Results 101 to 110 of about 60,784 (262)

Afatinib efficacy against squamous cell carcinoma of the head and neck cell lines in vitro and in vivo. [PDF]

, 2015
Epidermal growth factor receptor (EGFR) inhibitors have demonstrated efficacy in squamous cell carcinoma of the head and neck (SCCHN). In addition to EGFR, other ErbB family members are expressed and activated in SCCHN. Afatinib is an ErbB family blocker
Baum, Anke, Cohen, Ezra EW, Grushko, Tatyana A, Hardeman, Ashley, Liu, Jing, Olopade, Olufunmilayo I, Solca, Flavio, Soneru, Christian, Young, Natalie R   +8 more
core   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]

, 2014
Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core   +1 more source

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB‐inhibitor‐induced phenotypes

The FEBS Journal, EarlyView.
Whole‐organism phosphoproteomics after ErbB inhibitor treatment was assessed in zebrafish embryos. Differential signaling was uncovered after treatments with more selective ErbB inhibitors and pan‐ErbB inhibitors, despite similar neurological and myocardial phenotypes.
Katri Vaparanta, Zejia Song, Iman Farahani, Anne Jokilammi, Johannes Merilahti, Johanna Örling, Noora Virtanen, Pekka Haapaniemi, Cecilia Sahlgren, Klaus Elenius, Ilkka Paatero   +10 more
wiley   +1 more source

RANKL Signaling and ErbB Receptors in Breast Carcinogenesis

Trends in Molecular Medicine, 2016
ErbB family members, ErbB1/EGFR/HER-1, ErbB2/HER-2, ErbB3/HER-3 and ErbB4/HER-4, have been implicated in breast cancer (BC) tumorigenicity. Recently, crucial roles for RANK/RANKL signaling in addition to key downstream factor NF-κB have been demonstrated in mammary tumorigenesis.
Zoi, I., Karamouzis, M.V., Adamopoulos, C., Papavassiliou, A.G.   +3 more
openaire   +3 more sources

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice [PDF]

, 2014
A present challenge in breast oncology research is to identify therapeutical targets which could impact tumor progression. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 20% of breast cancers, and NTSR1 overexpression was ...
Cayre, Anne, De Wever, Olivier, Doan, Van Kien, Dupouy, Sandra, Forgez, Patricia, Gompel, Anne, Kouchkar, Amal, Liu, Jin, Mourra, Najat, Penault Llorca, Frédérique, Wu, Zherui   +10 more
core   +3 more sources

Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin

Drug Design, Development and Therapy, 2018
Dehua Liao,1,2 Yujin Guo,3 Daxiong Xiang,2 Ruili Dang,3 Pengfei Xu,3 Hualin Cai,2 Lizhi Cao,1 Pei Jiang3 1Department of Pharmacy, Hunan Cancer Hospital, 2Department of Pharmacy, Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital,
Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P   +7 more
doaj  

Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib

Experimental Hematology & Oncology, 2018
Background Lapatinib is a tyrosine kinase inhibitor that blocks the HER2 receptor and is typically used in the setting of metastatic breast cancer. Both ERBB2 (HER2) and ERBB3 (HER3) belong to the same family of receptor tyrosine kinases. Dimerization of
John D. Strickley, Aaron C. Spalding, M. Tye Haeberle, Timothy Brown, Don A. Stevens, Jae Jung   +5 more
doaj   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo [PDF]

, 2015
Violacein (VIO; 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one), an indole-derived purple-colored pigment, produced by a limited number of Gram-negative bacteria species, including Chromobacterium ...
Bei, Roberto, Benvenuto, Monica, DI STEFANO, Enrica, Fantini, Massimo, LA REGINA, Giuseppe, Manzari, Vittorio, Masuelli, Laura, Mattei, Maurizio, Mattera, Rosanna, Modesti, Andrea, Pantanella, Fabrizio, Schippa, Serena, Silvestri, Romano   +12 more
core   +1 more source