Results 101 to 110 of about 38,315 (266)
Cancer Science, EarlyView.Oral squamous cell carcinoma (OSCC), the most common type of oral cancer, has a poor prognosis. This study found high Ephrin type‐B receptor 4 (EPHB4) expression, mainly localized on the tumor cell membrane, in most OSCC cases, suggesting EPHB4 as a promising target for chimeric antigen receptor (CAR) T cell therapy.
Yusuke Ito +10 more
wiley +1 more source
Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death
Cancer Science, EarlyView.()‐D‐Tox peptide binding to the ligands triggers their internalization via clathrin‐mediated endocytosis. Intracellular presence of ()‐D‐Tox peptide induces a transient loss of mitochondrial membrane integrity and oligomerization of MLKL. Translocation of the oligomers to the plasma membrane causes a leakage of the cytosolic content and ultimately ...
Maria F. Setiawan +2 more
wiley +1 more source
Folia Histochemica et Cytobiologica, 2010 The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz +2 more
doaj +1 more source
Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors
Cell Reports Medicine, 2021 Summary: Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid tumors has proven challenging, in large part because of the lack of tumor-specific targets to direct CAR binding. Tumor selectivity is crucial because on-
Paris Kosti +14 more
doaj
Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury
The Journal of Physiology, EarlyView.Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen +6 more
wiley +1 more source
Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv
Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]
Front Oncol, 2023 Breitenecker K +10 more
europepmc +1 more source
Cancer Innovation, Volume 4, Issue 3, June 2025.ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer +3 more
wiley +1 more source
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author. [PDF]
J Mammary Gland Biol Neoplasia, 2023 Morato A, Accornero P, Hovey RC.
europepmc +1 more source
Fexofenadine Overcomes Osimertinib Resistance by Inhibiting c‐Met in Non‐Small Cell Lung Cancer
MedComm – Oncology, Volume 4, Issue 2, June 2025.Fexofenadine was identified as a new Met inhibitory drug by a computational drug repurposing tool called “DRAR‐CPI” via chemical‐protein interactome analysis of known Met inhibitors. It was shown to overcome osimertinib resistance in non‐small cell lung cancer by inhibiting Met in vitro and in vivo.
Kenneth K. W. To +2 more
wiley +1 more source