Results 101 to 110 of about 95,906 (268)

Interaction between ErbB‐1 and ErbB‐2 transmembrane domains in bilayer membranes

FEBS Letters, 2002
The transmembrane domains of ErbB receptor tyrosine kinases are monotopic helical structures proposed to be capable of direct side‐to‐side contact with related receptors. Formation of the resulting homo‐ or hetero‐oligomeric complexes is considered a key step in ligand‐mediated signalling.
Sharpe, Simon, Barber, Kathryn R., Grant, Chris W.M.   +2 more
openaire   +2 more sources

Genetic and Molecular Determinants of Familial Transmission of Skeletal Malocclusions

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Families studies conducted in different ethnic populations worldwide have helped elucidate the molecular and genetic factors involved in the development of skeletal class III malocclusion. Therefore, the aim of this study is to provide an updated summary.
Alexandra Dehesa‐Santos, Lucia Carreño‐Gomez, Rosa Yañez‐Vico, Alejandro Iglesias‐Linares   +3 more
wiley   +1 more source

Molecular markers (c-erbB-2, p53) in breast cancer.

Folia Histochemica et Cytobiologica, 2009
The aim of our study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues. Breast cancer tissue was obtained from 184 female subjects with primary breast cancer.
Piotr Zukrowski, Zygmunt Grzebieniak, Jerzy Rudnicki, Michał Jeleń, Anil Kumar Agrawal, Ewa Nienartowicz   +5 more
doaj   +1 more source

Altered peripheral CRY1 gene expression may contribute to both organic and functional gastrointestinal disease

Experimental Physiology, EarlyView.
ABSTRACT Gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are characterized by alterations in physiological and immune functions. Given the circadian clock influences gastrointestinal physiology and immunity, we hypothesized that the peripheral circadian clock is altered in these patients and ...
Sophie Fowler, Gemma M. Paech, Emily C. Hoedt, Jennifer C. Pryor, Cheenie Nieva, Jessica K. Bruce, Prema M. Nair, Guy D. Eslick, Simonne Sherwin, Peter Pockney, Nicholas J. Talley, Grace L. Burns, Simon Keely   +12 more
wiley   +1 more source

Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia

Scientific Reports, 2017
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen   +2 more
doaj   +1 more source

Arrhythmic expression signatures of circadian clock‐associated transcription factors and chronic circadian disruption contribute to advanced prostate cancer growth

International Journal of Cancer, Volume 158, Issue 3, Page 775-789, 1 February 2026.
What's new? Circadian rhythm disruption potentially fuels prostate cancer progression. The mechanisms and signaling molecules contributing to hormonal tumorigenesis, however, remain largely undefined. In this study, circadian expression patterns of core‐circadian controlled genes (CCCGs) and nuclear receptors (NRs) were investigated in advanced ...
Ria Chopra, Haolong Li, Wenjuan Xie, Daniel Hau Tak Lam, Franky Leung Chan   +4 more
wiley   +1 more source

Single‐cell multi‐omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC‐unique features

International Journal of Cancer, Volume 157, Issue 12, Page 2619-2634, 15 December 2025.
What's New? Patient‐derived organoids provide a promising platform for modeling colorectal cancer. The authors demonstrated that organoids derived from normal colorectal tissue recapitulate the cellular composition and differentiation trajectory of colorectal crypts.
Zhijun Yu, Merel Derksen, Brigit M. te Pas, Sabrina Ladstätter, Rene Overmeer, Peter Brazda, Marc van de Wetering, Farzin Pourfarzad, Robert G. J. Vries, Wout Megchelenbrink, Christoph Bock, Lucia Altucci, Hendrik G. Stunnenberg   +12 more
wiley   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, Volume 15, Issue 12, Page 2045-2053, December 2025.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury [PDF]

, 2019
Katalin Bartus, Emily R. Burnside, Jorge Galino, Nicholas D. James, David Bennett, Elizabeth J. Bradbury   +5 more
openalex   +1 more source

ErbB Signalling is a Potential Therapeutic Target for Vascular Lesions with Fibrous Component [PDF]

, 2022
Henna Ilmonen, Suvi Jauhiainen, Pia Vuola, Heta Rasinkangas, H. H. Pulkkinen, Sara Keränen, Miika Kiema, Jade J Liikkanen, Nihay Laham-Karam, Svetlana Laidinen, Einari Aavik, Kimmo Lappalainen, Jouko Lohi, Johanna Aronniemi, Tiit Örd, Minna U. Kaikkonen, Päivi Salminen, Erkki Tukiainen, Seppo Ylä‐Herttuala, Johanna P. Laakkonen   +19 more
openalex   +1 more source