Results 181 to 190 of about 6,026 (227)

ERAP1 as an emerging therapeutic target for medulloblastoma

Trends in Cancer, 2022
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB).
Bufalieri F., Fruci D., Di Marcotullio L.   +2 more
openaire   +2 more sources

ERAP1 and the return of the UPR in ankylosing spondylitis

Nature Reviews Rheumatology, 2023
N. Haroon, R. Inman
semanticscholar   +3 more sources

THU0364 Rare Erap1 Allotype Combinations Do Not Explain The ERAP1 Association with Ankylosing Spondylitis

Annals of the Rheumatic Diseases, 2016
Background Single nucleotide polymorphisms (SNPs) in ERAP1 are strongly associated with ankylosing spondylitis (AS) (1,2). ERAP1 is an aminopeptidase involved in the generation of optimal peptide epitopes for presentation by T-cells in the context of major histocompatibility complex (MHC) class I molecules such as HLA-B27.
Appleton, LH, Roberts, AR, Vecellio, M, Wordsworth, BP   +3 more
openaire   +2 more sources

ERAP1 in the pathogenesis of ankylosing spondylitis

Immunologic Research, 2014
The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within ERAP1 as being ...
Reeves, Emma, Elliott, Tim, James, Edward, Edwards, Christopher J.   +3 more
openaire   +3 more sources

Polymorphisms in ERAP1 gene are associated with psoriasis

Meta Gene, 2022
Abstract Background Several polymorphisms in ERAP1 gene has been reported to be associated with psoriasis in several different populations. Objective To better understand the association between ERAP1 and psoriasis in Chinese Han population. Methods Seven SNPs (rs27044, rs27043, rs26510, rs469758, rs30378, rs30186 and rs2303208) in ERAP1 ...
Weiwei Chen, Liang Yong, Huiyao Ge, Qiongqiong Xu, Qi Zhen, Bao Li, Yafen Yu, Jing Wu, Xiaodong Zheng, Jinping Gao, Bo Liang, Hui Cheng, Liangdan Sun, Wenjun Wang   +13 more
openaire   +1 more source

The role of ERAP1 in autoinflammation and autoimmunity

Human Immunology, 2019
Autoimmune and autoinflammatory diseases affect millions worldwide. These classes of disease involve abnormal immune activation of both the innate and adaptive immune systems. While both classes of disease represent a spectrum of aberrant immune activation, excessive activation of the innate immune system has been considered causal for the inflammation
Yuliya Pepelyayeva, Andrea Amalfitano
openaire   +2 more sources

Investigating the genetic association between ERAP1 and spondyloarthritis

Annals of the Rheumatic Diseases, 2013
A robust association between polymorphisms in the non-major histocompatibility complex gene ERAP1 and ankylosing spondylitis (AS) in several populations was recently identified. The aim of the current study was to determine the level of association of ERAP1 polymorphisms with spondyloarthritis (SpA) in French/Belgian populations with particular ...
Amir, Kadi, Brigitte, Izac, Roula, Said-Nahal, Ariane, Leboime, Liesbet, Van Praet, Kurt, de Vlam, Dirk, Elewaut, Gilles, Chiocchia, Maxime, Breban   +8 more
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ERAP1-dependent extreme antigen processing efficacy can govern MHC class I expression hierarchy.

Journal of Immunology
Peptide presentation by major histocompatibility complex (MHC) class I molecules enables CD8+ T lymphocytes to monitor the intracellular proteome of tissue cells.
Jacqueline Leib, Emmanuelle Waeckel-Énée, S. Fabrega, Nadia Keelan, Alice Senni, François-Xavier Mauvais, R. Deprez-Poulain, Barbara Bertocci, Peter M van Endert   +8 more
semanticscholar   +1 more source

Exploring associations of single nucleotide polymorphisms in ERAP1 and ERAP2 with susceptibility to multiple immune-mediated inflammatory diseases.

Human Immunology
Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 genes have been associated with susceptibility to various immune-mediated inflammatory diseases (IMIDs).
Sofie Jørgensen, T. Bertelsen, Lasse Kronborg, A. Dige, T. B. Laurberg, A. G. Loft, J∅rgen Agnholt, K. F. Hjuler, Claus Johansen   +8 more
semanticscholar   +1 more source

ERAP1 shapes just part of the immunopeptidome

Human Immunology, 2019
ERAP1 is an aminopeptidase involved in trimming long peptides to the lengths required for presentation by MHC class I. ERAP1 substrate preference is for peptides with hydrophobic or aliphatic N-terminal amino acids, with lower efficacy with charged and small hydrophilic amino acids and almost complete inefficiency with proline.
openaire   +2 more sources