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway

Acta Biochimica et Biophysica Sinica, 2022
Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact mechanisms underlying ER-phagy in the pathogenesis of intervertebral disc degeneration remain largely
Luo Rongjin, Liang Huaizhen, Zhang Weifeng, Li Gaocai, Zhao Kangcheng, Hua Wenbin, Song Yu, Yang Cao   +7 more
doaj   +1 more source

ER-phagy at a glance [PDF]

Journal of Cell Science, 2018
ABSTRACT Selective autophagy represents the major quality control mechanism that ensures proper turnover of exhausted or harmful organelles, among them the endoplasmic reticulum (ER), which is fragmented and delivered to the lysosome for degradation via a specific type of autophagy called ER-phagy.
Grumati, Paolo, Dikic, Ivan, Stolz, Alexandra   +2 more
openaire   +3 more sources

MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B [PDF]

, 2022
Lysosomes are catabolic organelles devoted to the degradation of intracellular proteins and components. In addition, lysosomes are signalling hubs that orchestrate many intracellular responses.
IAVAZZO, MARIA
core   +1 more source

Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress [PDF]

Autophagy, 2020
Physiological and pathological stresses may cause swelling of the endoplasmic reticulum (ER), a biosynthetic organelle in eukaryotic cells. Upon conclusion of the stress, ER size and content return to physiological levels. The translocon component SEC62 decorates the portions of excess ER that must be cleared from cells. Our recent paper highlights the
Marisa Loi, Maurizio Molinari
openaire   +3 more sources

Foundations of ER-phagy regulation [PDF]

Nature Reviews Molecular Cell Biology, 2020
In their study in Cell Liang et al. identify 200 regulators of ER-phagy and specifically dissect the role of mitochondrial oxidative metabolism and protein UFMylation in promoting ER-phagy.
openaire   +2 more sources

Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model

Frontiers in Neuroscience, 2020
Studies demonstrated that spinal autophagy was impaired in spinal nerve ligation (SNL) rats. However, the relationship of endoplasmic reticulum (ER) stress and ER-phagy and whether dexmedetomidine (DEX) modulates ER-phagy remain unclear.
Yongda Liu, Yongda Liu, Shuang Wang, Zhibin Wang, Zhibin Wang, Mengmeng Ding, Mengmeng Ding, Xingyue Li, Xingyue Li, Jiao Guo, Jiao Guo, Guang Han, Guang Han, Ping Zhao, Ping Zhao   +14 more
doaj   +1 more source

Role of endoplasmic reticulum autophagy in acute lung injury

Frontiers in Immunology, 2023
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), the prime causes of morbidity and mortality in critically ill patients, are usually treated by general supportive treatments.
Shiping Liu, Xiaoyu Fang, Ruiyao Zhu, Jing Zhang, Huijuan Wang, Jiaxi Lei, Chaoqun Wang, Lu Wang, Liying Zhan   +8 more
doaj   +1 more source

ER-phagy: Eating the Factory [PDF]

Molecular Cell, 2020
Liang et al. (2020) reports on a genome-wide screen that reveals new aspects of starvation-induced degradation of the endoplasmic reticulum.
openaire   +2 more sources