Results 121 to 130 of about 95,906 (268)

Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Introduction Myostatin (MSTN), a transforming growth factor‐beta (TGF‐β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes augmentation in skeletal muscle mass in all animal species examined.
Xiangpeng Liu, Changyou Song, Yan Xiong, Jinxin Gu, Lianxin Wu, Taole Liu, Xiyue Chen, Hui Shu, Yingying Dong, Tizhong Shan, Sheng Wang, Yucheng Zhu, Tongxing Song, Lei Fu, Yaqiu Lin, Can Liu, Ruiqi Zheng, Xiao Zhao, Hongxia Li, Yong Xu, Shihuan Kuang, Han Wang, Bin Guo, Pao Xu, Zhihao Jia   +24 more
wiley   +1 more source

A Peptide Antagonist of the ErbB1 Receptor Inhibits Receptor Activation, Tumor Cell Growth and Migration In Vitro and Xenograft Tumor Growth In Vivo

Cellular Oncology, 2010
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in tumorigenesis and cancer disease progression, and therefore has become an attractive target for structure-based drug design.
Ruodan Xu, Gro Klitgaard Povlsen, Vladislav Soroka, Elisabeth Bock, Vladimir Berezin   +4 more
doaj   +1 more source

The Neuroimmunome of Hepatitis Patients Associates With Disease Severity

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT Hepatitis is a systemic disease marked by neuroimmune dysregulation beyond hepatic inflammation. Using a systems biology approach, we conducted transcriptomic meta‐analyses across in vitro models, liver tissues, and PBMCs from hepatitis virus‐infected patients to identify neuroimmune signatures.
Adriel Leal Nóbile, Anny Silva Adri, Júlia Nakanishi Usuda, Fernando Yuri Nery do Vale, Yohan Lucas Gonçalves Corrêa, Débora Gomes de Albuquerque Freitas, Roseane Galdioli Nava, Pedro Marçal Barcelos, Lena F. Schimke, Taj Ali Khan, Renato Santana de Aguiar, Niels Olsen Camara, Gustavo Cabral‐Miranda, Rodrigo J. S. Dalmolin, Helder I. Nakaya, Luiz Fernando Onuchic, Haroldo Dutra Dias, Igor Salerno Filgueiras, Otavio Cabral‐Marques   +18 more
wiley   +1 more source

Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma

São Paulo Medical Journal
CONTEXT: p53, c-erbB-2 and epidermal growth factor receptor (EGFR) are cancer-related proteins that are usually expressed in head and neck squamous cell carcinoma (SCC). Their prognostic value remains controversial.
Orlando Parise Junior, Leda Viegas Carvalho, Roberto Elias Villela Miguel, Luiz Paulo Kowalski   +3 more
doaj   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source

Metaphase and Interphase Cytogenetics with Alu-PCR-amplified Yeast Artificial Chromosome Clones Containing the BCR Gene and the Protooncogenes c-raf-1, c-fms, and c-erbB-21 [PDF]

, 1992
A human yeast artificial chromosome (YAC) library was screened by polymerase chain reaction with oligonucleotide primers defined for DNA sequences of the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erB-2.
Becher, Reinhard, Cremer, Thomas, Green, Eric D., Konecki, David, Lengauer, Christoph, Olson, Maynard V., Riethman, Harold C., Speicher, Michael R., Taniwaki, Masafumi   +8 more
core  

Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity [PDF]

, 2004
Bose Kochupurakkal, Daniel Harari, Ayelet Di‐Segni, Galia Maik-Rachline, Ljuba Lyass, Gal Gur, Gabriele Kerber, Ami Citri, Sara Lavi, Raya Eilam, Vered Chalifa‐Caspi, Zelig Eshhar, Eli Pikarsky, Ronit Pinkas‐Kramarski, Sarah Bacus, Yosef Yarden   +15 more
openalex   +1 more source

A Global Transcriptomic Analysis Reveals Body Weight‐Specific Molecular Responses to Chronic Orange Juice Consumption in Healthy Individuals

Molecular Nutrition &Food Research, Volume 69, Issue 24, December 2025.
This study aimed to investigate the molecular pathways involved in the health benefits of chronic orange juice (OJ) consumption through global transcriptomic approach in peripheral blood mononuclear cells (PBMCs). Healthy volunteers consumed 500 mL of OJ daily for 60 days.
Layanne Nascimento Fraga, Dragan Milenkovic, Isabella de Araújo Esteves Duarte, Saivageethi Nuthikattu, Camille Perella Coutinho, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto   +6 more
wiley   +1 more source

ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells [PDF]

, 2009
Dan-Dan Li, Xiao-Qi Wu, Jun Tang, Xiao-Yi Wei, Xiao‐Feng Zhu   +4 more
openalex   +1 more source

Breast Cancer Brain Metastasis: Bridging Biological Mechanisms to Therapeutic Innovations

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Breast cancer brain metastasis (BCBrM) is driven by a multistep metastatic cascade and shaped by dynamic tumor–brain interactions. This review integrates current mechanistic insights, from molecular signaling pathways to immune evasion, and evaluates preclinical models and emerging therapies.
Jing Feng, Yuwei Tao, Fengkai Li, Suling Liu   +3 more
wiley   +1 more source