L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]
PLoS ONE, 2012 During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Emanuelle Donier +6 more
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Role of ErbB receptors in cancer cell migration and invasion [PDF]
Frontiers in Pharmacology, 2015 Growth factors mediate their diverse biologic responses (regulation of cellular proliferation, differentiation, migration and survival) by binding to and activating cell-surface receptors with intrinsic protein kinase activity named Receptor Tyrosine ...
Aline eAppert-Collin +4 more
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Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer [PDF]
Biomedicines, 2023 Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory ...
Antonio Villalobo
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Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma [PDF]
Frontiers in Medicine, 2023 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is ...
Camilla Palumbo +13 more
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Genomic alterations of ERBB receptors in cancer: clinical implications. [PDF]
Oncotarget, 2017 The ERBB family of receptor tyrosine kinases has been implicated in carcinogenesis for over three decades with rigorous attention to EGFR and HER2. ERBB receptors, consisting of EGFR, HER2, HER3, and HER4 are part of a complicated signaling network that ...
Mishra R, Hanker AB, Garrett JT.
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The spatiotemporal organization of ErbB receptors: insights from microscopy. [PDF]
Cold Spring Harb Perspect Biol, 2014 Signal transduction is regulated by protein-protein interactions. In the case of the ErbB family of receptor tyrosine kinases (RTKs), the precise nature of these interactions remains a topic of debate. In this review, we describe state-of-the-art imaging
Valley CC, Lidke KA, Lidke DS.
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Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo [PDF]
Journal of Translational Medicine, 2022 Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM.
Roberto Bei +17 more
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Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors. [PDF]
BMC Cancer, 2015 Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constitutively activated variants of IGF-IR and EGFR ...
Urtasun N +3 more
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Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. [PDF]
PLoS ONE, 2012 First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies.
Ronald J Hause +5 more
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ErbB receptors and their growth factor ligands in pediatric intestinal inflammation. [PDF]
Pediatr Res, 2014 The ErbB tyrosine kinases (epidermal growth factor receptor (EGFR), ErbB2/HER2, ErbB3, and ErbB4) are cell surface growth factor receptors widely expressed in many developing mammalian tissues, including in the intestinal tract.
Frey MR, Brent Polk D.
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