Results 41 to 50 of about 3,252 (178)

MiR-142-5p/FAM134B Axis Manipulates ER-Phagy to Control PRRSV Replication

Frontiers in Immunology, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV) can replicate its RNA genome in endoplasmic reticulum (ER) and utilize ER to facilitate its assembly and maturation.
Kaifeng Guan, Qiuju Su, Kailin Kuang, Xiangge Meng, Xiang Zhou, Xiang Zhou, Bang Liu, Bang Liu, Bang Liu   +8 more
doaj   +1 more source

The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast.

PLoS Biology, 2023
Selective macroautophagy of the endoplasmic reticulum (ER) and the nucleus, known as ER-phagy and nucleophagy, respectively, are processes whose mechanisms remain inadequately understood. Through an imaging-based screen, we find that in the fission yeast
Chen-Xi Zou, Zhu-Hui Ma, Zhao-Di Jiang, Zhao-Qian Pan, Dan-Dan Xu, Fang Suo, Guang-Can Shao, Meng-Qiu Dong, Li-Lin Du   +8 more
doaj   +1 more source

A SELECTIVE ER-PHAGY EXERTS PROCOLLAGEN QUALITY CONTROL VIA A CALNEXIN-FAM134B COMPLEX [PDF]

, 2020
The endoplasmic reticulum (ER) is the largest cellular organelle adapting dynamically to cope with cellular stress and high demand of newly synthesized proteins.
DE LEONIBUS CHIARA
core   +1 more source

The various shades of ER‐phagy [PDF]

The FEBS Journal, 2019
Endoplasmic reticulum (ER) is a large and dynamic cellular organelle. ER morphology consists of sheets, tubules, matrixes, and contact sites shared with other membranous organelles. The capacity of the ER to fulfill its numerous biological functions depends on its continuous remodeling and the quality control of its proteome.
Stolz, Alexandra, Grumati, Paolo
openaire   +3 more sources

OsHLP1 is an endoplasmic-reticulum-phagy receptor in rice plants

Cell Reports, 2023
Summary: The endoplasmic reticulum (ER) is the largest intracellular endomembrane system; it shows dynamic changes upon environmental stress. To maintain ER morphology and homeostasis under stress, the excessive ER membrane and the associated unwanted ...
Yingbo Liang, Fanwei Meng, Xia Zhao, Xinyi He, Jun Liu   +4 more
doaj   +1 more source

Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. [PDF]

, 2022
Selective degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is initiated by ER-phagy receptors, which facilitate the incorporation of ER fragments into autophagosomes.
Aureli, Simone, Cinque, Laura, Cirillo, Carmine, Di Lorenzo, Giorgia, Efeyan, Alejo, Grumati, Paolo, Iavarone, Francescopaolo, Limongelli, Vittorio, Maddaluno, Marianna, Marin, Oriano, Napolitano, Gennaro, Palma, Alessandro, Pinna, Lorenzo A, Pinna, Lorenzo A., Plata-Gómez, Ana Belén, Quezada Meza, Camila Paz, Reggio, Alessio, Ruzzene, Maria, Sacco, Francesca, Settembre, Carmine, Stolz, Alexandra   +20 more
core   +1 more source

Signal-Retaining Autophagy Indicator as a Quantitative Imaging Method for ER-Phagy

Cells, 2023
Autophagy is an intracellular lysosomal degradation pathway by which cytoplasmic cargoes are removed to maintain cellular homeostasis. Monitoring autophagy flux is crucial to understand the autophagy process and its biological significance.
Natalia Jimenez-Moreno, Carla Salomo-Coll, Laura C. Murphy, Simon Wilkinson   +3 more
doaj   +1 more source

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis [PDF]

, 2018
Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health.
Adamson, Alain J. Kemp, Alex von Kriegsheim, Antonucci, Axe, B'Chir, Behrends, Chen, Christian Behrends, Cox, Deosaran, Di Bartolomeo, Diakopoulos, Dunlop, Edwards, Egan, Farré, Fracchiolla, Fumagalli, Gammoh, Ganley, Ge, Grasso, Grumati, Hailey, Hamasaki, Hara, Hashimoto, Hayashi-Nishino, Heo, Hess, Hosokawa, Houck, Huh, Huttlin, Ichimura, Itakura, Jia, Jimi Wills, Joo, Jung, Kamber, Khaminets, Khaminets, Kim, Kostenko, Kraft, Ktistakis, Lazarou, Lee, Lin, Lipatova, Liu, Longatti, Lum, Maejima, Mali, Margaret E. Harley, Mark Arends, Martin Lee, Matthew D. Smith, Mizushima, Mochida, Newman, Newman, Nguyen, Ogata, Pankiv, Pengo, Ran, Ravikumar, Rouschop, Russell, Simon Wilkinson, Slobodkin, Sowa, Teckman, Thurston, Tian, Tooze, Tooze, Torggler, Tsuboyama, Wang, Wild, Wisniewski, Wong, Zheng   +87 more
core   +1 more source

ROOT HAIR DEFECTIVE3 Is a Receptor for Selective Autophagy of the Endoplasmic Reticulum in Arabidopsis

Frontiers in Plant Science, 2022
ROOT HAIR DEFECTIVE3 (RHD3) is a plant member of atlastin GTPases, which belong to an evolutionally conserved family of proteins that mediate the homotypic fusion of the endoplasmic reticulum (ER).
Jiaqi Sun, Weina Wang, Huanquan Zheng
doaj   +1 more source

ER-phagy and human diseases

Cell Death & Differentiation, 2019
Autophagy regulates the degradation of unnecessary or dysfunctional cellular components. This catabolic process requires the formation of a double-membrane vesicle, the autophagosome, that engulfs the cytosolic material and delivers it to the lysosome. Substrate specificity is achieved by autophagy receptors, which are characterized by the presence of ...
Christian A. Hübner, Ivan Dikic
openaire   +3 more sources