Results 261 to 270 of about 1,308,915 (353)

XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease

, 2019
Katarzyna A. Piróg, Ella P. Dennis, Claire Hartley, Robert M. Jackson, Jamie Soul, Jean‐Marc Schwartz, John F. Bateman, Ray Boot-Handford, Michael D. Briggs   +8 more
openalex   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes. [PDF]

Front Cell Infect Microbiol
Zhao W, Chen L, Qing J, Zhao Z, Xiong L, Tong P, Huang Z, Chen Y.   +7 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Disrupted glycosylphosphatidylinositol anchoring induces ER stress and restricts enterovirus infection. [PDF]

PLoS Pathog
Guo S, Li X, Xun M, He Y, Tai AW, Wang H.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Age-dependent induction of ER stress in retinal pigment epithelium impairs phagocytosis via ADAM17-dependent MERTK shedding. [PDF]

J Biol Chem
Yasuda H, Nakamura S, Shirakawa A, Kuse Y, Mori K, Shimazawa M.   +5 more
europepmc   +1 more source

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

, 2016
Yogesh Bhootada, Pravallika Kotla, Sergei Zolotukhin, Oleg S. Gorbatyuk, Zsuzsanna Bebök, Mohammad Athar, Marina S. Gorbatyuk   +6 more
openalex   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Sec61β maintains cytoplasmic proteostasis via ARIH1-mediated translational repression upon ER stress. [PDF]

EMBO Rep
Kadowaki H, Hatta T, Sugiyama K, Fukaya T, Fujisawa T, Hamano T, Murao N, Takami Y, Mitoma S, Natsume T, Sato K, Hirata H, Uechi T, Nishitoh H.   +13 more
europepmc   +1 more source