Results 61 to 70 of about 3,252 (178)

Dexmedetomidine and Ketamine Attenuated Neuropathic Pain Related Behaviors via STING Pathway to Induce ER-Phagy

Frontiers in Synaptic Neuroscience, 2022
Our previous work indicated that ER-phagy level had altered in spinal nerve ligation (SNL) rats. In this study, we investigated whether dexmedetomidine or ketamine exhibits anti-anxiety or anti-nociceptive effects via modulation of the spinal STING/TBK ...
Yongda Liu, Shihui Kuai, Mengmeng Ding, Zhibin Wang, Limei Zhao, Ping Zhao   +5 more
doaj   +1 more source

Intrinsically Disordered Protein TEX264 Mediates ER-phagy [PDF]

Molecular Cell, 2019
Certain proteins and organelles can be selectively degraded by autophagy. Typical substrates and receptors of selective autophagy have LC3-interacting regions (LIRs) that bind to autophagosomal LC3 and GABARAP family proteins. Here, we performed a differential interactome screen using wild-type LC3B and a LIR recognition-deficient mutant and identified
Haruka, Chino, Tomohisa, Hatta, Tohru, Natsume, Noboru, Mizushima   +3 more
openaire   +2 more sources

Emerging Principles of Selective ER Autophagy [PDF]

, 2019
The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and signal transduction. It is subject to complex, dynamic sculpting of morphology and composition. Degradation of ER content has an important role to play here.
Wilkinson, Simon
core   +1 more source

Autophagy, ER-phagy and ER Dynamics During Cell Differentiation.

J Mol Biol
The endoplasmic reticulum (ER) is a multifunctional organelle essential for protein and lipid synthesis, ion transport and inter-organelle communication. It comprises a highly dynamic network of membranes that continuously reshape to support a wide range of cellular processes.
Cillo M, Buonomo V, Vainshtein A, Grumati P.   +3 more
europepmc   +4 more sources

Visualizing ER-phagy and ER architecture in vivo. [PDF]

J Cell Biol
ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how ER-phagy and the ER network vary across cell subtypes, tissues, and organs. Furthermore, the pathophysiological relevance of ER-phagy remains poorly elucidated. Addressing these questions requires
Sang Y, Li B, Su T, Zhan H, Xiong Y, Huang Z, Wang C, Cong X, Du M, Wu Y, Yu H, Yang X, Ding K, Wang X, Miao X, Gong W, Wang L, Zhao J, Zhou Y, Liu W, Hu X, Sun Q.   +21 more
europepmc   +3 more sources

ER-phagy:shaping up and de-stressing the endoplasmic reticulum [PDF]

, 2019
The endoplasmic reticulum (ER) network has central roles in metabolism and cellular organisation. The ER undergoes dynamic alterations in morphology, molecular composition and functional specification.
An H, Anding AL, Antonucci L, Bergmann TJ, Bernales S, Birgisdottir AB, Bolender RP, Cadwell K, Caldieri G, Chen Q, Chen S, Chino H, Chiramel AI, Cinque L, Codogno P, Cubillos‐Ruiz JR, Diakopoulos KN, Dikic I, Dikic I, Dooley HC, Durr A, English AR, English L, Farre JC, Farre JC, Farre JC, Forrester A, Fregno I, Fregno I, Fry MR, Fujita E, Fumagalli F, Gammoh N, Ganley IG, Ge L, Grumati P, Grumati P, Guan J, Hailey DW, Hamasaki M, Hanna RA, Hayashi-Nishino M, Holcman D, Hotamisligil GS, Houck SA, Huh WJ, Islam F, Islam F, Jia W, Khaminets A, Khaminets A, Koh JH, Kostenko EV, Kurth I, Lamb CA, Lennemann NJ, Liang JR, Linxweiler M, Lipatova Z, Liu XM, Liu Y, Locke M, Martinez J, Mejlvang J, Mijaljica D, Mochida K, Moretti J, Nakatogawa H, Noda T, Ogata M, Oku M, Oku M, Oku M, Omari S, Pahl HL, Pang L, Papinski D, Peng Y, Pengo N, Phillips MJ, Polson HEJ, Puri C, Ravenhill BJ, Rello-Varona S, Richter B, Rogov V, Rogov VV, Ruggiano A, Sahu R, Sanjuan MA, Schroeder LK, Schuck S, Schultz ML, Shi Q, Shi W, Smith M, Smith MD, Smith MD, Todd DJ, Tooze J, Tschurtschenthaler M, Turco E, Vargas JNS, Viswanath P, Voeltz GK, Walter P, Wang M, Wild P, Yamamoto H, Yang H, Yang Y, Yla-Anttila P, Zachari M, Zhang H   +113 more
core   +1 more source

Signaling Regulation of FAM134-Dependent ER-Phagy in Cells. [PDF]

J Cell Physiol
ABSTRACTThe endoplasmic reticulum (ER) is a pivotal organelle responsible for protein and lipid synthesis, calcium homeostasis, and protein quality control within eukaryotic cells. To maintain cellular health, damaged or excess portions of the ER must be selectively degraded via a process known as selective autophagy, or ER‐phagy.
Palma A, Reggio A.
europepmc   +4 more sources

Eat it right: ER-phagy and recovER-phagy [PDF]

Biochemical Society Transactions, 2018
The endoplasmic reticulum (ER) is the site of protein, lipid, phospholipid, steroid and oligosaccharide synthesis and modification, calcium ion storage, and detoxification of endogenous and exogenous products. Its volume (and activity) must be maintained under normal growth conditions, must be expanded in a controlled manner on activation of ER stress ...
Loi, Marisa, Fregno, Ilaria, Guerra, Concetta, Molinari, Maurizio   +3 more
openaire   +3 more sources

Critical roles of FAM134B in ER-phagy and diseases [PDF]

Cell Death & Disease, 2020
AbstractFAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor.
Mo, Jie, Chen, Jin, Zhang, Bixiang
openaire   +2 more sources

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

, 2019
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms.
Charlotta Funaya, Dimitrios Papagiannidis, Giulia Ruffini, Jasmin A Schäfer, Julia P Schessner, Katharina Schaeff, Michael Knop, Oliver Pajonk, Peter W Bircham, Sebastian Schuck, Takuma Tsuji, Toyoshi Fujimoto, Vergères G   +12 more
core   +2 more sources