Results 101 to 110 of about 33,653 (199)

Active Macropinocytosis, Lipid Catabolism, and Exhausting Immune Microenvironment of Ascites Tumor Cells Are Involved in Resistance to Platinum‐Based Therapy in Patients With High‐Grade Serous Ovarian Cancer

open access: yesMedComm, Volume 7, Issue 3, March 2026.
Platinum‐resistant patients exhibited ascites suffer from immune exhaustion and enriched in lipids, which is used by tumor cells as energy resources to counteract platinum damage through active macropinocytosis and lipid catabolism. These resistant features in ascites can also predict, to a certain extent, the efficacy of platinum‐based therapy in ...
Ruiqi Zheng   +12 more
wiley   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

open access: yesMedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman   +7 more
wiley   +1 more source

Uterine Serous Carcinoma Arising From Endometrial Polyp: A Case Report

open access: yesGynecology Obstetrics & Reproductive Medicine, 2009
Serous carcinoma is the prototype of type II endometrial carcinoma. A 71-year-old woman who had history of smoking, diabetes mellitus and hypertension admitted to the hospital with postmenopausal uterine bleeding.
Sibel Bektaş   +4 more
doaj  

Amivantamab Monotherapy for Lung Adenocarcinoma With Leptomeningeal Seeding: A Case Report

open access: yesRespirology Case Reports, Volume 14, Issue 3, March 2026.
We report a case of a patient with NSCLC who developed leptomeningeal seeding (LMS) after failure of first‐line therapy and showed a marked clinical and radiologic response to amivantamab monotherapy. ABSTRACT Non–small cell lung cancer (NSCLC) is characterised by a number of driver mutations, among which epidermal growth factor receptor (EGFR) exon 20
Kyeoungseo Park   +2 more
wiley   +1 more source

Analysis of Human miRNA Derived From Bladder Epithelial Cells Infected With Uropathogenic Escherichia coli

open access: yesAPMIS, Volume 134, Issue 3, March 2026.
ABSTRACT MicroRNAs (miRNAs) have been shown to regulate many cellular processes and to play a role in host‐pathogen interactions. However, the role of miRNA in urinary tract infection (UTI) remains unclear. The aim of this study was to analyze and compare miRNAs from supernatants of human bladder epithelial cells infected with ESBL‐producing (ESBL019 ...
Katarina Persson   +3 more
wiley   +1 more source

Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia

open access: yesJournal of Pain Research, 2013
Satoshi Mizobuchi,1* Hirotaka Kanzaki,1–3* Hiroki Omiya,1 Yoshikazu Matsuoka,1 Norihiko Obata,1 Ryuji Kaku,1 Hirochika Nakajima,1 Mamoru Ouchida,2 Kiyoshi Morita11Department of Anesthesiology and Resuscitology, 2Department of Molecular Genetics,
Mizobuchi S   +8 more
doaj  

Altered peripheral CRY1 gene expression may contribute to both organic and functional gastrointestinal disease

open access: yesExperimental Physiology, Volume 111, Issue 3, Page 946-962, 1 March 2026.
ABSTRACT Gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are characterized by alterations in physiological and immune functions. Given the circadian clock influences gastrointestinal physiology and immunity, we hypothesized that the peripheral circadian clock is altered in these patients and ...
Sophie Fowler   +12 more
wiley   +1 more source

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