Prediction of Binding Affinity for ErbB Inhibitors Using Deep Neural Network Model with Morgan Fingerprints as Features [PDF]
arXivThe ErbB receptor family, including EGFR and HER2, plays a crucial role in cell growth and survival and is associated with the progression of various cancers such as breast and lung cancer. In this study, we developed a deep learning model to predict the binding affinity of ErbB inhibitors using molecular fingerprints derived from SMILES ...
arxiv
Accuracy of direct gradient sensing by cell-surface receptors [PDF]
arXiv, 2009 Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion.
arxiv
Spatiotemporal Control Over Circadian Rhythms With Light
Medicinal Research Reviews, Volume 45, Issue 3, Page 968-984, May 2025.ABSTRACT Circadian rhythms are endogenous biological oscillators that synchronize internal physiological processes and behaviors with external environmental changes, sustaining homeostasis and health. Disruption of circadian rhythms leads to numerous diseases, including cardiovascular and metabolic diseases, cancer, diabetes, and neurological disorders.
Dušan Kolarski +2 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2001 There are few data evaluating biological markers for men with breast cancer. The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival ...
M. Mourão Netto +4 more
doaj +1 more source
Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization. [PDF]
Mol Biol Res Commun, 2023 Mashayekh-Poul R +2 more
europepmc +1 more source
DETECTION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND C-ERBB-2 GENE AMPLIFICATION IN TRANSITIONAL-CELL BLADDER-CARCINOMA USING THE DIFFERENTIAL PCR TECHNIQUE [PDF]
, 1994 Vassilis G. Gorgoulis +3 more
openalex +1 more source
International Journal of Dermatology, Volume 64, Issue 5, Page 870-881, May 2025.Drug target prediction algorithms based on proteogenomic profiling. Abstract Background The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune‐checkpoint‐based therapies still poses a significant problem.
Indira Pla +35 more
wiley +1 more source
The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease
Biomarker Insights, 2015 Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj +1 more source
Chemical sensing by cell-surface chemoreceptor arrays: the roles of receptor cooperativity and adaptation [PDF]
arXiv, 2012 Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing.
arxiv
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. [PDF]
Cancers (Basel), 2022 Adediran S +9 more
europepmc +1 more source