Results 51 to 60 of about 3,252 (178)
Biomedicines, 2021 Acetaminophen (APA)-induced hepatotoxicity is coupled with the activation of autophagy. We sought to determine whether selective autophagy of the endoplasmic reticulum (ER), termed ER-phagy, is involved in APA hepatotoxicity and to explore its potential ...
Mingzhu Yan +6 more
doaj +1 more source
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone [PDF]
, 2019 Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until bone is remodeled. The interconnected osteocyte network within the
Vrahnas, Christina +17 more
core +1 more source
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]
, 2020 Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Arias-Muñoz, Eloisa +16 more
core +2 more sources
ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits [PDF]
, 2022 Fragments of the endoplasmic reticulum (ER) are selectively delivered to the lysosome (mammals) or vacuole (yeast) in response to starvation or the accumulation of misfolded proteins through an autophagic process known as ER-phagy.
Ferro-Novick, Susan +5 more
core +2 more sources
The N-Degron Pathway Mediates ER-phagy [PDF]
Molecular Cell, 2019 The endoplasmic reticulum (ER) is susceptible to wear-and-tear and proteotoxic stress, necessitating its turnover. Here, we show that the N-degron pathway mediates ER-phagy. This autophagic degradation initiates when the transmembrane E3 ligase TRIM13 (also known as RFP2) is ubiquitinated via the lysine 63 (K63) linkage.
Chang Hoon, Ji +13 more
openaire +2 more sources
Liver Research, 2018 The endoplasmic reticulum (ER) is an intracellular organelle consisting of a continuous network of membranes. In the liver, the ER is highly active in protein modification, lipid metabolism, and xenobiotic detoxification.
Xiaowen Ma, Clayre Parson, Wen-Xing Ding
doaj +1 more source
Cell biology: Receptors for selective recycling. [PDF]
, 2015 This is the author accepted manuscript. The final version is available from Nature at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14532 ...
Rubinsztein, David C
core +1 more source
Angewandte Chemie, EarlyView.A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley +2 more sources
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy
Cell Death and Disease, 2023 Autophagy of endoplasmic reticulum (ER-phagy) selectively removes damaged ER through autophagy-lysosome pathway, acting as an adaptive mechanism to alleviate ER stress and restore ER homeostasis.
Jinfei Yang +16 more
doaj +1 more source
Endoplasmic reticulum tubules limit the size of misfolded protein condensates
eLife, 2021 The endoplasmic reticulum (ER) is composed of sheets and tubules. Here we report that the COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor, RTN3, to target dominant-interfering mutant proinsulin Akita puncta to ...
Smriti Parashar +9 more
doaj +1 more source