Results 71 to 80 of about 61,149 (183)

The Dipole Potential Influences the Clustering of ErbB Proteins [PDF]

open access: bronze, 2015
Tamás Kovács   +3 more
openalex   +1 more source

Feedback regulation between histone H3 lysine 18 lactylation and TROP2‐mediated glycolysis drives metastatic progression of colorectal cancer

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TROP2 is upregulated in CRC metastasis and promotes lactate overproduction via YBX1‐HIF‐1α signalling. TROP2 signalling induces H3K18la at metastasis genes promoters in CRC and promotes their expression. AccLactate sustains TROP2 expression in CRC cells via H3K18la Acriflavine suppresses TROP2‐driven CRLM by targeting the H3K18la/TROP2 feedback loop ...
Weifeng Wang   +17 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli   +8 more
wiley   +1 more source

c-erbB-4 protein expression in human breast cancer [PDF]

open access: hybrid, 2000
Thean Yean Kew   +8 more
openalex   +1 more source

Synergistic Strategies in Systemic Therapy for Advanced Hepatocellular Carcinoma

open access: yesGlobal Challenges, Volume 10, Issue 1, January 2026.
This article comprehensively examines the evolving landscape of systemic therapy for advanced hepatocellular carcinoma. It covers the progress in tyrosine kinase inhibitors and immune checkpoint inhibitors, analyzes the efficacy of novel combination strategies, and discusses current challenges like drug resistance and the lack of biomarkers.
Yongxin Yu   +5 more
wiley   +1 more source

Expression and Characterization of Kinase‐active v‐erbB Protein Using a Baculovirus Vector System [PDF]

open access: hybrid, 1992
Kaoru Morishita   +6 more
openalex   +1 more source

Association of an Algorithm‐Generated Medication Optimization Score With Clinical Outcomes in Ambulatory Patients With Heart Failure

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.
ABSTRACT Aims Guideline‐directed medical therapy (GDMT) implementation in heart failure with reduced ejection fraction (HFrEF) remains suboptimal. A computable algorithm was developed to generate a medication optimization score (MOS) and provide guideline‐based recommendations.
Mohamed S. Ali   +5 more
wiley   +1 more source

Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity [PDF]

open access: hybrid, 2004
Bose Kochupurakkal   +15 more
openalex   +1 more source

Increased activation of ErbB and NFκB signalling pathways in Darier disease affected skin

open access: yes
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Nancy Ernst   +2 more
wiley   +1 more source

Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in Mice

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
Graded calorie restriction in male mice modified epigenetic signatures of the liver and slowed ageing rate in a graded manner. ABSTRACT DNA methylation variation is associated with chronological ageing. Calorie restriction (CR) prolongs lifespan and healthspan in many species.
Timothy P. Moulds   +6 more
wiley   +1 more source

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