Results 251 to 260 of about 1,308,915 (353)

Beyond ER Stress: The Pleiotropic Roles of XBP1 in Development and Regeneration. [PDF]

Biomedicines
Huang D, Gu F, Ma J, Chen Z.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

4-Phenylbutyrate mitigates renal pathology linked to ER stress related pathways in C57BL/6J mice with hindlimb unloading. [PDF]

Sci Rep
Ranade AV, Bernhardt GV, Jose J, Ramachandran G, Ebby S, Karim A, Ahmad F, Qaisar R, Gowda KMD.   +8 more
europepmc   +1 more source

PERP-ing the points of contact between ER and plasma membrane: modulation of ER stress and apoptosis in uveal melanoma

, 2019
Luminita Paraoan
openalex   +1 more source

5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response [PDF]

Hanyong Jin, Ji‐Hyun Yeom, Eunkyoung Shin, Hye‐Jeong Ha, Haifeng Liu, Daeyoung Kim, Minju Joo, Yong‐Hak Kim, Hak Kyun Kim, Minkyung Ryu, Hong-Man Kim, Jeongkyu Kim, Keun Pil Kim, Yoonsoo Hahn, Jeehyeon Bae, Kangseok Lee   +15 more
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The critical role of GRP78/BiP MARylation in ER stress of KRAS-mutant colorectal cancer. [PDF]

JCI Insight
Zhang S, Chen X, Gong Q, Huang J, Tang Y, Xiao M, Li M, Li Q, Wang Y.   +8 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

NEAT1 drives SARS-CoV-2 N protein-induced inflammation, metabolic reprogramming, and mitochondria-ER stress crosstalk. [PDF]

Sci Rep
Qing C, Chen H, Huang S, Zhang J, Zhou C, Zhang S, Luo K, Wang C, Hu Z, Yang Y, Zhou J, Zeng Z.   +11 more
europepmc   +1 more source