Results 191 to 200 of about 6,026 (227)

The association of HLA-DRB1 allele group but not HLA-B or ERAP1-rs7063 gene polymorphisms with atopic dermatitis.

Human Immunology
Atopic dermatitis (AD) is one of the most common dermatoses. According to current data 2.6 % of the world's population suffer from AD. Atopic dermatitis is a multifactorial disease.
Wanda Niepiekło-Miniewska, Ł. Matusiak, J. Narbutt, A. Lesiak, P. Kuna, Jacek C. Szepietowski, Piotr Kuśnierczyk   +6 more
semanticscholar   +1 more source

Inhibition of ERAP1 represses HLA-B27 free heavy chains expression on polarized macrophages and interrupts NK cells activation and function from ankylosing spondylitis.

Clinical Immunology, 2023
BACKGROUND We aimed to assess if Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms might impress Human leukocyte antigen (HLA)-B27-free heavy chains (FHCs) expression on macrophages and eventually NK cell activation in Ankylosing spondylitis ...
F. Babaie, Hamed Mohammadi, Sorayya Salimi, Alireza Ghanavatinegad, M. Abbasifard, M. Yousefi, Mehrzad Hajaliloo, Younes Khalili, Sajjad Zamanlou, Roghaiyeh Safari, M. Hemmatzadeh, Alireza Rezaiemanesh, Reza Salimi, B. Baradaran, Z. Babaloo   +14 more
semanticscholar   +1 more source

ERAP1Is Associated with Ankylosing Spondylitis in Han Chinese

The Journal of Rheumatology, 2010
Objective.Genetic components play important roles in the incidence and development of ankylosing spondylitis (AS). Aminopeptidase regulator of tumor necrosis factor receptor shedding 1 (ERAP1) was recently found to be associated with AS in North American and British cohorts.
Chao, Li, Zhiming, Lin, Yingying, Xie, Zishi, Guo, Jinxian, Huang, Qiujing, Wei, Qiu Xia, Li, Xinwei, Wang, Shuangyan, Cao, Zetao, Liao, Manlong, Xu, Yan, Shen, Jieruo, Gu   +12 more
openaire   +2 more sources

Exploring the genetic interaction between ERAP1/ERAP2 and HLA-B*52:01 in Takayasu arteritis.

Rheumatology
OBJECTIVES Takayasu arteritis is a rare vasculitis characterized by inflammation of large arteries. Given the robust genetic association with HLA-B*52:01, it was recently proposed to classify Takayasu arteritis within the spectrum of MHC-I-opathies ...
Desiré Casares-Marfil, G. Saruhan-Direskeneli, P. C. Grayson, E. Tombetti, Lindi Jiang, Peter A. Merkel, H. Direşkeneli, A. H. Sawalha   +7 more
semanticscholar   +1 more source

Shedding new light on the role of ERAP1 in Type 1 diabetes: A perspective on disease management.

Autoimmunity Reviews, 2023
Type 1 diabetes mellitus (T1D) is a multifactorial organ specific autoimmune disease which originates from the destruction of insulin-producing beta cells within the pancreatic islets by autoreactive CD8+ T lymphocytes.
Giorgia Paldino, A. Fierabracci
semanticscholar   +1 more source

Evaluation of the role of ERAP1, RUNX3, and HLA-C genes in Iraqi patients with psoriasis: A histopathological study

Asia-Pacific Journal of Molecular Biology and Biotechnology
Psoriasis is a chronic disease caused by an overactive immune status, leading to the rapid multiplication of the skin cells and the formation of scaly, inflamed patches on various parts of the body.
W. A. Jawad, N. Majeed
semanticscholar   +1 more source

Behcet’s patient-derived HLA class I immunopeptidome is ERAP1-dependent and displays disease-specific candidate peptides 4513

Journal of Immunology
Specific HLA I (HLA-B51) confers risk for Behcet’s disease (BD), augmented by allotypic ERAP1 with low peptide trimming activity. We previously demonstrated the impact of ERAP1 KO on the HLA I/ B51 peptidome in a genome-edited in vitro model. Here,
Ali Bordbar Haghighi Sabet, Olivier Manches, A. K. Aydin, Y. Ozguler, B. S. Yaylaz, G. Workalemahu, Nihal Esatoglu, D. Uçar, Nihan Aksu, M. Oray, İ. Tuğal-Tutkun, Matthias C Kugler, Ioana Clotea, Beatrix M. Uberheide, G. Hatemi, J. Nowatzky   +15 more
semanticscholar   +1 more source

FRI0195 ERAP1 Allotypes and Disease Severity in Ankylosing Spondylitis

Annals of the Rheumatic Diseases, 2015
Background ERAP1 trims peptides to the correct length to fit into the binding groove of MHC class I allowing antigen presentation. The association of ERAP1 with Ankylosing Spondylitis (AS) has been confirmed in a number of studies in both Caucasian and Asian cohorts, and requires the presence of HLA-B27.
W. Fong, E. Reeves, W. Tim, T. Elliot, E. James, C.J. Edwards   +5 more
openaire   +1 more source

P-353 The role of endoplasmic reticulum aminopeptidases 1/2 (ERAP1/ERAP2) and cysteinyl aminopeptidase (LNPEP) in the pathomechanism of endometriosis - a study of genetic and proteomic determinants

Human Reproduction
How might ERAP1, ERAP2 and LNPEP polymorphisms and levels of these aminopeptidases tested in plasma and peritoneal fluid be related to endometriosis susceptibility and severity?
P. Bochen, A. Tarnowska, A. Wiśniewski, M. Wilczyński, A. Malinowski, E. Leśniak, J. Bieńkiewicz, A. Fuchs-Ciesielska, A. Hurnik-Szurkiewicz, L. Strubel–Majewska, J. Pająk, A. Chrobak, I. Nowak   +12 more
semanticscholar   +1 more source

ERAP1 and MHC Class I Antigen Presentation

2004
Cytotoxic T lymphocytes (CTLs) are the principal mediators of immune responses against intracellular pathogens or tumors and recognize on the surface of target cells peptide fragments derived from foreign protein antigens bound to major histocompatibility complex (MHC) class I molecules.
Tomo Saric, Alfred L. Goldberg
openaire   +1 more source