Synergistic Strategies in Systemic Therapy for Advanced Hepatocellular Carcinoma
Global Challenges, Volume 10, Issue 1, January 2026.This article comprehensively examines the evolving landscape of systemic therapy for advanced hepatocellular carcinoma. It covers the progress in tyrosine kinase inhibitors and immune checkpoint inhibitors, analyzes the efficacy of novel combination strategies, and discusses current challenges like drug resistance and the lack of biomarkers.
Yongxin Yu +5 more
wiley +1 more source
Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses
Molecular Systems Biology, 2007 Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes ...
Marc R Birtwistle +5 more
doaj +1 more source
BMC Cancer, 2010 Background Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated with suppression in ErbB receptor ...
Sylvester Paul W +2 more
doaj +1 more source
ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury [PDF]
, 2019 Katalin Bartus +5 more
openalex +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.ABSTRACT Aims Guideline‐directed medical therapy (GDMT) implementation in heart failure with reduced ejection fraction (HFrEF) remains suboptimal. A computable algorithm was developed to generate a medication optimization score (MOS) and provide guideline‐based recommendations.
Mohamed S. Ali +5 more
wiley +1 more source
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. [PDF]
Cancers (Basel), 2022 Adediran S +9 more
europepmc +1 more source
ERBB Receptor Regulation of ESX/ELF3 Promotes Invasion in Breast Epithelial Cells [PDF]
, 2010 Jean Philippe Coppé +8 more
openalex +1 more source
Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in Mice
Aging Cell, Volume 25, Issue 1, January 2026.Graded calorie restriction in male mice modified epigenetic signatures of the liver and slowed ageing rate in a graded manner. ABSTRACT DNA methylation variation is associated with chronological ageing. Calorie restriction (CR) prolongs lifespan and healthspan in many species.
Timothy P. Moulds +6 more
wiley +1 more source
Primary chemotherapy in breast invasive carcinoma: predictive value of the immunohistochemical detection of hormonal receptors, p53, c-erbB-2, MiB1, pS2 and GST pi [PDF]
, 1996 Gaëtan MacGrogan +6 more
openalex +1 more source
Increased activation of ErbB and NFκB signalling pathways in Darier disease affected skin
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Nancy Ernst +2 more
wiley +1 more source