Results 71 to 80 of about 3,252 (178)
ER-Phagy: Selective Autophagy of the Endoplasmic Reticulum [PDF]
Autophagy, 2007 Throughout their life, cells must maintain homeostasis while facing constantly fluctuating demands on their different organelles. A major mechanism for the homeostatic control of organelle function is the unfolded protein response (UPR), a signaling pathway that triggers a comprehensive remodeling of the endoplasmic reticulum (ER) and the biosynthetic ...
Sebastián, Bernales +2 more
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Mechanisms and physiological functions of ER-phagy
Current Opinion in Physiology, 2022 The endoplasmic reticulum (ER) is the largest cellular organelle that undergoes constant turnover upon diverse functional demands and cellular signals. Removal of nonfunctional or superfluous subdomains is balanced by the parallel expansion and formation of ER membranes, leading to the dynamic exchange of ER components.
Pablo Sanz-Martinez, Alexandra Stolz
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A Role for Macro-ER-Phagy in ER Quality Control. [PDF]
PLoS Genetics, 2015 The endoplasmic-reticulum quality-control (ERQC) system shuttles misfolded proteins for degradation by the proteasome through the well-defined ER-associated degradation (ERAD) pathway. In contrast, very little is known about the role of autophagy in ERQC.
Zhanna Lipatova, Nava Segev
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Ethanol Effects Involve Non-canonical Unfolded Protein Response Activation in Yeast Cells [PDF]
, 2017 The unfolded protein response (UPR) is a conserved intracellular signaling pathway that controls transcription of endoplasmic reticulum (ER) homeostasis related genes.
Navarro Tapia, Elisabet +2 more
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Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity
Cell ReportsSummary: ER-phagy, a selective autophagy targeting the endoplasmic reticulum (ER) for lysosomal degradation through cargo receptors, plays a critical role in ER quality control and is linked to various diseases.
Wenqing Mou +4 more
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A Dual Binding Receptor for ER-phagy [PDF]
Developmental Cell, 2018 Selective autophagy of the endoplasmic reticulum (ER)-ER-phagy-is mediated by multiple receptors. In this issue of Developmental Cell, Smith et al. (2018) identify ER membrane protein CCPG1 as an ER-phagy receptor that interacts with autophagy-related proteins GABARAPs and FIP200 and ensures ER protein homeostasis, especially in pancreatic acinar cells.
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Characterization of Constitutive macro-ER-phagy [PDF]
, 2020 AbstractThirty percent of all cellular proteins are inserted into the endoplasmic reticulum (ER), which spans throughout the cytoplasm. Two well-established stress-induced pathways ensure quality control (QC) at the ER: ER-phagy and ER-associated degradation (ERAD), which shuttle cargo for degradation to the lysosome and proteasome, respectively.
Zhanna Lipatova +3 more
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The role of autophagy in liver epithelial cells and its Impact on systemic homeostasis [PDF]
, 2019 Autophagy plays a role in several physiological and pathological processes as it controls the turnover rate of cellular components and influences cellular homeostasis.
Facchiano, Antonio +9 more
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PLoS Genetics, 2020 Autophagy is a fundamental process responsible for degradation and recycling of intracellular contents. In the budding yeast, non-selective macroautophagy and microautophagy of the endoplasmic reticulum (ER) are caused by ER stress, the circumstance ...
Tomoaki Mizuno, Kei Muroi, Kenji Irie
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ER stress as a trigger of UPR and ER-phagy in cancer growth and spread
Frontiers in Oncology, 2022 Tumors can survive environmental and metabolic stress by triggering homeostatic responses that re-establish the pre-stress status and permit them to grow and thrive.
Alessandro Cherubini +3 more
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